Publications 2022
Asare Y, Shnipova M, Zivkovic L, Schlegl C, Tosato F, Aronova A, Brandhofer M, Strohm L, Beaufort N, Malik R, Weber C, Bernhagen J, Dichgans M (2022). IKKbeta binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses. Signal Transduct Target Ther. 7:355. PMID 36257930. [A1, A3, A10, B3]
Bosmans LA, van Tiel CM, Aarts S, Willemsen L, Baardman J, van Os BW, den Toom M, Beckers L, Ahern DJ, Levels JHM, Jongejan A, Moerland PD, Verberk SGS, van den Bossche J, de Winther M, Weber C, Atzler D, Monaco C, Gerdes N, Shami A, Lutgens E (2022). Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state. Cardiovasc Res. PMID 35587037. [A1, A5, A10]
Bozoglu T, Lee S, Ziegler T, Jurisch V, Maas S, Baehr A, Hinkel R, Hoenig A, Hariharan A, Kim CI, Decker S, Sami H, Koppara T, Oellinger R, Muller OJ, Frank D, Megens RTA, Nelson P, Weber C, Schnieke A, Sperandio M, Santamaria G, Rad R, Moretti A, Laugwitz KL, Soehnlein O, Ogris M, Kupatt C (2022). Endothelial retargeting of AAV9 in vivo. Adv Sci (Weinh). e2103867. PMID 35023328. [A1, A6, A10, B5, C3, Z1]
Brandhofer M, Hoffmann A, Blanchet X, Siminkovitch E, Rohlfing AK, El Bounkari O, Nestele JA, Bild A, Kontos C, Hille K, Rohde V, Frohlich A, Golemi J, Gokce O, Krammer C, Scheiermann P, Tsilimparis N, Sachs N, Kempf WE, Maegdefessel L, Otabil MK, Megens RTA, Ippel H, Koenen RR, Luo J, Engelmann B, Mayo KH, Gawaz M, Kapurniotu A, Weber C, von Hundelshausen P, Bernhagen J. (2022). Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Cell Mol Life Sci. 79:512. PMID 36094626. [A1, A2, A3, A10, B5, Z1]
Daugherty A, Hegele RA, Lu HS, Mackman N, Rader DJ, Weber C (2022). Web of science's citation median metrics overcome the major constraints of the journal impact factor. Arterioscler Thromb Vasc Biol. ATVBAHA122317426. PMID 35109675. [A1, A10]
Egea V, Megens RTA, Santovito D, Wantha S, Brandl R, Siess W, Khani S, Soehnlein O, Bartelt A, Weber C, Ries C (2022). Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques. Cardiovasc Res. PMID 35238350. [A1, A6, A10, B5, B10, Z01]
Evans BR, Yerly A, van der Vorst EPC, Baumgartner I, Bernhard SM, Schindewolf M, Döring Y (2022). Inflammatory mediators in atherosclerotic vascular remodeling. Front Cardiovasc Med. 9:868934. PMID 35600479. [A1]
Evans PC, Davidson SM, Wojta J, Bäck M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP, Morawietz H, Osto E, Padró T, Sluimer JC, Tocchetti CG, Van der Heiden K, Vilahur G, Waltenberger J, Weber C (2022). From novel discovery tools and biomarkers to precision medicine - basic cardiovascular science highlights of 2021/2022. Cardiovasc Res. PMID 35899362. [A1, A10]
Farina FM, Santovito D, Weber C (2022). Two-faced janus: CCR2-expressing macrophages and their dual role in allograft rejection of the transplanted heart. Circulation. 146:639-642. PMID 35994560. [A1, A10, B5]
Faussner A, Deininger MM, Weber C, Steffens S (2022). Direct addition of poly-lysine or poly-ethylenimine to the medium: A simple alternative to plate pre-coating. PLoS One. 17:e0260173. PMID 35994560. [A1, A10, B9]
Ferdinandy P, Koller A, Weber C, Wojta J, Waltenberger J (2022). Frontiers of CardioVascular Biomedicine 2022 Budapest is on in person! The excellent program proves that scientists won against Covid-19. Cardiovasc Res. PMID 35438746. [A1, A10]
Friess MC, Kritikos I, Schineis P, Medina-Sanchez JD, Gkountidi AO, Vallone A, Sigmund EC, Schwitter C, Vranova M, Matti C, Arasa J, Saygili Demir C, Bovay E, Proulx ST, Tomura M, Rot A, Legler DF, Petrova TV, Halin C (2022). Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. Cell Rep. 38:110334. PMID 35108538.
