Publications 2020

Adrover JM, Aroca-Crevillén A, Crainiciuc G, Ostos F, Rojas-Vega Y, Rubio-Ponce A, Cilloniz C, Bonzón-Kulichenko E, Calvo E, Rico D, Moro MA, Weber C, Lizasoaín I, Torres A, Ruiz-Cabello J, Vázquez J, Hidalgo A (2020). Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation. Nat Immunol. 21:135-144. PMID 31932813. [A1, A10]

Alabert C, Loos C, Voelker-Albert M, Graziano S, Forné I, Reveron-Gomez N, Schuh L, Hasenauer J, Marr C, Imhof A, Groth A (2020). Domain model explains propagation dynamics and stability of histone H3K27 and H3K36 meth-ylation landscapes. Cell Rep. 30:1223-1234.e8. PMID 31995760. [Z2]

Armiento V, Hille K, Naltsas D, Lin JS, Barron AE, Kapurniotu A (2020). The human host-defense peptide catheli-cidin LL-37 is a nanomolar inhibitor of amyloid self-assembly of islet amyloid polypeptide (IAPP). Angew Chem Int Ed Engl. 59:12837-12841. PMID 31999880. [A3]

Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M (2020). Histone deacetylase 9 activates IKK to regulate athero-sclerotic plaque vulnerability. Circ Res. 127:811-823. PMID 32546048. [A3, A6, B3, B5, C1, Z1]

Asare Y*#, Koehncke J*, Selle J, Simsekyilmaz S, Jankowski J, Shagdarsuren G, Gessner JE, Bernhagen J#, Shagdarsuren E# (2020b). Differential role of activating FcγRIII in neointima formation after arterial injury and diet-induced atherosclerosis in apolipoprotein E-deficient mice. Front Physiol. 11:673 (#senior authorship). PMID 32625118. [A3, B3]

Baardman J, Lutgens E (2020). Regulatory T Cell metabolism in atherosclerosis. Metabolites. 10:279. PMID 32650487. [A5]

Baardman J, Verberk SGS, van der Velden S, Gijbels MJJ, van Roomen C, Sluimer JC, Broos JY, Griffith GR, Prange KHM, van Weeghel M, Lakbir S, Molenaar D, Meinster E, Neele AE, Kooij G, de Vries HE, Lutgens E, Wellen KE, de Winther MPJ, Van den Bossche J (2020). Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques. Nat Commun. 11:6296. PMID 33293558. [A5]

Baehr A, Hinkel R, Kupatt C (2020). Statins make a difference in acute myocardial infarction: a revival. J Am Coll Cardiol. 75:1403-1405. PMID 32216908. [C3]

Baehr A, Umansky KB, Bassat E, Jurisch V, Klett K, Bozoglu T, Hornaschewitz N, Solyanik O, Kain D, Ferraro B, Cohen-Rabi R, Krane M, Cyran C, Soehnlein O, Laugwitz KL, Hinkel R, Kupatt C, Tzahor E (2020). Agrin promotes coordinated therapeutic processes leading to improved cardiac repair in pigs. Circulation. 142:868-881. PMID 32508131. [A6, B5, C3]

Ballesteros I, Rubio-Ponce A, Genua M, Lusito E, Kwok I, Fernández-Calvo G, Khoyratty TE, van Grinsven E, González-Hernández S, Nicolás-Ávila JÁ, Vicanolo T, Maccataio A, Benguría A, Li JL, Adrover JM, Aroca-Crevillen A, Quintana JA, Martín-Salamanca S, Mayo F, Ascher S, Barbiera G, Soehnlein O, Gunzer M, Ginhoux F, Sánchez-Cabo F, Nistal-Villán E, Schulz C, Dopazo A, Reinhardt C, Udalova IA, Ng LG, Ostuni R, Hidalgo A (2020). Co-option of neutrophil fates by tissue environments. Cell. 183:1282-1297.e18. PMID 33098771. [A6, A7, B5]

Bartelt A, Weber C (2020). Mitochondrial ejection for cardiac protection: the macrophage connection. Cell Metab. 32:512-513. PMID 33027673. [A1, A10, B10]

Bartelt A, Widenmaier SB (2020). Proteostasis in thermogenesis and obesity. Biol Chem. 401:1019-1030. PMID 32061163. [B10]

