Publications 2014

Aoqui C, Chmielewski S, Scherer E, Eißler R, Sollinger D, Heid I, Braren R, Schmaderer C, Megens RTA, Weber C, Heemann U, Tschöp M, Baumann M (2014). Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet. Cardiovasc Diabetol. 13:31. PMID 24490784. [A1, A4, A10, Z1]

Assis DN, Leng L, Ling L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R (2014). The role of MIF in autoimmune liver disease. Hepatology. 59:580-591. PMID 23913513. [A3]

Atzler D, Gore MO, Ayers CR, Choe CU, Böger RH, de Lemos JA, McGuire DK, Schwedhelm E (2014). Homoarginine and cardiovascular outcome in the population-based Dallas Heart Study. Arterioscler Thromb Vasc Biol. 34:2501-7. PMID 25189571. [A5]

Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T (2014). Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 124:2136-46. PMID 24743145. [B4]

Bartelt A & Heeren J. (2014). Adipose tissue browning and metabolic health. Nat Rev Endocrinol. 10:24-36. PMID 24146030. [B10]

Blanchet X, Cesarek K, Brandt J, Herwald H, Teupser D, Küchenhoff H, Karshovska E, Mause SF, Siess W, Wasmuth H, Soehnlein O, Koenen RR, Weber C, von Hundelshausen P (2014). Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome. Thromb Haemost. 112:1277-87. PMID 25183015. [A1, A2, A6, A10, B1, B5]

Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte KM, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T, Lutgens E (2014). Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A. 111:2686-91. PMID 24492375. [A1, A5, A6, A10, B5]

Chatzigeorgiou A, Chung KJ, Garcia-Martin R, Alexaki VI, Klotzsche-von Ameln A, Phieler J, Sprott D, Kanczkowski W, Tzanavari T, Bdeir M, Bergmann S, Cartellieri M, Bachmann M, Nikolakopoulou P, Androutsellis-Theotokis A, Siegert G, Bornstein SR, Muders MH, Boon L, Karalis KP, Lutgens E, Chavakis T (2014). Dual role of B7 costimulation in obesity-related non-alcoholic steatohepatitis (NASH) and metabolic dysregulation. Hepatology. 60:1196-210. PMID 24845056. [A5]

Chèvre R, González-Granado JM, Megens RTA, Sreeramkumar V, Silvestre-Roig C, Molina-Sánchez P, Weber C, Soehnlein O, Hidalgo A, Andrés V (2014). High-resolution imaging of intravascular atherogenic inflammation in live mice. Circ Res. 114:770-9. PMID 24366169. [A1, A6, A10, B5, Z1]

De Winther MP, Lutgens E (2014). MiR-92a: at the heart of lipid-driven endothelial dysfunction. Circ Res. 114:399-401. PMID 24481837. [A5]

Döring Y, Noels H, Mandl M, Kramp B, Neideck C, Lievens D, Drechsler M, Megens RTA, Tilstam PV, Langer M, Hartwig H, Theelen W, Marth JD, Sperandio M, Soehnlein O, Weber C (2014). Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication. Circ Res. 114:976-81. PMID 24425712. [A1, A6, A10, B5, Z1]

Döring Y, Pawig L, Weber C, Noels H (2014). The cxcl12/cxcr4 chemokine ligand/receptor axis in cardiovascular disease. Front Physiol. 5:212. PMID 24966838. [A1, B5]

Döring Y, Soehnlein O, Weber C (2014). Neutrophils cast NETs in atherosclerosis: employing peptidylarginine deiminase as a therapeutic target. Circ Res. 114:931-4. PMID Döring Y, Soehnlein O, Weber C (2014). Neutrophils cast NETs in atherosclerosis: employing peptidylarginine deiminase as a therapeutic target. Circ Res. 114:931-4. PMID 24625721. [A1, A6, A10, B5]

Duarte Campos DF, Vogt M, Lindner M, Kirsten A, Weber M, Megens RTA, Pyta J, Zenke M, Zandvoort MA, Fischer H (2014). Two-photon laser scanning microscopy as a useful tool for imaging and evaluating macrophage-, IL-4 activated macrophage- and osteoclast-based In vitro degradation of beta-tricalcium phosphate bone substitute material. Microsc Res Tech. 77:143-52. PMID 24282165. [A1, A10, Z1]