Ganesh N, van der Vorst EPC, Spiesshofer J, He S, Burgmaier M, Findeisen H, Lehrke M, Swirski FK, Marx N, Kahles F. Gut immune cells-A novel therapeutical target for cardiovascular disease? Front Cardiovasc Med. 2022;9:943214. Pubmed
Gencer S, Döring Y, Jansen Y, Bayasgalan S, Yan Y, Bianchini M, Cimen I, Muller M, Peters LJF, Megens RTA, von Hundelshausen P, Duchene J, Lemnitzer P, Soehnlein O, Weber C, van der Vorst EPC (2022). Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium. Basic Res Cardiol. 117:30. PMID 35674847. [A1, A2, A6, A10, Z1]
Georgakis MK, Bernhagen J, Heitmann J, Weber C, Dichgans M (2022). Targeting the CCL2-CCR2 axis for atheroprotection. Eur Heart J. (in press) [A1, A3, A10, B3]
Giroud M, Jodeleit H, Prentice KJ, Bartelt A (2022). Adipocyte function and the development of cardiometabolic disease. J Physiol. 600:1189-1208. PMID 34555180. [B10]
Habenicht LKL, Wang Z, Zhang X, Li Y, Mogler C, Huspenina JS, Schmid RM, Weber C, Mohanta SK, Ma Z, Yin C (2022). The C1q-ApoE complex: A new hallmark pathology of viral hepatitis and nonalcoholic fatty liver disease. Front Immunol. 13:970938. PMID 36304458. [A1, A10, Z1]
Haghikia A, Zimmermann F, Schumann P, Jasina A, Roessler J, Schmidt D, Heinze P, Kaisler J, Nageswaran V, Aigner A, Ceglarek U, Cineus R, Hegazy AN, van der Vorst EPC, Döring Y, Strauch CM, Nemet I, Tremaroli V, Dwibedi C, Krankel N, Leistner DM, Heimesaat MM, Bereswill S, Rauch G, Seeland U, Soehnlein O, Muller DN, Gold R, Backhed F, Hazen SL, Haghikia A, Landmesser U (2022). Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism. Eur Heart J. 43:518-533. PMID 34597388. [A1, A6]
Heuschkel MA, Babler A, Heyn J, van der Vorst EPC, Steenman M, Gesper M, Kappel BA, Magne D, Goueffic Y, Kramann R, Jahnen-Dechent W, Marx N, Quillard T, Goettsch C (2022). Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro. Front Cardiovasc Med. 9:959457. PMID 36204585.
Immler R, Nadolni W, Bertsch A, Morikis V, Rohwedder I, Masgrau-Alsina S, Schroll T, Yevtushenko A, Soehnlein O, Moser M, Gudermann T, Barnea ER, Rehberg M, Simon SI, Zierler S, Pruenster M, Sperandio M (2022). The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation. Cardiovasc Res. 118:1289-1302. PMID 33881519. [A6]
Kahles F, Rau M, Reugels M, Foldenauer AC, Mertens RW, Arrivas MC, Schroder J, Idel P, Moellmann J, van der Vorst EPC, Marx N, Lehrke M (2022). The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury. Cardiovasc Diabetol. 21:18. PMID 35123462.
