Publications 2025
Amoah BY, Yao Bayamina S, Gborsong C, Owusu H, Asare GA, Yeboah EK, Ablakwa J, Hammond G. Modifiable life style factors and male reproductive health: a cross-sectional study in IVF clinic attendees in Ghana. Front Reprod Health 2025
Annamalai K, Dilliker S, Buchholz E, Castro-Hernandez R, Panyam N, Pommeranz A, Wiederhake P, Wery von Limont N, Hempel N, Ebner V, Swarnkar S, Mohamed BA, Streckfuss-Bomeke K, Steffens S, Herzig S, Ebert A, Fischer A, Toischer K. Deregulation of m6A-RNA methylation impairs adaptive hypertrophic response and drives maladaptation via mTORC1-S6K1-hyperactivation and autophagy impairment. Cell Commun Signal 2025
Andreoti TA, Maiolo M, Tuleja A, Döring Y, Schaller A, Vassella E, Boon LM, Baumgartner I, Bernhard SM, Zweier C, Vikkula M, Rössler J. Non-Hotspot PIK3CA Variants Have Higher Variant Allele Frequency and are More Common in Syndromic Vascular Malformations. Am J Med Genet A. 2025
Asare Y, Yan G, Schlegl C, Prestel M, van der Vorst EPC, Teunissen AJP, Aronova A, Tosato F, Naser N, Caputo J, Prevot G, Azzun A, Wefers B, Wurst W, Schneider M, Forne I, Bidzhekov K, Naumann R, van der Laan SW, Brandhofer M, Cao J, Roth S, Malik R, Tiedt S, Mulder WJM, Imhof A, Liesz A, Weber C, Bernhagen J, Dichgans M. A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis. Immunity 2025
Azarshin SZ, Marashi M, Abedi Kichi Z, Boroumand MA, Behmanesh M. Hyperglycemia Increased The Expression of CALCRL G Protein-Coupled Receptor in Monocytes from Diabetic Patients. Cell J 2025
Ben-Aicha S, van der Vorst EPC. Shaping the future of cardiovascular research: a focus on cardioimmunology. Eur Heart J 2025
Bonfiglio CA, Lacy M, Triantafyllidou V, Farina FM, Janjic A, Nitz K, Wu Y, Bazioti V, Avcilar-Kucukgoze I, Marques YFS, Joppich M, Kumkum M, Röß K, Venkatasubramani AV, Imhof A, Enard W, Maegdefessel L, de Winther M, Weber C, Santovito D, Lutgens E, Atzler D. Ezh2 Shapes T Cell Plasticity to Drive Atherosclerosis. Circulation 2025
Bonneuil WV, Watson DJ, Mohanta SK, Habenicht AJR, Moore JE, Jr., Frattolin J. Atherosclerosis increases adventitial pressure and limits solute transport via fluid-balance mechanisms. Biomech Model Mechanobiol 2025
Bonnin-Marquez A, Jankowski J, Maas SL, Hermann J, Kahles F, Lellig M, Fliser D, Schunk S, Stamellou E, Berger M, Speer T, Kalim S, Leong Wong DW, van der Vorst EPC, Jankowski V. Guanidinylation compromises the anti-inflammatory and anti-oxidative properties of apolipoprotein A-I in chronic kidney disease progression. Kidney Int 2025
Bonnin-Marquez A, Maas SL, Corcini-Berndt M, Van der Vorst EPC. Unbiased kinome profiling identifies key and novel mediators of chronic kidney disease in hyperlipidemic mice. Front Physiol 2025
Brunetta HS, Mori MA, Bartelt A. Oxidative Phosphorylation in Uncoupled Mitochondria. Bioessays 2025
Chen Z, Li S, Song X, Diagel A, Li L, Moggio A, Li Z, Chen Y, Dang T, Li M, Shen R, Ma A, Schwab M, Barbera N, Lehertshuber C, Romer A, Brizzi LF, Krefting J, Krüger N, Sager H, Boon R, Civelek M, Romanoski C, Lusis A, Kessler T, Maegdefessel L, Schober A, von Scheidt M, Björkegren J, Nazari-Jahantigh M, Schunkert H. An interplay of non-coding RNAs regulates CDH13 expression and affects endothelial function and coronary artery disease risk. Res Sq [Preprint]. Res Sq 2025
