Publications 2017

Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E (2017). Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. J Neuroinflam. 14:105-110. PMID 28494768. [A1, A5, A10]

Aarts SABM, Seijkens TTP, van Dorst KJF, Dijkstra CD, Kooij G, Lutgens E (2017). The CD40-CD40L dyad in experimental autoimmune encephalomyelitis and multiple sclerosis. Front Immunol. 8:1791. PMID 29312317. [A5]

Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Janowski J, Pardi R, de Winther MPJ, Noels H*, Bernhagen J* (2017). Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A. 114:E2766-E2775. PMID 2829289. [A1, A3, A10, B3]

Atzler D, McAndrew DJ, Cordts K, Schneider JE, Zervou S, Schwedhelm E, Neubauer S, Lygate CA (2017). Dietary supplementation with homoarginine preserves cardiac function in a murine model of post-myocardial infarction heart failure. Circulation. 135:400-402. PMID 28115416. [A5]

Bartelt A*#, John C*, Schaltenberg N*, Berbée JFP*, Worthmann A*, Cherradi ML, Schlein C, Piepenburg J, Boon MR, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson SK, Fischer M, Wijers SL, van Marken Lichtenbelt W, Scheja L, Rensen PCN, Rensen PC*#, Heeren J* (2017). Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport. Nat Commun. 8:15010. PMID 28422089 *shared first authors, #shared corresponding authors [B10]

Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T (2017). CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. Nat Commun. 8:14715. PMID 28276457. [A5]

Beldman TJ, Senders ML, Alaarg A, Pérez-Medina C, Tang J, Zhao Y, Fay F, Deichmöller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E (2017). Hyaluronan nanoparticles selectively target plaque-associated macrophages and improve plaque stability in atherosclerosis. ACS Nano. 11:5785-5799. PMID 28463501. [A5]

Brænne I, Willenborg C, Tragante V, Kessler T, Zeng L, Reiz B, Kleinecke M, von Ameln S, Willer C, Laakso M, Wild P, Zeller T, Wallentin L, Franks P, Salomaa V, Dehghan A, Meitinger T, Samani N, Asselbergs F, Erdmann J, Schunkert H (2017). A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors. Sci Rep. 7:10252. PMID 28860667. [B2]

Brænne I, Zeng L, Willenborg C, Tragante V, Kessler T, CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium, Willer CJ, Laakso M, Wallentin L, Franks PW, Salomaa V, Dehghan A, Meitinger T, Samani NJ, Asselbergs FW, Erdmann J, Schunkert H (2017). Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk. PLoS One. 12:e0182999. PMID 28829817. [B2]

Bruns OT*, Bischof TS*, Harris DK, Franke D, Shi Y, Riedemann L, Bartelt A, Jaworski FB, Carr JA, Rowlands CJ, Wilson MWB, Chen O, Hwang GW, Montana DM, Coropceanu I, Achorn OB, Kloepper J, Heeren J, So PTC, Fukumura D, Jensen KF, Jain RK, Bawendi MG. (2017). Next-generation in vivo optical imaging with short-wave infrared quantum dots. Nat Biomed Eng. 1:0056. PMID 29119058. [B10]

Cheng HS, Besla R, Li A, Chen Z, Shikatani EA, Nazari-Jahantigh M, Hammoutène A, Nguyen MA, Geoffrion M, Cai L, Khyzha N, Li T, MacParland SA, Husain M, Cybulsky MI, Boulanger CM, Temel RE, Schober A, Rayner KJ, Robbins CS, Fish JE (2017). Paradoxical suppression of atherosclerosis in the absence of microRNA-146a. Circ Res. 121:354-367. PMID 28637783. [B4]

Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D (2017). Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes. Eur Heart J. 38:292-301. PMID 28182242. [C3]

Clemmensen C, Müller TD, Woods SC, Berthoud HR, Seeley RJ, Tschöp MH (2017). Gut-brain cross-talk in metabolic control. Cell. 168:758-774. PMID 28235194. [A4]

De Jong RJ, Leoni G, Drechsler M, Soehnlein O (2017). The advantageous role of annexin A1 in cardiovascular disease. Cell Adh Migr. 11:261-274. PMID 27860536. [A6, B5]

De Jong RJ, Paulin N, Lemnitzer P, Viola JR, Winter C, Ferraro B, Grommes J, Weber C, Reutelingsperger C, Drechsler M, Soehnlein O (2017). Protective aptitude of annexin A1 in arterial neointima formation in atherosclerosis-prone mice-brief report. Arterioscler Thromb Vasc Biol. 37:312-315. PMID 28062503. [A1, A6, A10, B5]

Dichgans M, Leys D (2017). Vascular cognitive impairment. Circ Res. 120:573-591. PMID 28154105. [B3]

Ding L, Deán-Ben XL, BurtonNC, Sobol RW, Ntziachristos V, Razansky D (2017). Constrained inversion and spectral unmixing in multispectral optoacoustic tomography. IEEE Transactions on Medical Imaging. 36:1676-1685. PMID 28333622. [Z1]

Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C (2017). Vascular CXCR4 limits atherosclerosis by maintaining arterial integrity: evidence from mouse and human studies. Circulation. 136:388-403. PMID 28450349. [A1, A5, A6, A10, B1, B5, Z1]

Döring Y, Soehnlein O, Weber C (2017). Neutrophil extracellular traps in atherosclerosis and atherothrombosis. Circ Res. 120:736-743. PMID 28209798. [A1, A6, A10, B5]

Duchêne J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K, Caamaño J, Rülicke T, Moss P, Megens RTA, von Andrian UH, Hidalgo A, Weber C, Rot A (2017). Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. Nat Immunol. 18:753-761. PMID 28553950. #corresponding authors. [A1, A10, Z1]

Eken SM, Jin H, Chernogubova E, Li Y, Simon N, Sun C, Korzunowicz G, Busch A, Bäcklund A, Österholm C, Razuvaev A, Renné T, Eckstein HH, Pelisek J, Eriksson P, González Díez M, Perisic Matic L, Schellinger IN, Raaz U, Leeper NJ, Hansson GK, Paulsson-Berne G, Hedin U, Maegdefessel L (2017). MicroRNA-210 enhances fibrous cap stability in advanced atherosclerotic lesions. Circ Res. 120:633-644. PMID 27895035. [B5]

Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S, Thompson AAR, Jo H, Weber C, Ridger V, Schober A, Evans PC (2017). Mechanical activation of hypoxia-inducible factor 1α drives endothelial dysfunction at atheroprone sites. Arterioscler Thromb Vasc Biol. 37:2087-2101. PMID 28882872. [A1, A10, B4]

Ferrari E, Lutgens E, Weber C, Gerdes N (2017). Atherosclerosis: cell biology and lipoproteins focus on epigenetic modification and macrophage biology. Curr Opin Lipidol. 28:220-221. PMID 28272157. [A1, A5, A10]

Fischer K, Ruiz HH, Jhun K, Finan B, Oberlin DJ, van der Heide V, Kalinovich AV, Petrovic N, Wolf Y, Clemmensen C, Shin AC, Divanovic S, Brombacher F, Glasmacher E, Keipert S, Jastroch M, Nagler J, Schramm KW, Medrikova D, Collden G, Woods SC, Herzig S, Homann D, Jung S, Nedergaard J, Cannon B, Tschöp MH, Müller TD, Buettner C (2017). Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nat Med. 23:623-630. PMID 28414329. [A4, B9]

Frias JP, Bastyr EJ, Vignati L, Tschöp MH, Schmitt C, Owen K, Christensen RH, DiMarchi R (2017). The sustained effects of a dual GIP/GLP-1 receptor agonist, NNC0090-2746, in patients with type 2 diabetes. Cell Metab. 26:343-352. PMID 28768173. [A4]

Gaertner F, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt M, Massberg S (2017). Migrating platelets are mechano-scavengers that collect and bundle bacteria. Cell. 171:1368-1382. PMID 29195076. [B6]

Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, Buijs RM, Woods SC, Kalsbeek A, Seeley RJ, Nawroth PP, Bidlingmaier M, Tschöp MH, Yi CX (2017). Dietary sugars, not lipids, drive hypothalamic inflammation. Mol Metab. 6:897-908. PMID 28752053. [A4]

Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J (2017). Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Oncotarget. 8:35542-35557. PMID 28415767. [A5]

Hakimzadeh N, Pinas VA, Molenaar G, de Waard V, Lutgens E, van Eck-Smit BLF, de Bruin K, Piek JJ, Eersels JLH, Booij J, Verberne HJ, Windhorst AD (2017). Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques. PLoS One. 12:e0187767. PMID 29190653. [A5]

Horckmans M, Ring L, Duchêne J, Santovito D, Schloss MJ, Drechsler M, Weber C, Soehnlein O, Steffens S (2017). Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype. Eur Heart J. 38:187-197. PMID 28158426. [A1, A6, A10, B5]

Hyafil F, Pelisek J, Laitinen I, Schottelius M, Mohring M, Döring Y, Van der Vorst EPC, Kallmayer M, Steiger K, Poschenrieder A, Notni J, Fischer J, Baumgartner C, Rischpler C, Nekolla S, Weber C, Eckstein HH, Wester HJ, Schwaiger M (2017). Imaging the cytokine receptor CXCR4 in atherosclerotic plaques with the radiotracer 68Ga-pentixafor for positron emission tomography. J Nucl Med. 58:499-506. PMID 27789718. [A1, A10, C2]

Jall S, Sachs S, Clemmensen C, Finan B, Neff F, DiMarchi RD, Tschöp MH, Müller TD, Hofmann SM (2017). Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice. Mol Metab. 6:440-446. PMID 28462078. [A4]