Karshovska E, Mohibullah R, Zhu M, Zahedi F, Thomas D, Magkrioti C, Geissler C, Megens RTA, Bianchini M, Nazari-Jahantigh M, Ferreiros N, Aidinis V, Schober A (2022). ENPP2 (Endothelial Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) increases atherosclerosis in female and male mice. Arterioscler Thromb Vasc Biol. 42:1023-1036. PMID 35708027. [B4, Z1]
Kleist CJ, Choe CU, Atzler D, Schonhoff M, Boger R, Schwedhelm E, Wicha SG (2022). Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction. Amino Acids. 54:889-896. PMID 35618975. [A5]
Koenen RR, Weber C (2022). Jam-A unleashed incites thromboinflammatory coronary artery disease. JACC Basic Transl Sci. 7:462-464. PMID 35663635. [A1, A10]
Kotschi S, Jung A, Willemsen N, Ofoghi A, Proneth B, Conrad M, Bartelt A (2022). NFE2L1-mediated proteasome function protects from ferroptosis. Mol Metab. 57:101436. PMID 34999280. [B10]
Kichi ZA, Natarelli L, Sadeghian S, Boroumand MA, Behmanesh M, Weber C (2022). Orphan GPR26 counteracts early phases of hyperglycemia-mediated monocyte activation and is suppressed in diabetic patients. Biomedicines. 10:1736. PMID 35885041. [A1, A10]
Leberzammer J, Agten SM, Blanchet X, Duan R, Ippel H, Megens RTA, Schulz C, Aslani M, Duchêne J, Döring Y, Jooss NJ, Zhang P, Brandl R, Stark K, Siess W, Jurk K, Heemskerk JWM, Hackeng TM, Mayo KH, Weber C, von Hundelshausen P (2022). Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood. In press.
Liedtke C, Nevzorova YA, Luedde T, Zimmermann H, Kroy D, Strnad P, Berres ML, Bernhagen J, Tacke F, Nattermann J, Spengler U, Sauerbruch T, Wree A, Abdullah Z, Tolba RH, Trebicka J, Lammers T, Trautwein C, Weiskirchen R (2022). Liver fibrosis - from mechanisms of injury to modulation of disease. Front Med (Lausanne). 8:814496. PMID 35087852. [A3]
Lip GYH, Rigby A, Weber C (2022). A rollercoaster plunge into 2022. Thromb Haemost. 122:1-4. PMID 35038759. [A1, A10]
Liu Y, Shi JZ, Jiang R, Liu SF, He YY, van der Vorst EPC, Weber C, Döring Y, Yan Y (2022). Regulatory T cell-related gene indicators in pulmonary hypertension. Front Pharmacol. 13:908783. PMID 35712711. [A1, A10]
Matta L, de Faria CC, De Oliveira DF, Andrade IS, Lima-Junior NC, Gregorio BM, Takiya CM, Ferreira ACF, Nascimento JHM, de Carvalho DP, Bartelt A, Maciel L, Fortunato RS (2022). Exercise improves redox homeostasis and mitochondrial function in white adipose tissue. Antioxidants (Basel). 11:1689. PMID 36139762. [B10]
Mishra et al. (2022). Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 611:115-123. PMID 36180795.