Chong-Nguyen C, Yilmaz B, Coles B, Sokol H, MacPherson A, Siepe M, Reineke D, Mosbahi S, Tomii D, Nakase M, Atighetchi S, Ferro C, Wingert C, Grani C, Pilgrim T, Windecker S, Blasco H, Dupuy C, Emond P, Banz Y, Losmanova T, Doring Y, Siontis GCM. A scoping review evaluating the current state of gut microbiota and its metabolites in valvular heart disease physiopathology. Eur J Clin Invest 2025
Davidson SM, Andreadou I, Antoniades C, Bartunek J, Basso C, Brundel B, Byrne RA, Chiva-Blanch G, da Costa Martins P, Evans PC, Girao H, Giricz Z, Gollmann-Tepekoylu C, Guzik T, Gyongyosi M, Hubner N, Joner M, Kleinbongard P, Krieg T, Liehn E, Madonna R, Maguy A, Paillard M, Pesce M, Petersen SE, Schiattarella GG, Sluijter JPG, Steffens S, Streckfuss-Bomeke K, Thielmann M, Tucker A, Van Linthout S, Wijns W, Wojta J, Wu JC, Perrino C. Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC. Cardiovasc Res 2025
de la Puente-Secades S, Mikolajetz D, Gayrard N, Hermann J, Jankowski V, Bhargava S, Meyer A, Argiles A, Saritas T, van der Vorst EPC, Wu Z, Noels H, Tepel M, Alghamdi K, Ward D, Zidek W, Wolf M, Floege J, Schurgers L, Orth-Alampour S, Jankowski J. Vasoconstriction-inhibiting factor: an endogenous inhibitor of vascular calcification as a calcimimetic of calcium-sensing receptor. Cardiovasc Res 2025
El Bounkari O, Zan C, Yang B, Ebert S, Wagner J, Bugar E, Kramer N, Bourilhon P, Kontos C, Zarwel M, Sinitski D, Milic J, Jansen Y, Kempf WE, Sachs N, Maegdefessel L, Ji H, Gokce O, Riols F, Haid M, Gerra S, Hoffmann A, Brandhofer M, Avdic M, Bucala R, Megens RTA, Willemsen N, Messerer D, Schulz C, Bartelt A, Harm T, Rath D, Doring Y, Gawaz M, Weber C, Kapurniotu A, Bernhagen J. An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis. Nat Commun 2025
Ghiasvand T, Karimi J, Khodadadi I, Yazdi A, Khazaei S, Kichi ZA, Hosseini SK. The interplay of LDLR, PCSK9, and lncRNA- LASER genes expression in coronary artery disease: implications for therapeutic interventions. Prostaglandins Other Lipid Mediat 2025
Gottschlich A, Grünmeier R, Hoffmann GV, Nandi S, Kavaka V, Müller PJ, Jobst J, Öner A, Kaiser R, Gärtig J, Piseddu I, Frenz-Wiessner S, Fairley SD, Schulz H, Igl V, Janert TA, di Fina L, Mulkers M, Thomas M, Briukhovetska D, Simnica D, Carlini E, Tsiverioti CA, Trefny MP, Lorenzini T, Märkl F, Mesquita P, Brabenec R, Strzalkowski T, Stock S, Michaelides S, Hellmuth J, Thelen M, Reinke S, Klapper W, Gelebart PF, Nicolai L, Marr C, Beltrán E, Megens RTA, Klein C, Baran-Marszak F, Rosenwald A, von Bergwelt-Baildon M, Bröckelmann PJ, Endres S, Kobold S. Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma. Blood 2025
Gutjahr JC, Hub E, Anderson CA, Samus M, Artinger K, Gomez EA, Ratswohl C, Wickli N, Raum M, Dufton N, Dalli J, Burden JJ, Duchene J, Rot A. Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and enucleation. Sci Signal 2025
Gultom M, Lin L, Brandt CB, Milusev A, Despont A, Shaw J, Doring Y, Luo Y, Rieben R. Sustained Vascular Inflammatory Effects of SARS-CoV-2 Spike Protein on Human Endothelial Cells. Inflammation 2025