Bosch L, de Haan JJ, Seijkens TTP, van Tiel CM, Brans MAD, Pasterkamp G, Lutgens E, de Jager SCA (2020). The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular diseases. Int J Cardiol. 300:220. PMID 31928651. [A5]

Butt E, Stempfle K, Lister L, Wolf F, Kraft M, Herrmann AB, Viciano CP, Weber C, Hochhaus A, Ernst T, Hoffmann C, Zernecke A, Frietsch JJ (2020). Phosphorylation-dependent differences in CXCR4-LASP1-AKT1 interaction between breast cancer and chronic myeloid leukemia. Cells. 9:444. PMID 32075106. [A1, A4, A10]

Cosco ED, Spearman AL, Ramakrishnan S, Lingg JGP, Saccomano M, Pengshung M, Arús BA, Wong KCY, Glasl S, Ntziachristos V, Warmer M, McLaughlin RR, Bruns OT*, Sletten EM* (2020). Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time. Nat Chem. 12:1123-1130. PMID 33077925. [B10, Z1]

Csaba G, Berchtold E, Hadziahmetovic A, Gruber M, Ammar C, Zimmer R (2020). EmpiReS: differential analysis of gene expression and alternative splicing. bioRxiv. doi: 10.1101/2020.08.23.234237. [Z2]

Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, Környei Z, Tóth K, Szabadits E, Sperlágh B, Baranyi M, Csiba L, Hortobágyi T, Maglóczky Z, Martinecz B, Szabó G, Erdélyi F, Szipőcs R, Tamkun MM, Gesierich B, Duering M, Katona I, Liesz A, Tamás G, Dénes Á (2020). Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science. 367:528-537. PMID 31831638. [C1]

d'Alessandro E, Becker C, Bergmeier W, Bode C, Bourne JH, Brown H, Buller HR, Ten Cate-Hoek AJ, Ten Cate V, van Cauteren YJM, Cheung YFH, Cleuren A, Coenen D, Crijns H, de Simone I, Dolleman SC, Klein CE, Fernandez DI, Granneman L, van THA, Henke P, Henskens YMC, Huang J, Jennings LK, Jooss N, Karel M, van den Kerkhof D, Klok FA, Kremers B, Lämmle B, Leader A, Lundstrom A, Mackman N, Mannucci PM, Maqsood Z, van der Meijden PEJ, van Moorsel M, Moran LA, Morser J, van Mourik M, Navarro S, Neagoe RAI, Olie RH, van Paridon P, Posma J, Provenzale I, Reitsma PH, Scaf B, Schurgers L, Seelig J, Siegbahn A, Siegerink B, Soehnlein O, Soriano EM, Sowa MA, Spronk HMH, Storey RF, Tantiwong C, Veninga A, Wang X, Watson SP, Weitz J, Zeerleder SS, Ten Cate H (2020). Thrombo-inflammation in cardiovascular disease: an expert consensus document from the third Maastricht Consensus Conference on thrombosis. Thromb Haemost. 120:538-564. [A6, B5]

Daub S, Lutgens E, Münzel T, Daiber A (2020). CD40/CD40L and related signaling pathways in cardiovascular health and disease-Tthe pros and cons for cardioprotection. Int J Mol Sci. 21. PMID 33198327. [A5].

Denisov SS, Heinzmann ACA, Vajen T, Vries MHM, Megens RTA, Suylen D, Koenen RR, Post MJ, Ippel JH, Hackeng TM, Dijkgraaf I (2020). Tick saliva protein Evasin-3 allows for visualization of inflammation in arteries through interactions with CXC-Type chemokines deposited on activated endothelium. Bioconjug Chem. 31:948-955. PMID 32077689. [Z1]

Depuydt MAC, Prange KHM, Slenders L, Örd T, Elbersen D, Boltjes A, de Jager SCA, Asselbergs FW, de Borst GJ, Aavik E, Lönnberg T, Lutgens E, Glass CK, den Ruijter HM, Kaikkonen MU, Bot I, Slütter B, van der Laan SW, Yla-Herttuala S, Mokry M, Kuiper J, de Winther MPJ, Pasterkamp G (2020). Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics. Circ Res. 127:1437-1455. PMID 32981416. [A5]

Döring Y, Jansen Y, Cimen I, Aslani M, Gencer S, Peters LJF, Duchêne J, Weber C*, van der Vorst EPC* (2020). B-cell specific CXCR4 protects against atherosclerosis development and increases plasma IgM levels. Circ Res. 126:787-788. PMID 32078474. *equal contribution. [A1, A10, C2]