Mohanta SK, Peng L, Li Y, Sun T, Lu S, Yin C, Carnevale L, Perrotta M, Ma Z, Förstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Ertürk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, Eckstein HH, Kleemann R, Habenicht L, Mallat Z, Michel J, Bernhagen J, Dichgans M, D´Agostino G, Guzik TJ, Olofsson PS, Weber C*, Lembo G*, Carnevale D*, Habenicht AJR* (2022). Neuroimmune cardiovascular interfaces control atherosclerosis. Nature. *equal contribution [A1, A3, A10, B3, B9, C2, Z1]
Mohanta SK, Weber C, Yin C, Habenicht AJR (2022). The dawn has come for new therapeutics to treat atherosclerosis: Targeting neuroimmune cardiovascular interfaces in artery brain circuits. Clin Transl Med. 12:e1040. PMID 36052959. [A1, A10, Z1]
Nardi V, Franchi F, Prasad M, Fatica EM, Alexander MP, Bois MC, Lam J, Singh RJ, Meyer FB, Lanzino G, Xiong Y, Lutgens E, Lerman LO, Lerman A (2022). Uric acid expression in carotid atherosclerotic plaque and serum uric acid are associated with cerebrovascular events. Hypertension. 79:1814-1823. PMID 35656807. [A5]
Natarelli L, Weber C (2022). A non-canonical link between non-coding RNAs and cardiovascular diseases. Biomedicines. 10. PMID 35203652. [A1, A10]
Nitz K, Lacy M, Bianchini M, Wichapong K, Kucukgoze IA, Bonfiglio CA, Migheli R, Wu Y, Burger C, Li Y, Forne I, Ammar C, Janjic A, Mohanta S, Duchene J, Heemskerk JWM, Megens RTA, Schwedhelm E, Huveneers S, Lygate CA, Santovito D, Zimmer R, Imhof A, Weber C, Lutgens E, Atzler D (2022). The amino acid homoarginine inhibits atherogenesis by modulating T-Cell function. Circ Res. PMID 36102188. [A1, A5, A10, B5, Z1, Z2]
Ouweneel AB, Reiche ME, Snip OSC, Wever R, van der Wel EJ, Schaftenaar FH, Kauerova S, Lutgens E, Van Eck M, Hoekstra M (2022). Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis. J Cell Sci. 135. PMID 34698355. [A5]
Pattarabanjird T, Marshall M, Upadhye A, Srikakulapu P, Garmey J, Haider A, Taylor AM, Lutgens E, McNamara CA (2022). B-1b cells possess unique bHLH-driven P62-dependent self-renewal and atheroprotection. Circ Res. 130:981-993. PMID 35209718. [A5]
Peters LJF, Baaten C, Maas SL, Lu C, Nagy M, Jooss NJ, Bidzhekov K, Santovito D, Moreno-Andres D, Jankowski J, Biessen EAL, Döring Y, Heemskerk JWM, Weber C, Kuijpers MJE, van der Vorst EPC (2022). MicroRNA-26b attenuates platelet adhesion and aggregation in mice. Biomedicines. 10:983. PMID 35625720. [A1, A10, B5]
Poelman H, Ippel H, Gurkan B, Boelens R, Vriend G, Veer CV, Lutgens E, Nicolaes GAF (2022). Structural anomalies in a published NMR-derived structure of IRAK-M. J Mol Graph Model. 111:108061. PMID 34837785. [A5]
Poels K, Schreurs M, Jansen M, Vugts DJ, Seijkens TTP, van Dongen G, Lutgens E, Beaino W (2022). Immuno-PET imaging of atherosclerotic plaques with [(89)Zr]Zr-Anti-CD40 mAb-proof of concept. Biology (Basel). PMID 35336782. [A5]
Rot A, Gutjahr JC, Biswas A, Aslani M, Hub E, Thiriot A, von Andrian UH, Megens RTA, Weber C, Duchene J (2022). Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1. Cell Stem Cell. 29:1013-1015. [A1, A10, Z1]
Santovito D, Weber C (2022). Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease. Nat Rev Cardiol. PMID 35304600. [A1, A10, B5]
Steffens S, Nahrendorf M, Madonna R (2022). Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies. Eur Heart J. ehab842. PMID 34897403. [B9]