Hristov M, Weber C. Monocyte Subsets in Cardiovascular Disease: A Biomarker Perspective. Thromb Haemost 2025
Huchzermeier R, van der Vorst EPC. Aryl hydrocarbon receptor (AHR) and nuclear factor erythroid-derived 2-like 2 (NRF2): An important crosstalk in the gut-liver axis. Biochem Pharmacol 2025
Jin H, Maas SL, Zou Y, Lu C, Yu B, Huchzermeier R, Nadeau S, Dos Santos J, Gijbels M, Mees BME, Smirnov E, Matic L, Hedin U, Maffia P, Monaco C, Sluimer JC, Martins GA, van der Vorst EPC, Biessen EAL. Identification of a PRDM1-regulated T cell network to regulate atherosclerotic plaque inflammation. Genome Med 2025
Katoozian F, Abedi Kichi Z, Sharifi R, Shirvani-Farsani Z. The Expression Analysis of Long Non-coding RNAs Related to Wnt/beta-Catenin Signaling in Pancreatic Cancer Patients. Biochem Genet 2025
Kirmes K, Han J, Klug M, Bloxham CJ, Babyak O, Bernett J, Arend L, Manz Q, Raka L, Schwartz L, Hoffmann M, Rosenbaum M, Ruland J, Ciora OA, Louadi Z, Tsoy O, Newaz K, Modica J, Dioguardi CC, Peano C, Muller M, Santovito D, Viggiani G, Kuhne S, von Scheidt M, Nicolai L, Wu T, Baumbach J, Chiarito M, Laugwitz KL, Condorelli G, Raake PWJ, List M, Bernlochner I, Bongiovanni D. Reticulated platelets in coronary artery disease: a multidimensional approach unveils prothrombotic signalling and novel therapeutic targets. Eur Heart J 2025
Koker SC, Tsokanos FF, El-Merahbi R, Jha AK, Cicatelli K, Weber P, Mhamane A, Kaltenecker D, Morigny P, Loft A, Klepac K, Maida A, Molocea CE, Hass D, Vogl ES, Alfaro AJ, Sun W, Zitzelsberger H, Unger K, Szendrodi J, Li Y, Diaz MB, Wolfrum C, Bartelt A, Herzig S, Georgiadi A. The TBLR1/TBL1 Co-Factor Complex Acts as a Transcriptional Checkpoint in the Brown Adipose Tissue Response to Prolonged Cold Exposure. FASEB J 2025
Lauxen JS, Vondenhoff S, Junho CVC, Martin P, Fleig S, Schutt K, Schulze-Spate U, Soehnlein O, Prates-Roma L, Doring Y, Baaten C, Noels H. Neutrophil Function in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Acta Physiol (Oxf) 2025
Lip GYH, Rigby A, Weber C. Welcoming 2025—A Year of Collaboration and Progress. Thromb Haemost 2025
Martini E, Cremonesi M, Felicetta A, Serio S, Puccio S, Pelamatti E, van Beek JJP, Papadopoulou V, Catalano C, Fanuele F, Giuliano D, Basso G, Bonfiglio CA, Panico C, Vacchiano M, Carullo P, Papa L, D'Andrea C, Tuzger N, Marchini S, Magistroni P, Deaglio S, Amoroso A, Lugli E, Condorelli G, Kallikourdis M. Autoimmune-Like Mechanism in Heart Failure Enables Preventive Vaccine Therapy. Circ Res 2025
Matta L, Weber P, Erener S, Walth-Hummel A, Hass D, Buhler LK, Klepac K, Szendroedi J, Guerra J, Rohm M, Sterr M, Lickert H, Bartelt A, Herzig S. Chronic intermittent fasting impairs beta cell maturation and function in adolescent mice. Cell Rep 2025
Möller-Ramon Z, Aslani M, Sobczak N, Hristov M, Weber C, Rot A, Duchêne J. The 129 strain-derived passenger mutations in ACKR1-deficient mice alter the expression of PYHIN and Fc-gamma receptor genes. Journal of Leukocyte Biology 2025
Markwirth P, Selejan SR, Hohl M, Schunk SJ, Muller A, Wagenpfeil S, Wagmann L, Kahles F, Tokcan M, Therre M, van der Vorst EPC, Rau M, Noels H, Wollenhaupt J, Mahfoud F, Bohm M. Renal Denervation Improves Uremic Cardiomyopathy in Rats With Chronic Kidney Disease. J Am Heart Assoc 2025