Jung C, Lichtenauer M, Strodthoff D, Winkels H, Wernly C, Bürger C, Kamchybekov U, Lutgens E, Figulla HR, Gerdes N (2017). Alterations in systemic levels of Th1, Th2 and Th17 cytokines in overweight adolescents and obese mice. Pediatr Diabetes. 18:714-721. PMID 27597513. [A5]

Karlas A, Reber J, Diot G, Bozhko D, Anastasopoulou M, Ibrahim T, Schwaiger M, Hyafil F, Ntziachristos V (2017). Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept. Biomed. Opt. Express. 8:3395-3403. PMID 28717575. [Z1]

Kessler T, Wobst J, Wolf B, Eckhold J, Vilne B, Hollstein R, von Ameln S, Dang TA, Sager HB, Moritz Rumpf P, Aherrahrou R, Kastrati A, Björkegren JLM, Erdmann J, Lusis AJ, Civelek M, Kaiser FJ, Schunkert H (2017). Functional characterization of the GUCY1A3 coronary artery disease risk locus. Circulation. 136:476-489. PMID 28487391. [B2, C1]

Keuper M, Sachs S, Walheim E, Berti L, Raedle B, Tews D, Fischer-Posovszky P, Wabitsch M, Hrabě de Angelis M, Kastenmüller G, Tschöp MH, Jastroch M, Staiger H, Hofmann SM (2017). Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors. Mol Metab. 6:1226-1239. PMID 29031722. [A4]

Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S (2017). Myocardial Infarction Genetics Consortium, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium (2017). Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease. JAMA. 317:937-946. PMID 28267856. [B2]

Kim BS, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R (2017). D-dopachrome tautomerase in adipose tissue inflammation and wound repair. J Cell Mol Med. 21:35-45. PMID 27605340. [A3]

Kleinert M, Clemmensen C, Stemmer K, Müller TD, DiMarchi RD, Tschöp MH (2017). Emerging poly-agonists for obesity and type 2 diabetes. Obesity. 25:1647-1649. PMID 28948717. [A4]

Krishnasamy K, Limbourg A, Kapanadze T, Gamrekelashvili J, Beger C, Häger C, Lozanovski VJ, Falk CS, Napp LC, Bauersachs J, Mack M, Haller H, Weber C, Adams RH, Limbourg FP (2017). Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia. Nat Commun. 8:952. PMID 29038527. [A1, A10]

Kusters P, Seijkens T, Bürger C, Legein B, Winkels H, Gijbels M, Barthels C, Bennett R, Beckers L, Atzler D, Biessen E, Brocker T, Weber C, Gerdes N, Lutgens E (2017). Constititive CD40 signaling in dendritic cells limits atherosclerosis by provoking inflammatory bowel disease and ensuing cholesterol malabsorption. Am J Pathol. 187:2912-2919. PMID 28935569. [A1, A5, A10]

Lip GYH, Weber C (2017). Thrombosis and Haemostasis: past, present and future. Thromb Haemost. 117:1217-1218. PMID 30457155. [A1, A10]

Lip GY, Weber C (2017). A happy and prosperous New Year 2017 with "Thrombosis and Haemostasis" …. and our 60th Anniversary! Thromb Haemost. 117:1-2. PMID 28066853. [A1, A10]

Llovera G, Benakis C, Enzmann G, Cai R, Arzberger T, Ghasemigharagoz A, Mao X, Malik R, Lazarevic I, Liebscher S, Ertürk A, Meissner L, Vivien D, Haffner C, Plesnila N, Montaner J, Engelhardt B, Liesz A (2017). The choroid plexus is a key cerebral invasion route for T-cells after stroke. Acta Neuropathol. 134:851-868. PMID 28762187. [C1]

Lubitz SA, Parsons OE, Anderson CD, Benjamin EJ, Malik R, Weng LC, Dichgans M, Sudlow CL, Rothwell PM, Rosand J, Ellinor PT, Markus HS, Traylor M; WTCCC2, International Stroke Genetics Consortium, and AFGen Consortia (2017). Atrial fibrillation genetic risk and ischemic stroke mechanisms. Stroke. 48:1451-1456. PMID 28468926. [B3]

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH (2017). The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 23:631-637. PMID 28346411. [B10]

Maffia P, Döring Y, Biessen EA, Mallat Z (2017). Commentary: indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory T cells. Front Immunol. 8:140. PMID 28243244. [A1]

Malekzadeh-Najafabadi J, Prakash J, Ntziachristos V (2017). Nonlinear optoacoustic readings from diffusive media at near-infrared wavelengths. J. Biophotonics. e201600310. PMID 28787111. [Z1]

Malik R, Dau T, Gonik M, Sivakumar A, Deredge DJ, Edeleva EV, Götzfried J, van der Laan SW, Pasterkamp G, Beaufort N, Seixas S, Bevan S, Lincz LF, Holliday EG, Burgess AI, Rannikmäe K, Minnerup J, Kriebel J, Waldenberger M, Müller-Nurasyid M, Lichtner P, Saleheen D; International Stroke Genetics Consortium, Rothwell PM, Levi C, Attia J, