SFB 1123 Atherosclerosis-Mechanisms and Networks of Novel Therapeutic Targets

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Publications 2015

Ahmadsei M, Lievens D, Weber C, von Hundelshausen P, Gerdes N (2015). Immune-mediated and lipid-mediated platelet function in atherosclerosis. Curr Opin Lipidol. 26:438-448. PMID 26270811. [A1, A2, A10]

Akhtar S, Hartmann P, Karshovska E, Rinderknecht F-A, Subramanian P, Gremse F, Grommes J, Jacobs M, Kiessling F, Weber C, Steffens S, Schober A (2015). Endothelial hypoxia-inducible factor-1 alpha promotes atherosclerosis and monocyte recruitment by upregulating microRNA-19a. Hypertension. 66:1220-1226. PMID 26483345. [A1, A10, B4, B9]

Alabert C, Barth TK, Reverón-Gómez N, Sidoli S, Schmidt A, Jensen ON, Imhof A, Groth A (2015). Two distinct modes for propagation of histone PTMs across the cell cycle. Genes Dev. 29:585-90. PMID 25792596. [Z2]

Alampour-Rajabi S, El Bounkari O, Rot A, Müller-Newen G, Bachelerie F, Gawaz M, Weber C, Schober A, Bernhagen J (2015). MIF interacts with CXCR7 to promote receptor internaliza-tion, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis. FASEB J. 29:4497-4511. PMID 26139098. [A1, A3, A10, B4]

Alard JE, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RTA, Leoni G, Ferraro B, Rossaint J, Paulin N, Ng J, Ippel H, Suylen D, Hinkel R, Blanchet X, Gaillard F, D’Amico M, von Hundelshausen P, Zarbock A, Scheiermann C, Hackeng TH, Steffens S, Kupatt C, Nicolaes GAF, Weber C, Soehnlein O (2015). Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. Sci Transl Med. 7:317ra196. PMID 26659570. [A1, A2, A6, A10, B5, B9, C3, Z1]

Andreetto E, Malideli E, Yan LM, Kracklauer M, Farbiarz K, Tatarek-Nossol M, Rammes G, Prade E, Neumüller T, Caporale A, Spanopoulou A, Bakou M, Reif B, Kapurniotu A (2015). A hot-segment-based approach for the design of cross-amyloid interaction surface mimics as inhibitors of amyloid self-assembly. Angew Chem Int Ed Engl. 54:13095-100. PMID 26336938. [A3]

Azghandi S, Prell C, van der Laan S, Schneider M, Malik R, Berer K, Gerdes N, Pasterkamp G, Weber C, Haffner C, Dichgans M (2015). Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1. Stroke. 46:197-202. PMID 25388417. [A1, A10, B3]

Bäck M, Weber C, Lutgens E (2015). Regulation of atherosclerotic plaque inflammation. J Intern Med. 278:462-82. PMID 25823439. [A1, A5, A10]

Berbée JF*, Boon MR*, Khedoe PP*, Bartelt A*#, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J#, Rensen PC# (2015). Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 6:6356. PMID 25754609 *shared first authors, #shared corresponding authors [B10]

Bernlochner I, Goedel A, Plischke C, Schüpke S, Haller B, Schulz C, Mayer K, Morath T, Braun S, Schunkert H, Siess W, Kastrati A, Laugwitz KL (2015). Impact of immature platelets on platelet response to ticagrelor and prasugrel in patients with acute coronary syndrome. Eur Heart J. 36:3202-10. PMID 26216931. [A7, B2]

Bürger C, Weber C, Lutgens E, Gerdes N (2015). Atherosclerosis: cell biology and lipoproteins-focus on CD40 signaling, PCSK9 and novel animal models. Curr Opin Lipidol. 26:245-246. PMID 25950709. [A1, A5, A10]

Clemmensen C, Finan B, Fischer K, Tom RZ, Legutko B, Sehrer L, Heine D, Grassl N, Meyer CW, Henderson B, Hofmann SM, Tschöp MH, van der Ploeg LHT, Müller TD (2015). Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice. EMBO Mol Med. 7:288-98. PMID 25652173. [A4]

Curaj A, Wu Z, Fokong S, Liehn EA, Weber C, Burlacu A, Lammers T, van Zandvoort M, Kiessling F (2015). Noninvasive molecular ultrasound monitoring of vessel healing after intravascular surgical procedures in a preclinical setup. Arterioscler Thromb Vasc Biol. 35:1366-73. PMID 25838431. [A1, A10]

Dickerhof N, Schindler L, Bernhagen J, Kettle AJ, Hampton MB (2015). Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myelo¬peroxidase-derived oxidants but retains its immunomodulatory function. Free Radic Biol Med. 89:498-511. PMID 26453918. [A3]

Döring Y (2015). Not growth but death: GM-CSF/IL-23 axis drives atherosclerotic plaque vulnerability by enhancing macrophage and DC apoptosis. Circ Res. 116:222-4. PMID 25593270. [A1]

Döring Y, Drechsler M, Soehnlein O, Weber C (2015). Neutrophils in atherosclerosis: from mice to man. Arterioscler Thromb Vasc Biol. 35:288-95. PMID 25147339. [A1, A6, A10, B5]

Drechsler M, Dûchene J, Soehnlein O (2015). Chemokines control mobilization, recruitment, and fate of monocytes in atherosclerosis. Arterioscler Thromb Vasc Biol. 35:1050-5. PMID 25792446. [A10, A6, B5]

Drechsler M, de Jong R, Rossaint J, Viola JR, Leoni G, Wang JM, Grommes J, Hinkel R, Kupatt C, Weber C, Döring Y, Zarbock A, Soehnlein O (2015). Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment. Circ Res. 116:827-35. PMID 25520364. [A1, A6, A10, B5, C3]

Dûchene J, von Hundelshausen P (2015). Platelet-derived chemokines in atherosclerosis. Hamostaseologie. 35:137-41. PMID 25592448. [A1, A2, A10]

Dutta P*, Sager HB*, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M (2015). Myocardial infarction activates CCR2(+) hematopoietic stem and progenitor cells. Cell Stem Cell. 16:477-87. PMID 25957903; *equal first authors [C1]

Erhard F, Halenius A, Zimmermann C, L'Hernault A, Kowalewski DJ, Weekes MP, Stevanovic S, Zimmer R, Dölken L (2015). Improved Ribo-seq enables identification of cryptic translation events. Nat Methods. 15:363-366. PMID 29529017. [Z2]

Erhard F, Zimmer R. Count ratio model reveals bias affecting NGS fold changes. Nucleic Acids Res. 43:e136. PMID 26160885. [Z2]

Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH (2015). A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nat Med. 21:27-36. PMID 25485909. [A4]

Gomez Perdiguero E, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, Garner H, Trouillet C, de Bruijn MF, Geissmann F, Rodewald HR (2015). Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature. 518:547-51. PMID 25470051. [A7]

GTEx Consortium (2015) Human genomics. The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 348:648-60. PMID 25954001.

Hartmann P, Schober A, Weber C (2015). Chemokines and microRNAs in atherosclerosis. Cell Mol Life Sci. 72:3253-66. PMID 26001902. [A1, A10, B4]

Hartwig H, Silvestre-Roig C, Hendrikse J, Beckers L, Paulin N, Van der Heiden K, Braster Q, Drechsler M, Daemen MJ, Lutgens E, Soehnlein O (2015). Atherosclerotic plaque destabilization in mice: a comparative study. PLoS One. 10:e0141019. PMID 26492161. [A5, A6, B5]

Hartwig H, Silvestre Roig C, Daemen M, Lutgens E, Soehnlein O (2015). Neutrophils in atherosclerosis. A brief overview. Hamostaseologie. 35:121-7. PMID 25385255. [A5, A6, B5]

Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C (2015). Heme Oxygenase-1 gene therapy provides cardioprotection via control of post-ischemic inflammation: an experimental study in a pre-clinical pig model. J Am Coll Cardiol. 66:154-65. PMID 26160631. [C3]

Hoefer IE, Steffens S, Ala-Korpela M, Bäck M, Badimon L, Bochaton-Piallat ML, Boulanger CM, Caligiuri G, Dimmeler S, Egido J, Evans PC, Guzik T, Kwak BR, Landmesser U, Mayr M, Monaco C, Pasterkamp G, Tuñón J, Weber C; ESC Working Group Atherosclerosis and Vascular Biology (2015). Novel methodologies for biomarker discovery in atherosclerosis. Eur Heart J. 36:2635-42. PMID 26049157. [A1, A10, B9]

Holdt LM, Teupser D (2015). Long noncoding RNA-MicroRNA pathway controlling nuclear factor IA, a novel atherosclerosis modifier gene. Arterioscler Thromb Vasc Biol. 35:7-8. PMID 25520519. [B1]

Hristov M, Weber C (2015). Myocardial infarction and inflammation: lost in the biomarker labyrinth. Circ Res. 116:781-783. PMID 25722440. [A1, A10]

Hu D*, Mohanta SK*, Yin C, Peng L, Ma Z, Srikakulapu P, Grassia G, MacRitchie N, Dever G, Gordon P, Burton FL, Ialenti A, Sabir SR, McInnes IB, Brewer JM, Garside P, Weber C, Lehmann T, Teupser D, Habenicht L, Beer M, Grabner R, Maffia P, Weih F, Habenicht AJR (2015). Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity. 42:1100-15. PMID 26084025. *shared first authors [A1, A10, B1, C2]

Ippel H, Miller MC, Berbís MA, Suylen D, André S, Hackeng TM, Cañada FJ, Weber C, Gabius HJ, Jiménez-Barbero J, Mayo KH (2015). 1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3. Biomol NMR Assign. 9:59-63. PMID 24504927. [A1, A10]

Jamasbi J, Megens RTA, Bianchini M, Münch G, Ungerer M, Faussner A, Sherman S, Walker A, Goyal P, Jung S, Brandl R, Weber C, Lorenz R, Farndale R, Elia N, Siess W (2015). Differential inhibition of human atherosclerotic plaque-induced platelet activation by Dimeric GPVI-Fc and Anti-GPVI antibodies: functional and imaging studies. J Am Coll Cardiol. 65:2404-15. PMID 26046734. [A1, A10, Z1]

Kälin S, Heppner FL, Bechmann I, Prinz M, Tschöp MH, Yi CX (2015). Hypothalamic innate immune reaction in obesity. Nat Rev Endocrinol. 11:339-51. PMID 25824676. [A4]

Karshovska E, Zhao Z, Blanchet X, Schmitt MM, Bidzhekov K, Soehnlein O, von Hundelshausen P, Mattheij NJ, Cosemans JM, Megens RTA, Koeppel TA, Schober A, Hackeng TM, Weber C, Koenen RR (2015). Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice. Circ Res. 116:587-99. PMID 25472975. [A1, A2, A5, A10, B6, Z1]

Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W (2015). ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling via cleavage of thrombospondin-1. Circulation. 131:1191-1201. PMID 25712208. [B2]

Klapproth S, Sperandio M, Pinheiro EM, Prünster M, Soehnlein O, Gertler FB, Fässler R, Moser M (2015). Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice. Blood. 126:2704-12. PMID 26337492. [A6, B5]

Kornmann LM, Zernecke A, Curfs DM, Janssen BJ, Weber C, de Winther MP, Reneman RS, Hoeks AP, Reesink KD (2015).Echogenic perfluorohexane-loaded macrophages adhere in vivo to activated vascular endothelium in mice, an explorative study. Cardiovasc Ultrasound. 13:1. PMID 25567641. [A1, A10]

Kuijpers MJ, Mattheij NJ, Cipolla L, van Geffen JP, Lawrence T, Donners MM, Boon L, Lievens D, Torti M, Noels H, Gerdes N, Cosemans JM, Lutgens E, Heemskerk JW (2015). Platelet CD40L Modulates thrombus growth via phosphatidylinositol 3-kinase β, and not via CD40 and IκB kinase α. Arterioscler Thromb Vasc Biol. 35:1374-81. PMID 25908768. [A5]

Kusters PJ, Lutgens E (2015). Cytokines and immune responses in murine atherosclerosis. Methods Mol Biol. 1339:17-40. PMID 26445779. [A5]

Legein B, Janssen EM, Theelen TL, Gijbels MJ, Walraven J, Klarquist JS, Hennies CM, Wouters K, Seijkens TT, Wijnands E, Sluimer JC, Lutgens E, Zenke M, Hildner K, Biessen EA, Temmerman L (2015). Ablation of CD8α(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice. Sci Rep. 5:15414. PMID 26486587. [A5]

Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, Giese T, Veltkamp R (2009). Regulatory T-cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med. 15:192-9. PMID 19169263. [C1]

Lip GY, Weber C (2015). A Happy New Year from Thrombosis and Haemostasis. A 5 year reflection from the editorial team. Thromb Haemost. 113:1-2. PMID 25567473. [A1, A10]

Llovera G, Hofmann K, Roth S, Sales- Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, de Simoni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A (2015). Results of the first preclinical randomized controlled (pRCT) multicenter trial: anti-CD49d treatment for acute brain ischemia. Science Transl Med. 7:299ra121. PMID 26246166. [C1]

Lundeberg E, Van Der Does AM, Kenne E, Soehnlein O, Lindbom L (2015). Assessing large-vessel endothelial permeability using near-infrared fluorescence imaging. Arterioscler Thromb Vasc Biol. 35:783-6. PMID 25675996. [A6, B5]

Mandl M, Drechsler M, Jansen Y, Neideck C, Noels H, Faussner A, Soehnlein O, Weber C, Döring Y (2015). Evaluation of the BDCA2-DTR transgenic mouse model in chronic and acute inflammation. PLoS One. 10:e0134176. PMID 26252890. [A1, A6, A10, B5]

Medina I, Cougoule C, Drechsler M, Bermudez B, Koenen RR, Sluimer J, Wolfs I, Döring Y, Herias V, Gijbels M, Bot I, de Jager SC, Weber C, Cleutjens J, van Berkel TJ, Sikkink KJ, Mócsai A, Maridonneau-Parini I, Soehnlein O, Biessen EA (2015). Hck/Fgr kinase deficiency reduces plaque growth and stability by blunting monocyte recruitment and intraplaque motility. Circulation. 132:490-501. PMID 26068045. [A1, A6, A10, B5]

Megens RTA, Bianchini M, Schmitt MM, Weber C (2015). Optical imaging innovations for atherosclerosis research: multiphoton microscopy and optical nanoscopy. Arterioscler Thromb Vasc Biol. 35:1339-46. PMID 25908769. [A1, A10, Z1]

Megens RTA, Soehnlein O (2015). Intravital microscopy for atherosclerosis research: methods in mouse atherosclerosis. Methods Mol Biol. 1339:41-60. PMID 26445780. [A6, B5, Z1]

Molica F, Morel S, Kwak BR, Rohner-Jeanrenaud F, Steffens S (2015). Adipokines at the crossroad between obesity and cardiovascular disease. Thromb Haemost. 113:553-66. PMID 25338625. [B9]

Natarelli L, Schober A (2015). MicroRNAs and the response to injury in atherosclerosis. Hamostaseologie. 35:142-50. PMID 25612846. [B4]

Nazari-Jahantigh M, Egea V, Schober A, Weber C (2015). MicroRNA-specific regulatory mechanisms in atherosclerosis. J Mol Cell Cardiol. 8:35-41. PMID 25450610. [A1, A10, B4]

Nikpay M, (60 authors), Kessler T, (83 authors), Watkins H*, Kathiresan S*, McPherson R*, Deloukas P*, Schunkert H*, Samani NJS*, Farrall M* (2015). A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 47:1121-1130. PMID 26343387. [B2]

Njock MS, Cheng HS, Dang LT, Nazari-Jahantigh M, Lau AC, Boudreau E, Roufaiel M, Cybulsky MI, Schober A, Fish JE (2015). Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing anti-inflammatory microRNAs. Blood. 125:3202-12. PMID 25838349. [B4]

Panstruga R, Baumgarten K, Bernhagen J (2015). Phylogeny and evolution of plant macrophage migration inhibitory factor/D-dopachrome tautomerase-like proteins. BMC Evol Biol. 15:64. PMID 25888527. [A3]

Pawig L, Klasen C, Weber C, Bernhagen J, Noels H (2015). Diversity and inter-connections in the CXCR4 chemokine receptor/ligand family: molecular perspectives. Front Immunol. 6:429. PMID 26347749. [A1, A3, A10]

Renz M, Otten C, Faurobert E, Rudolph F, Zhu Y, Boulday G, Dûchene J, Mickoleit M, Dietrich AC, Ramspacher C, Steed E, Manet-Dupé S, Benz A, Hassel D, Vermot J, Huisken J, Tournier-Lasserve E, Felbor U, Sure U, Albiges-Rizo C, Abdelilah-Seyfried S (2015). Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins. Dev Cell. 32:181-190. PMID 25625207. [A10]

Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M (2015). Targeting interleukin-1β reduces leukocyte production after acute myocardial infarction. Circulation. 132:1880-90. PMID 26358260. [C1]

Salem S, Jankowski V, Asare Y, Liehn E, Welker P, Raya-Bermudez A, Pineda-Martos C, Rodriguez M, Muñoz-Castañeda JR, Bruck H, Marx N, Machado FB, Staudt M, Heinze G, Zidek W, Jankowski J (2015). Identification of the vasoconstriction-inhibiting factor (VIF), a potent endogenous cofactor of angiotensin II acting on the angiotensin II type 2 receptor. Circulation. 131:1426-34. PMID 25810338.[B3]

Santovito D, Weber C (2015). Fibronectin extradomain A: balancing atherosclerotic plaque burden and stability. Thromb Haemost. 114:4. PMID 26062571. [A1, A10]

Santovito D, Egea V, Weber C (2015). Small but smart: Micrornas orchestrate atherosclerosis development and progression. Biochim Biophys Acta. 1861:2075-2086. PMID 26738655. [A1, A10]

Schober A, Nazari-Jahantigh M, Weber C (2015). MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis. Nat Rev Cardiol. 12:361-74. PMID 25855604. [A1, A10, B4]

Selle J, Asare Y, Köhncke J, Alampour-Rajabi S, Shagdarsuren G, Klos A, Weber C, Jankowski J, Shagdarsuren E (2015). Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice. Thromb Haemost. 114:848-58. PMID 26084965. [A1, A10, B3]

Soehnlein O, Ortega-Gómez A, Döring Y, Weber C (2015). Neutrophil-macrophage interplay in atherosclerosis: protease-mediated cytokine processing versus NET release. Thromb Haemost. 114:866-7. PMID 26310276. [A1, A6, A10, B5]

Soehnlein O (2015). (Re)solving atherosclerosis. Sci Transl Med. 7:275fs7. PMID 25695998. [A6, B5]

Steffens S, Pacher P (2015). The activated endocannabinoid system in atherosclerosis: driving force or protective mechanism? Curr Drug Targets. 16:334-41. PMID 25469884. [B9]

Stoppe C, Rex S, Goetzenich A, Kraemer S, Emontzpohl C, Soppert J, Averdunk L, Sun Y, Rossaint R, Lue H, Huang C, Song Y, Pantouris G, Lolis E, Leng L, Schulte W, Bucala R, Weber C, Bernhagen J (2015). Interaction of MIF family proteins in myocardial ischemia/reperfusion damage and their influence on clinical outcome of cardiac surgery patients. Antioxid Redox Signal. 23:865-879. PMID 26234719. [A1, A3, A10]

Taruttis A, van Dam GM, Ntziachristos V (2015). Mesoscopic and macroscopic optoacoustic imaging of cancer. Cancer Res. 75:1548-1559. PMID 25836718. [Z1]

Taruttis A, Ntziachristos V (2015). Advances in real-time multispectral optoacoustic imaging and its applications. Nat Photonics. 9:219-227. [Z1]

Van Dam AD, Nahon KJ, Kooijman S, van den Berg SM, Kanhai AA, Kikuchi T, Heemskerk MM, van Harmelen V, Lombès M, van den Hoek AM, de Winther MP, Lutgens E, Guigas B, Rensen PC, Boon MR (2015). Salsalate activates brown adipose tissue in mice. Diabetes. 64:1544-54.PMID 25475439. [A5]

Van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E (2015). Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond). 39:782-90. PMID 25394307. [A1, A5, A10]