Döring Y, Libby P, Soehnlein O (2020). Neutrophil extracellular traps participate in cardiovascular diseases: recent experimental and clinical insights. Circ Res. 126:1228-1241. PMID 32324499. [A1, A6, B5]

Döring Y, Noels H, van der Vorst E, Weber C (2020). Seeing is repairing: how imaging-based timely interference with CXCR4 could improve repair after myocardial infarction. Eur Heart J. 41:3576-3578. PMID 32918455. [A1, A10]

Dweck MR, Maurovich-Horvat P, Leiner T, Cosyns B, Fayad ZA, Gijsen FJH, Van der Heiden K, Kooi ME, Maehara A, Muller JE, Newby DE, Narula J, Pontone G, Regar E, Serruys PW, van der Steen AFW, Stone PH, Waltenberger JL, Yuan C, Evans PC, Lutgens E, Wentzel JJ, Bäck M (2020). Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a position paper from the European society of cardiology working group on atherosclerosis and vascular biology and the european association of cardiovascular imaging. Eur Heart J Cardiovasc Imaging. 21:1177-1183. PMID 32887997. [A5]

Eckardt V, Miller MC, Blanchet X, Duan R, Leberzammer J, Duchêne J, Soehnlein O, Megens RTA, Ludwig AK, Dregni A, Faussner A, Wichapong K, Ippel H, Dijkgraaf I, Kaltner H, Döring Y, Bidzhekov K, Hackeng TM, Weber C, Gabius HJ, von Hundelshausen P, Mayo KH (2020). Chemokines and galectins form heterodimers to modulate inflammation. EMBO Rep. 21:e47852. PMID 32080959. [A1, A2, A6, A10, B5, Z1]

Eckstein HH, Maegdefessel L (2020). Linking obesity with abdominal aortic aneurysm development. Eur Heart J. 41:2469-2471. PMID 31848586. [B5]

Evans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE, Fragiadaki M, Waltenberger J, Weber C, Bochaton-Piallat ML, Bäck M (2020). Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Cardiovasc Res. 116:2177-2184. PMID 32750108. [A1, A10]

Ferdinandy P, Koller Á, Weber C, Waltenberger J (2020). Postponement of frontiers in cardiovascular biomedicine (FCVB) 2020 due to COVID-19: a look forward to 2021. Cardiovasc Res. 116:e78-e81. PMID 32347928. [A1, A10]

Gencer S, Lacy M, Atzler D, van der Vorst EPC, Döring Y, Weber C (2020). Immunoinflammatory, thrombohaemostatic, and cardiovascular mechanisms in COVID-19. Thromb Haemost. 120:1629-1641. PMID 33124029. [A1, A5, A10]

Georgakis MK, de Lemos JA, Ayers C, Wang B, Björkbacka H, Pana AT, Thorand B, Sun C, Fani L, Malik R, Dupuis J, Engström G, Orho-Melander M, Melander O, Boekholdt M, Zierer A, Elhadad MA, Koenig W, Herder C, Hoogeveen RC, Kavousi M, Ballantyne CM, Peters A, Myint PK, Nilsson J, Benjamin EJ, Dichgans M (2020). Association of circulating monocyte chemoattractant protein-1 levels with cardiovascular mortality: a meta-analysis of population-based studies. JAMA Cardiol. 6:587-592. PMID 33146689. [B3]

Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L, Long M, Parry S, Woods R, Hulston C, Benedikter B, Niespolo C, Bazaz R, Francis S, Kiss-Toth E, van Zandvoort M, Schober A, Hellewell P, Evans PC, Ridger V (2020). Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nat Commun. 11:214. PMID 31924781. [B4]

Greiffo FR, Viteri-Alvarez V, Frankenberger M, Dietel D, Ortega-Gomez A, Lee JS, Hilgendorff A, Behr J, Soehnlein O, Eickelberg O, Fernandez IE (2020). CX3CR1-fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases. Eur Respir J. 55:1900460. PMID 31744836. [A6, B5]

Hamid SM, Citir M, Terzi EM, Cimen I, Yildirim Z, Dogan AE, Kocaturk B, Onat UI, Arditi M, Weber C, Traynor-Kaplan A, Schultz C, Erbay E (2020). Inositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth. EMBO Rep. 21:e51462. [A1, A7, A10]