Giebeler A, Streetz KL, Soehnlein O, Neumann U, Wang JM, Brandenburg LO (2014). Deficiency of formyl peptide receptor 1 and 2 is associated with increased inflammation and enhanced liver injury after LPS-stimulation. PLoS One. 9:e100522. PMID 24956481. [A6, B5]

Hartmann P, Schober A, Weber C (2014). MicroRNA-155 and macrophages: a fatty liaison. Cardiovasc Res. 103:5-6. PMID 24907979. [A1, A10, B4]

Hartwig H, Drechsler M, Lievens D, Kramp B, von Hundelshausen P, Lutgens E, Weber C, Döring Y, Soehnlein O (2014). Platelet-derived PF4 reduces neutrophil apoptosis following arterial occlusion. Thromb Haemost. 111:562-4. PMID 24258616. [A1, A2, A5, A6, A10, B5]

Heidt T*, Sager HB*, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M (2014). Chronic variable stress activates hematopoietic stem cells. Nat Med. 20:754-758. PMID 24952646; *equal first authors [C1]

Heinrichs D, Berres ML, Coeuru M, Knauel M, Nellen A, Fischer P, Philippeit C, Bucala R, Trautwein C, Wasmuth HE*, Bernhagen J* (2014). Protective role of MIF in nonalcoholic steatohepatitis. FASEB J. 28:5136-5147. PMID 25122558. [A3]

Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Müller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C (2014). MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2. Nat Commun. 5:3970. PMID 24910328. [A1, A10]

Hoeksema MA, Gijbels MJ, van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stöger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJ, Biessen EA, Daemen MJ, Lutgens E, de Winther MP (2014). Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol Med. 6:1124-32. PMID 25007801. [A5]

Jaczewska J, Abdulreda MH, Yau CY, Schmitt MM, Schubert I, Berggren PO, Weber C, Koenen RR, Moy VT, Wojcikiewicz EP (2014). TNF-α and IFN-γ promote lymphocyte adhesion to endothelial junctional regions facilitating transendothelial migration. J Leukoc Biol. 95:265-74. PMID 24072879. [A1, A10]

Kapopara PR, von Felden J, Soehnlein O, Wang Y, Napp LC, Sonnenschein K, Wollert KC, Schieffer B, Gaestel M, Bauersachs J, Bavendiek U (2014). Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodeling and promotes endothelial healing after arterial injury. Thromb Haemost. 112:1264-76. PMID 25120198. [A6, B5]

Keuper M, Jastroch M, Yi CX, Fischer-Posovszky P, Wabitsch M, Tschöp MH, Hofmann SM (2014). Spare mito-chondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic condi-tions. FASEB J. 28:761-70. PMID 24200885. [A4]

Kusters P, Chatzigeorgiou A, Chavakis T, Lutgens E (2014). Immune cell crosstalk in obesity: a key role for costimulation? Diabetes. 63:3982-91. PMID 25414012. [A5]

Kwak BR, Bäck M, Bochaton-Piallat ML, Caligiuri G, Daemen MJ, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ, Evans PC (2014). Biomechanical factors in atherosclerosis: mechanisms and clinical implications. Eur Heart J. 35:3013-3020. PMID 25230814. [A1, A10, B9]

Li X, Zhu M, Penfold ME, Koenen RR, Thiemann A, Heyll K, Akhtar S, Koyadan S, Wu Z, Gremse F, Kiessling F, van Zandvoort M, Schall TJ, Weber C, Schober A (2014). Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue. Circulation. 129:1244-53. PMID 24374972. [A1, A10, B4]

Lutgens E (2014). CD40-CD40L: a Janus-faced interaction. Thromb Haemost. 112:223. PMID 25007918. [A5]

Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Heymann HM, Cher-nogubova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS (2014). miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. Nat Commun. 5:5214. PMID 25358394. [B5]

Mandl M, Schmitz S, Weber C, Hristov M (2014). Characterization of the CD14++CD16+ monocyte population in human bone marrow. PLoS One. 9:e112140. PMID 25369328. [A1, A10]

Merres J, Höss J, Albrecht LJ, Kress E, Soehnlein O, Jansen S, Pufe T, Tauber SC, Brandenburg LO (2014). Role of the cathelicidin-related antimicrobial peptide in inflammation and mortality in a mouse model of bacterial meningitis. J Innate Immun. 6:205-18. PMID 23969854. [A6, B5]

Mion F, D'Incà F, Danelli L, Toffoletto B, Guarnotta C, Frossi B, Burocchi A, Rigoni A, Gerdes N, Lutgens E, Tripodo C, Colombo MP, Rivera J, Vitale G, Pucillo CE (2014). Mast cells control the expansion and differentiation of IL-10-competent B cells. J Immunol. 193:4568-79. PMID 25267976. [A5]

Mohanta SK, Yin C, Peng L, Srikakulapu P, Bontha V, Hu D, Weih F, Weber C, Gerdes N, Habenicht AJR (2014). Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis. Circ Res. 114:1772-87. PMID 24855201. [A1, A10, C2]

Natarelli L, Schober A (2014). Janus-faced role of Krüppel-like factor 2-dependent regulation of microRNAs in endothelial proliferation. Arterioscler Thromb Vasc Biol. 34:1605-6. PMID 25031325. [B4]

Nencioni A, da Silva RF, Fraga-Silva RA, Steffens S, Fabre M, Bauer I, Caffa I, Magnone M, Sociali G, Quercioli A, Pelli G, Lenglet S, Galan K, Burger F, Vázquez Calvo S, Bertolotto M, Bruzzone S, Ballestrero A, Patrone F, Dallegri F, Santos RA, Stergiopulos N, Mach F, Vuilleumier N, Montecucco F (2014). Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice. Thromb Haemost. 111:308-22. PMID 24196571. [B9]

Noels H, Zhou B, Tilstam PV, Theelen W, Li X, Pawig L, Schmitz C, Akhtar S, Simsekyilmaz S, Shagdarsuren E, Schober A, Adams RH, Bernhagen J, Liehn EA, Döring Y, Weber C (2014). Deficiency of endothelial cxcr4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol. 34:1209-1220. PMID 24723559. [A1, A3, A10, B4]

Oldekamp S, Pscheidl S, Kress E, Soehnlein O, Jansen S, Pufe T, Wang JM, Tauber SC, Brandenburg LO (2014). Lack of formyl peptide receptor 1 and 2 leads to more severe inflammation and higher mortality in mice with of pneumococcal meningitis. Immunology. 143:447-61. PMID 24863484. [A6, B5]

Popp T, Steinritz D, Breit A, Deppe J, Egea V, Schmidt A, Gudermann T, Weber C, Ries C (2014). Wnt5a/β-catenin signaling drives calcium-induced differentiation of human primary keratinocytes. J Invest Dermatol. 134:2183-91. PMID 24658506. [A1, A10]

Projahn D, Simsekyilmaz S, Singh S, Kanzler I, Kramp BK, Langer M, Burlacu A, Bernhagen J, Klee D, Zernecke A, Hackeng TM, Groll J, Weber C, Liehn EA, Koenen RR (2014). Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction. J Cell Mol Med. 18:790-800. PMID 24512349. [A1, A3, A10]

Rassaf T, Weber C, Bernhagen J (2014). Macrophage migration inhibitory factor in myocardial ischemia/reperfusion injury. Cardiovasc Res. 102:321-8. PMID 24675723. [A1, A3, A10]

Richter R, Jochheim-Richter A, Kollar K, Ciuculescu F, Seifried E, Forssmann U, Verzijl D, Smit M, Blanchet X, von Hundelshausen P, Weber C, Forssmann WG, Henschler R (2014). Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells. Stem Cells Dev. 23:1959-74. PMID 24708339. [A1, A2, A10]

Ring L, Neth P, Weber C, Steffens S, Faussner A (2014). β-Catenin-dependent pathway activation by both promiscuous "canonical" WNT3a-, and specific "noncanonical" WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency. Cell Signal. 26:260-7. PMID 24269653. [A1, A10, B9]

Rossaint J, Herter JM, Van Aken H, Döring Y, Weber C, Soehnlein O, Zarbock A (2014). Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap mediated sterile inflammation. Blood. 123:2573-84. PMID 24335230. [A1, A6, A10, B5]

Schiener M, Hossann M, Viola JR, Ortega-Gomez A, Weber C, Lauber K, Lindner LH, Soehnlein O (2014). Nanomedicine-based strategies for treatment of atherosclerosis. Trends Mol Med. 20:271-81. PMID 24594264. [A1, A6, A10, B5]

Schmitt MM, Megens RTA, Zernecke A, Bidzhekov K, van den Akker NM, Rademakers T, van Zandvoort MA, Hackeng TM, Koenen RR, Weber C (2014). Endothelial JAM-A guides monocytes into flow-dependent predilection sites of atherosclerosis. Circulation. 129:66-76. PMID 24065611. [A1, A10, Z1]

Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RTA, Heyll K, Noels H, Hristov M, Wang S, Kiessling F, Olson EN, Weber C (2014). MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 20:368-76. PMID 24584117. [A1, A10, B4, Z1]

Seijkens T, Hoeksema MA, Beckers L, Smeets E, Meiler S, Levels J, Tjwa M, de Winther MP, Lutgens E (2014). Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis. FASEB J. 28:2202-13. PMID 24481967. [A5]

Seijkens T, Kusters P, Chatzigeorgiou A, Chavakis T, Lutgens E. Immune cell crosstalk in obesity: a key role for costimulation? Diabetes. 63:3982-91. PMID 25414012. [A5]

Silvestre-Roig C, de Winther MP, Weber C, Daemen MJ, Lutgens E, Soehnlein O (2014). Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies. Circ Res. 114:214-226. PMID 24385514. [A1, A5, A6, A10, B5]

Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A (2014). The role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation. 129:598-606. PMID 24201302. [A1, A10]

Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A (2014). Response to letter regarding article "Role of extracellular RNA in atherosclerotic plaque formation in mice". Circulation. 130:e144-5. PMID 25311624. [A1, A10]

Soehnlein O (2014). Macrophages shine bright. Blood. 124:2320-2. PMID 25301333. [A6, B5]

Soehnlein O (2014). The ABC of thrombopoiesis. Arterioscler Thromb Vasc Biol. 34:700-1. PMID 24665122. [A6, B5]

Steffens S (2014). Fine tuning effector and regulatory T-cell dynamics: a novel tool for plaque regression? Cardiovasc Res. 102:3-5. PMID 24556952. [B9]

Tilstam PV, Gijbels MJ, Habbeddine M, Cudejko C, Asare Y, Theelen W, Zhou B, Döring Y, Drechsler M, Pawig L, Simsekyilmaz S, Koenen RR, de Winther MP, Lawrence T, Bernhagen J, Zernecke A, Weber C, Noels H (2014). Bone marrow-specific knock-in of a non-activatable ikkα kinase mutant influences haematopoiesis but not atherosclerosis in apoe-deficient mice. PLoS One. 9:e87452. PMID 24498325. [A1, A3, A10, B3]

Vijayan S*, Asare Y*, Grommes J, Soehnlein O, Lutgens E, Shagdarsuren G, Togtokh A, Jacobs MJ, Fischer JW, Bernhagen J, Weber C, Schober A, Shagdarsuren E (2014). High expression of C5L2 correlates with high proin-flammatory cytokine expression in advanced human atherosclerotic plaques. Am J Pathol. 184:2123-33. PMID 24819959 *shared first authors [A1, A3, A5, A6, A10, B3, B4, B5]

Von Hundelshausen P, Schmitt MM (2014). Platelets and their chemokines in atherosclerosis-clinical applications. Front Physiol. 5:294. PMID 25152735. [A2]

Wan M, Soehnlein O, Tang X, van der Does AM, Smedler E, Uhlén P, Lindbom L, Agerberth B, Haeggström JZ (2014). Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo. FASEB J. 28:3456-67. PMID 24736410. [A6, B5]

Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I (2014). Rubbing salt into wounded endothelium: Sodium potentiates proatherogenic effects of TNF-α under non-uniform shear stress. Thromb Haemost. 112:183-95. PMID 24573382. [A6, B5]

Wildhagen KC, García de Frutos P, Reutelingsperger CP, Schrijver R, Aresté C, Ortega-Gómez A, Deckers NM, Hemker HC, Soehnlein O, Nicolaes GA (2014). Non-anticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood. 123:1098-101. PMID 24264231. [A6, B5]

Wildhagen KC, Schrijver R, Beckers L, Ten Cate H, Reutelingsperger CP, Lutgens E, Nicolaes GA (2014). Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis. PLoS One. 9:e101446. PMID 25032959.

Winkels H, Weber C, Lutgens E, Gerdes N (2014). Atherosclerosis: cell biology and lipoproteins focus on iNKT cells and CD40/CD40L in atherosclerosis and metabolic disorders. Curr Opin Lipidol. 25:408-9. PMID 25186203. [A1, A5, A10]

Zernecke A, Weber C (2014). Chemokines in atherosclerosis: proceedings resumed. Arterioscler Thromb Vasc Biol. 34:742-50. PMID 24436368. [A1, A10]