Metz F, Beilmann J, Bats SH, Latoscha A, Witte G, Megens RTA, Hopfner KP, Thorell K, Fischer W, Terradot L, Suerbaum S, Josenhans C. Functional and intricate interaction network connecting Helicobacter pylori Cag type 4 secretion system surface proteins with outer membrane proteins HopQ and HopZ. Microlife 2025
Mohanta SK, Heron C, Klaus-Bergmann A, Horstmann H, Brakenhielm E, Giannarelli C, Habenicht AJR, Gerhardt H, Weber C. Metabolic and Immune Crosstalk in Cardiovascular Disease. Circulation Research 2025
Nageswaran V, Carreras A, Reinshagen L, Beck KR, Steinfeldt J, Henricsson M, Ramezani Rad P, Peters L, Strassler ET, Lim J, Verhaar B, Doring Y, Weber C, Konig M, Steinhagen-Thiessen E, Demuth I, Krankel N, Leistner DM, Potente M, Nieuwdorp M, Knaus P, Kuebler WM, Ferrell M, Nemet I, Hazen SL, Landmesser U, Backhed F, Haghikia A. Gut Microbial Metabolite Imidazole Propionate Impairs Endothelial Cell Function and Promotes the Development of Atherosclerosis. Arterioscler Thromb Vasc Biol 2025
Nahrendorf M, Kumowski N, Steffens S. Neutrophils in Myocardial Infarction. JACC Basic Transl Sci. 2025
Noels H, van der Vorst EPC, Rubin S, Emmett A, Marx N, Tomaszewski M, Jankowski J. Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure. Circ Res 2025
Ofoghi A, Kotschi S, Lemmer IL, Haas DT, Willemsen N, Bayer B, Jung AS, Moller S, Haberecht-Muller S, Kruger E, Krahmer N, Bartelt A. Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis. Cell Death Differ 2025
Pannhausen J, Chughtai AA, Yuce CL, Melzer MK, Ma Y, Seillier L, van der Vorst EPC, Andrieux G, Wirtz J, Leypold S, Kuhnel MP, Hoffmann P, Heilmann-Heimbach S, Boerries M, Kleger A, Saar M, Eble MJ, Jonigk DD, Gaisa NT, Rose M. Targeting ATR offers multifaceted treatment strategies involving RAD51-mediated compensatory DNA repair in bladder cancer. J Exp Clin Cancer Res 2025
Parma L, Sachs N, Sobczak N, Li Z, Merchant K, Pauli J, Depuydt MAC, Wezel A, Smeets HJ, Bot I, Slütter B, Maegdefessel L, Weber C, Duchêne J, Megens RTA. CXCL12 Derived From ACKR1+ Intraplaque Neovessels Mediates CD8 + T Cell Recruitment in Human Atherosclerosis. Circulation 2025
Peters L, Rakateli L, Huchzermeier R, Bonnin-Marquez A, Maas SL, Lin C, Jans A, Geng Y, Gorter A, Gijbels M, Rensen S, Olinga P, Hendrikx T, Krawczyk M, Brisbois M, Jankowski J, Bidzhekov K, Weber C, Biessen EAL, Shiri-Sverdlov R, Houben T, Doering Y, Bartneck M, van der Vorst E. MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles. Elife 2025
Peters LJF, Bidzhekov K, Bonnin-Marquez A, Sundararaman SS, Huchzermeier R, Maas SL, Abschlag K, Jans A, Lin C, Haberbosch M, Jansen Y, Yu B, Sluimer JC, Gijbels MJ, Jankowski J, Bartneck M, Biessen EAL, Weber C, Döring Y, van der Vorst EPC. MicroRNA-26b-/- augments atherosclerosis, while mimic-loaded nanoparticles reduce atherogenesis. Cardiovasc Res. 2025
Pfeferman MB, Rashedi S, Lip GYH, Weber C, O'Donoghue ML, Nissen S, Nicholls SJ, Natarajan P, Plutzky J, Libby P, Goldhaber SZ, Piazza G, Bikdeli B. Lipoprotein(a) and Venous Thromboembolism: Association, Causality, and Medications. Thromb Haemost 2025