Hasan SS, Jabs M, Tayler J, Wiedmann L, Leibing T, Nordström V, Federico G, Roma LP, Carlein C, Wolff G, Ekim-Üstünel B, Brune M, Moll I, Tetzlaff F, Gröne HJ, Fleming T, Géraud C, Herzig S, Nawroth PP, Fischer A (2020). Endothelial Notch signaling controls insulin transport in muscle. EMBO Mol Med. 12:e09271. PMID 32187826. [B9]

Hinkel R, Ramanujam D, Kaczmarek V, Howe A, Klett K, Beck C, Dueck A, Thum T, Laugwitz KL, Maegdefessel L, Weber C, Kupatt C, Engelhardt S (2020). AntimiR-21 prevents myocardial dysfunction in a pig model of ischemia/reperfusion injury. J Am Coll Cardiol. 75:1788-1800. PMID 32299591. [A1, A10, B5, C3]

Hoffmann A, Bernhagen J (2020). Revisiting the secretion mechanism(s) of macrophage migration inhibitory factor-welcome to the "UPS club". Immunol Cell Biol. 98:704-708. PMID 32894889. [A3]

Hoffmann A, Zwissler LC, El Bounkari O, Bernhagen J* (2020). Studying the pro-migratory effects of MIF. Methods Mol Biol. 2080:1-18. PMID 31745866. [A3]

Karshovska E, Wei Y, Subramanian P, Mohibullah R, Geissler C, Baatsch I, Popal A, Corbalan Campos J, Exner N, Schober A (2020). Hif-1alpha (hypoxia-inducible factor-1alpha) promotes macrophage necroptosis by regulating miR-210 and miR-383. Arterioscler Thromb Vasc Biol. 40:583-596. PMID 31996026. [B4]

Kessler T, Graf T, Hilgendorf I, Rizas K, Martens E, von Zur Mühlen C, Kraemer P, Meyer-Saraei R, Neumann FJ, Bode C, Laugwitz KL, Massberg S, Schunkert H, Weil J, Kastrati A, Sager HB (2020). Hospital admissions with acute coronary syndromes during the COVID-19 pandemic in German cardiac care units. Cardiovasc Res. 116:1800-1801. PMID 32637995. [B2, B6, C1]

Kessler T, Schunkert H, von Hundelshausen P (2020). Novel approaches to fine-tune therapeutic targeting of platelets in atherosclerosis: a critical appraisal. Thromb Haemost. 120:1492-1504. PMID 32772352. [A2, B2]

Kim BS, Tilstam PV, Arnke K, Leng L, Ruhl T, Piecychna M, Schulte W, Sauler M, Frueh FS, Storti G, Lindenblatt N, Giovanoli P, Pallua N, Bernhagen J, Bucala R (2020). Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF-2 in adipose tissue during endotoxemia. FASEB J. 34:4219-4233. PMID 31961019. [A3]

Kiouptsi K, Pontarollo G, Todorov H, Braun J, Jäckel S, Koeck T, Bayer F, Karwot C, Karpi A, Gerber S, Jansen Y, Wild P, Ruf W, Daiber A, van der Vorst E, Weber C, Döring Y, Reinhardt C (2020). Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice. Gut Microbes. 11:1809-1823. PMID 32579470. [A1, A10, C2]

Kochanova NY, Schauer T, Mathias GP, Lukacs A, Schmidt A, Flatley A, Schepers A, Thomae AW, Imhof A (2020). A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation. Nucleic Acids Res. 225:912. PMID 32182352. [Z2]

Kontos C, El Bounkari O, Krammer C, Sinitski D, Hille K, Zan C, Yan G, Wang S, Gao Y, Brandhofer M, Megens RTA, Hoffmann A, Pauli J, Asare Y, Gerra S, Bourilhon P, Leng L, Eckstein HH, Kempf WE, Pelisek J, Gokce O, Maegdefessel L, Bucala R, Dichgans M, Weber C, Kapurniotu A*, Bernhagen J* (2020). Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting. Nat Com-mun. 11:5981. PMID 33239628 *shared corresponding authors. [A1, A3, A4, A10, B3, B5]