Sun T, Li Y, Förstera B, Stanic K, Lu S, Steffens S, Yin C, Ertürk A, Megens RTA, Weber C, Habenicht A, Mohanta SK (2022). Tissue clearing approaches in atherosclerosis. Methods Mol Biol. 2419:747-763. PMID 35237999. [A1, A10, B9, C2, Z1]
Taş K, Volta BD, Lindner C, El Bounkari O, Hille K, Tian Y, Puig-Bosch X, Ballmann M, Hornung S, Ortner M, Prem S, Meier L, Rammes G, Haslbeck M, Weber C, Megens RTA, Bernhagen J, Kapurniotu A (2022). Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly. Nat Commun. 13:5004. PMID 36008417. [A1, A2, A3, A10, Z1]
Van der Velden J, Asselbergs FW, Bakkers J, Batkai S, Bertrand L, Bezzina CR, Bot I, Brundel B, Carrier L, Chamuleau S, Ciccarelli M, Dawson D, Davidson SM, Dendorfer A, Duncker DJ, Eschenhagen T, Fabritz L, Falcao-Pires I, Ferdinandy P, Giacca M, Girao H, Gollmann-Tepekoylu C, Gyongyosi M, Guzik TJ, Hamdani N, Heymans S, Hilfiker A, Hilfiker-Kleiner D, Hoekstra AG, Hulot JS, Kuster DWD, van Laake LW, Lecour S, Leiner T, Linke WA, Lumens J, Lutgens E, Madonna R, Maegdefessel L, Mayr M, van der Meer P, Passier R, Perbellini F, Perrino C, Pesce M, Priori S, Remme CA, Rosenhahn B, Schotten U, Schulz R, Sipido K, Sluijter JPG, van Steenbeek F, Steffens S, Terracciano CM, Tocchetti CG, Vlasman P, Yeung KK, Zacchigna S, Zwaagman D, Thum T (2022). Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res. cvab370. PMID 34999816. [A5, B5, B9]
Van der Vorst EPC, Lecour S (2022). Finding the culprit for the failure of the immune clock as time goes by. Cardiovasc Res. PMID 36065125.
Wang Z, Zhang X, Zhang C, Li Y, Lu S, Mohanta SK, Weber C, Habenicht A, Yin C (2022). Combined single-cell RNA and single-cell α/β T cell receptor sequencing of the arterial wall in atherosclerosis. Methods Mol Biol. 2419:727-746. PMID 35237998. [A1, A10, C2]
Weber C, Rigby A, Lip GYH (2022). Thrombosis and Haemostasis 2021 Editors' Choice Papers. Thromb Haemost. 122:163-170. PMID 35038760. [A1, A10]
Willemsen N, Arigoni I, Studencka-Turski M, Kruger E, Bartelt A (2022). Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3. Mol Metab. 101518. PMID 35636710. [B10]
Willemsen N, Kotschi S, Bartelt A (2022). Fire up the pyre: inosine thermogenic signaling for obesity therapy. Signal Transduct Target Ther. 7:375. PMID 36357366. [B10]
Wollenhaupt J, Frisch J, Harlacher E, Wong DWL, Jin H, Schulte C, Vondenhoff S, Moellmann J, Klinkhammer BM, Zhang L, Baleanu-Curaj A, Liehn EA, Speer T, Kazakov A, Werner C, van der Vorst EPC, Selejan SR, Hohl M, Bohm M, Kramann R, Biessen EAL, Lehrke M, Marx N, Jankowski J, Maack C, Boor P, Prates Roma L, Noels H (2022). Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease. Redox Biol. 56:102459. PMID 36099852.
Yerly A, van der Vorst EPC, Baumgartner I, Bernhard SM, Schindewolf M, Döring Y (2022). Sex-specific and hormone-related differences in vascular remodeling in atherosclerosis. Eur J Clin Invest. e13885. PMID 36219492. [A1]
Zhang X, Wang Z, Zhang C, Li Y, Lu S, Steffens S, Mohanta SK, Weber C, Habenicht A, Yin C (2022). Laser capture microdissection-based mRNA expression microarrays and single-cell RNA sequencing in atherosclerosis research. Methods Mol Biol. 2419:715-726. PMID 35237997. [A1, A10, B9, C2]