Van der Vorst EP, Döring Y, Weber C (2015). Chemokines. Arterioscler Thromb Vasc Biol. 35:e52-56. PMID 26490276. [A1, A10, C2]

Van der Vorst EP, Döring Y, Weber C (2015). Chemokines and their receptors in atherosclerosis. J Mol Med (Berl). 93:963-971. PMID 26175090. [A1, A10, C2]

Van der Vorst EP, Döring Y, Weber C (2015). Mif and cxcl12 in cardiovascular diseases: functional differences and similarities. Front Immunol. 6:373. PMID 26257740. [A1, A10, C2]

Viola J, Soehnlein O (2015). Atherosclerosis - a matter of unresolved inflammation. Semin Immunol. 27:184-93. PMID 25865626. [A6, B5]

Von Hundelshausen P, Oexle K, Bidzhekov K, Schmitt MM, Hristov M, Blanchet X, Kaemmerer H, Matyas G, Meitinger T, Weber C (2015). Recurrent spontaneous coronary dissections in a patient with a de novo fibrillin-1 mutation without marfan syndrome. Thromb Haemost. 113:668-670. PMID 25519456. [A1, A2, A10]

Weber C, Hristov M (2015). Atherogenesis and inflammation. From cellular mediators to regulatory mechanisms of inflammation in atherosclerosis. Hamostaseologie. 35:99-101. PMID 25943077. [A1, A10]

Wei Y, Zhu M, Corbalan-Campos J, Heyll K, Weber C, Schober A (2015). Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microRNA-155 on atherosclerosis. Arterioscler Thromb Vasc Biol. 35:796-803. PMID 25810298. [A1, A10, B4]

Wertenbruch S, Drescher H, Grossarth V, Kroy D, Giebeler A, Erschfeld S, Heinrichs D, Soehnlein O, Trautwein C, Brandenburg LO, Streetz K (2015). The anti-microbial peptide LL-37/CRAMP is elevated in patients with liver diseases and acts as a protective factor during mouse liver injury. Digestion. 91:307-317. PMID 25998843. [A6, B5]

Wirtz TH, Tillmann S, Strüßmann T, Kraemer S, Heemskerk JW, Grottke O, Gawaz M, von Hundelshausen P, Bernhagen J (2015). Platelet-derived MIF: a novel platelet chemokine with distinct recruitment properties. Atherosclerosis. 239:1-10. PMID 25561410. [A2, A3]

Wobst J, Rumpf PM, Dang TA, Segura-Puimedon M, Erdmann J, Schunkert H (2015). Molecular variants of soluble guanylyl cyclase affecting cardiovascular risk. Circ J. 79:463-9. PMID 25746521. [B2]

Yamano T, Nedjic J, Hinterberger M, Steinert M, Koser S, Pinto S, Gerdes N, Lutgens E, Ishimaru N, Busslinger M, Brors B, Kyewski B, Klein L (2015). Thymic B cells are licensed to present self antigens for central T cell tolerance induction. Immunity. 42:1048-61. PMID 26070482. [A5]

Yin C, Mohanta SK, Ma Z, Weber C, Hu D, Weih F, Habenicht A (2015). Generation of aorta transcript atlases of wild-type and apolipoprotein E-null mice by laser capture microdissection-based mRNA expression microarrays. Methods Mol Biol. 1339:297-308. PMID 26445797. [A1, A10, C2]

Zarzycka B, Seijkens T, Nabuurs SB, Ritschel T, Grommes J, Soehnlein O, Schrijver R, van Tiel CM, Hackeng TM, Weber C, Giehler F, Kieser A, Lutgens E, Vriend G, Nicolaes GA (2015). Discovery of small molecule CD40-TRAF6 inhibitors. J Chem Inf Model. 55:294-307. PMID 25622654. [A1, A5, A6, A10, B5]

Zarzycka B, Nicolaes GA, Lutgens E (2015). Targeting the adaptive immune system: new strategies in the treatment of atherosclerosis. Expert Rev Clin Pharmacol. 8:297-313. PMID 25843158. [A5]

Zirlik A, Lutgens E (2015). An inflammatory link in atherosclerosis and obesity. Co-stimulatory molecules. Hamostaseologie. 35:272-8. PMID 26225729. [A5]