Kopczak A, Schindler A, Bayer-Karpinska A, Koch ML, Sepp D, Zeller J, Strecker C, Hempel JM, Yuan C, Malik R, Wollenweber FA, Boeckh-Behrens T, Cyran CC, Helck A, Harloff A, Ziemann U, Poli S, Poppert H, Dichgans M#, Saam T# (2020). Complicated carotid artery plaques as a cause of cryptogenic stroke. J Am Coll Cardiol. 76:2212-2222. PMID 33153580. #shared corresponding authors [B3]

Lip GYH, Rigby A, Weber C (2020). A toast to the last decade and a very happy 2020 from thrombosis and haemostasis! Thromb Haemost. 120:1-4. PMID 31931535. [A1, A10]

Lu HS, Schmidt AM, Hegele RA, Mackman N, Rader DJ, Weber C, Daugherty A (2020). Annual report on sex in preclinical studies: arteriosclerosis, thrombosis, and vascular biology publications in 2018. Arterioscler Thromb Vasc Biol. 40:e1-e9. PMID 31869272. [A1, A10]

Lutgens E (2020). rs1883832: a CD40 single-nucleotide polymorphism for predicting coronary heart disease in humans. Cardiovasc Res. 116:1095-1096. PMID 31722420. [A5]

Lutgens E, Seijkens TTP (2020). Cancer patients receiving immune checkpoint inhibitor therapy are at an increased risk for atherosclerotic cardiovascular disease. J Immunother Cancer. 8:e000300. PMID 32034065. [A5]

Marquez AB, Nazir S, van der Vorst EPC (2020). High-density lipoprotein modifications: a pathological consequence or cause of disease progression? Biomedicines. 8:549. PMID 33260660. [C2]

Minderjahn J, Schmidt A, Fuchs A, Schill R, Raithel J, Babina M, Schmidl C, Gebhard C, Schmidhofer S, Mendes K, Ratermann A, Glatz D, Nützel M, Edinger M, Hoffmann P, Spang R, Längst G, Imhof A, Rehli M (2020). Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1. Nat Commun. 11:402. PMID 31964861. [Z2]

Nazir S, Jankowski V, Bender G, Zewinger S, Rye KA, van der Vorst EPC (2020). Interaction between high-density lipoproteins and inflammation: function matters more than concentration! Adv Drug Deliv Rev. 159:94-119. PMID 33080259. [C2]

Nicolai L, Leunig A, Brambs S, Kaiser R, Weinberger T, Weigand M, Muenchhoff M, Hellmuth JC, Ledderose S, Schulz H, Scherer C, Rudelius M, Zoller M, Höchter D, Keppler O, Teupser D, Zwißler B, von Bergwelt-Baildon M, Kääb S, Massberg S, Pekayvaz K, Stark K (2020). Immunothrombotic dysregulation in COVID-19 pneumonia is associated with respiratory failure and coagulopathy. Circulation. 142:1176-1189. PMID 32755393. [A7, B1, B6]

Nicolai L, Schiefelbein K, Lipsky S, Leunig A, Hoffknecht M, Pekayvaz K, Raude B, Marx C, Ehrlich A, Pircher J, Zhang Z, Saleh I, Marel AK, Löf A, Petzold T, Lorenz M, Stark K, Pick R, Rosenberger G, Weckbach L, Uhl B, Xia S, Reichel CA, Walzog B, Schulz C, Zheden V, Bender M, Li R, Massberg S, Gaertner F (2020). Vascular surveillance by haptotactic blood platelets in inflammation and infection. Nat Commun. 11:5778. PMID 33188196. [A7, B6]

Novotny J, Oberdieck P, Titova A, Pelisek J, Chandraratne S, Nicol P, Hapfelmeier A, Joner M, Maegdefessel L, Poppert H, Pircher J, Massberg S, Friedrich B, Zimmer C, Schulz C, Boeckh-Behrens T (2020). Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction. Neurology. 94:e2346-e2360. PMID 32434865. [A7, B5, B6]

Ortega-Gomez A, Soehnlein O (2020). Lack of proteinase 3 stabilizes advanced atherosclerotic lesions. Thromb Haemost. 120:994-997. PMID 32403136. [A6, B5]

Peters LJF, Biessen EAL, Hohl M, Weber C, van der Vorst EPC, Santovito D (2020). Small things matter: relevance of microRNAs in cardiovascular disease. Front Physiol. 11:793. PMID 32733281. [A1, A10, C2]