Ran Y, Li L, Wang Z, Sun T, Wen C, Zhang Y, Wang S, Jiang S, Zheng J, Yin C, Zhang C. Regulator of G-protein signaling 14 (RGS14) promotes cancer growth in hepatocellular carcinoma. Cancer Genet 2025
Ran Y, Zhu J, Sun T, Zhang Y, Zhang C, Li Y, Li Z, Wang S, Li L, Zheng J, Yin C, Habenicht AJR, Wang Z. Single cell RNA sequencing reveals a dysbalance of proinflammatory vs. immunosuppressive dendritic cells in mouse and human aortic aneurysms. Front Cardiovasc Med 2025
Rigby A, Albisetti M, Favaloro EJ, Koenen RR, Langer F, Lip GYH, Ruhl H, Weber C. Reflections on World Thrombosis Day 2024. Thromb Haemost 2025
Rojhannezhad M, Abedi Kichi Z, Nikravesh A, Behmanesh M. GAS5 Long Noncoding RNA Regulates CD20 Expression and Rituximab Response. Adv Pharm Bull 2025
Scherrer P, Marchini T, Li X, Al Hadi El Rabih A, Pennig J, Sol Mitre L, Dominguez J, Gissler MC, Pisani G, Anto Michel N, Mwinyella T, Abogunloko T, Hoppe N, Spiga L, Stallmann D, Horstmann H, Siegel PM, Hansen S, Hilgendorf I, Lutgens E, Weber C, Gerdes N, Zirlik A, Westermann D, Willecke D, Wolf D. Endothelial CD40L serves as a pro-atherogenic adhesion receptor in the inflamed vasculature, Atherosclerosis, 2025
Schopohl B, Kohlhaas M, Nickel AG, Schiuma AF, Maas SL, van der Vorst EPC, Shia YX, Maack C, Steffens S, Puhl SL. Gpr55 deficiency crucially alters cardiomyocyte homeostasis and counteracts angiotensin II induced maladaption in female mice. Br J Pharmacol 2025
Shia YX, Pappritz K, Kaltenbach AC, Li G, Fardella V, Van Linthout S, Carnevale D, Steffens S, Puhl SL. Pericardial adipose tissue promotes transition to heart failure with reduced ejection fraction upon pressure-overload in mice. Basic Res Cardiol 2025
Soehnlein O, Lutgens E, Doring Y. Distinct inflammatory pathways shape atherosclerosis in different vascular beds. Eur Heart J 2025
Strohm L, Ubbens H, Mihalikova D, Czarnowski A, Stamm P, Molitor M, Finger S, Oelze M, Atzler D, Wenzel P, Lurz P, Munzel T, Weber C, Lutgens E, Daiber A, Daub S. CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension. Redox Biol 2025
Tuleja A, Doring Y, Helfenstein FN, Andreoti TA, Rossler J, Boon LM, Vikkula M, Haupt F, Hamvas G, Bernhard SM, Baumgartner I. Alcohol embolization versus non-invasive treatment for pain relief in peripheral venous malformations: a comparative study. Cardiovasc Diagn Ther 2025
van der Vorst EPC, Kroon J, Guillamat-Prats R, Doring Y. Editorial: Vascular- and immuno-metabolism as drivers of cardiovascular disease: insights obtained from omics approaches. Front Cell Dev Biol 2025
van der Vorst EPC, Lembo G. Harnessing the power of the brain to fight metabolic diseases. Cardiovasc Res 2025
Weber C, Rigby A, Lip GYH. Thrombosis and Haemostasis 2024 Editors' Choice Papers. Thromb Haemost 2025
Wrobel J, Jung S, Kiessling P, Scheidereit E, Kuppe C, Bazioti V, Atzler D, Winkels H. High-Resolution Spatial Profiling Unveils Cellular Heterogeneity in Murine Atherosclerosis. Thromb Haemost 2025
Yerly A, van der Vorst EPC, Schindewolf M, Kotelis D, Noels H, Doring Y. Chemokine-receptor-guided B-cell immunity in cardiovascular disease. Basic Res Cardiol 2025