Peters LJF, Floege J, Biessen EAL, Jankowski J, van der Vorst EPC (2020). MicroRNAs in chronic kidney disease: four candidates for clinical application. Int J Mol Sci. 21. PMID 32906849. [C2]

Pleitez, MA, Ali Khan A, Solda A, Chmyrov A, Reber J, Gasparin F, Seeger M, Schätz B, Herzig S, Scheideler M, Ntziachristos V (2020). Label-free metabolic imaging by mid-infrared optoacoustic microscopy in living cells. Nat Biotechnol. 38:293-296. PMID 31873214. [B9, Z1]

Poels K, van Leent MMT, Boutros C, Tissot H, Roy S, Meerwaldt AE, Toner YCA, Reiche ME, Kusters PJH, Malinova T, Huveneers S, Kaufman AE, Mani V, Fayad ZA, de Winther MPJ, Marabelle A, Mulder WJM, Robert C, Seijkens TTP, Lutgens E (2020). Immune checkpoint inhibitor therapy aggravates T cell–driven plaque inflammation in atherosclerosis. JACC: CardioOncology. 2:599-610. PMID 34396271. [A5]

Poels K, Schnitzler JG, Waissi F, Levels JHM, Stroes ESG, Daemen M, Lutgens E, Pennekamp AM, De Kleijn DPV, Seijkens TTP, Kroon J (2020). Inhibition of PFKFB3 hampers the progression of atherosclerosis and promotes plaque stability. Front Cell Dev Biol. 8:581641. PMID 33282864. [A5]

Poels K, van Leent MMT, Reiche ME, Kusters PJH, Huveneers S, de Winther MPJ, Mulder WJM, Lutgens E, Seijkens TTP (2020). Antibody-mediated inhibition of CTLA4 aggravates atherosclerotic plaque inflammation and progression in hyperlipidemic mice. Cells. 9:1987. PMID 32872393. [A5]

Poels K, Vos WG, Lutgens E, Seijkens TTP (2020). E3 ubiquitin ligases as immunotherapeutic target in atherosclerotic cardiovascular disease. Front Cardiovasc Med. 7:106. PMID 32582770. [A5]

Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts S, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020). Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 112:413-426. PMID 32320006. [A5]

Rigby A, Lip GYH, Weber C (2020). Documenting sex and sex differences in animal studies. Thromb Haemost. 120:879-882. PMID 32369833. [A1, A10]

Sachs S, Bastidas-Ponce A, Tritschler S, Bakhti M, Böttcher A, Sánchez-Garrido MA, Tarquis-Medina M, Kleinert M, Fischer K, Jall S, Harger A, Bader E, Roscioni S, Ussar S, Feuchtinger A, Yesildag B, Neelakandhan A, Jensen CB, Cornu M, Yang B, Finan B, DiMarchi RD, Tschöp MH, Theis FJ, Hofmann SM, Müller TD, Lickert H (2020). Targeted pharmacological therapy restores β-cell function for diabetes remission. Nat Metab. 2:192-209. PMID 32694693. [A4]

Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen M, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C (2020). Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis. Sci Transl Med. 12:eaaz2294. PMID 32493793. [A1, A2, A5, A10, B9, Z1]

Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen M, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C (2020). Autophagy unleashes noncanonical microRNA functions. Autophagy. 16:2294-2296. PMID 33054575. [A1, A2, A5, A10, B9, Z1]

Santovito D, Marcantonio P, Mastroiacovo D, Natarelli L, Mandolini C, De Nardis V, Paganelli C, De Cesare D, Affaitati G, Giamberardino MA, Stellin L, Pinelli M, Weber C, De Blasis G, Occhiuzzi U, Bucci M, Desideri G, Cipollone F (2020). High dose rosuvastatin increases ABCA1 transporter in human atherosclerotic plaques in a cholesterol-independent fashion. Int J Cardiol. 299:249-253. PMID 31409515. [A1, A10]

Schilperoort M, van den Berg R, Bosmans LA, van Os BW, Dollé MET, Smits NAM, Guichelaar T, van Baarle D, Koemans L, Berbée JFP, Deboer T, Meijer JH, de Vries MR, Vreeken D, van Gils JM, Willems van Dijk K, van Kerkhof LWM, Lutgens E, Biermasz NR, Rensen PCN, Kooijman S (2020). Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice. J Pineal Res. 68:e12614. PMID 31599473. [A5]

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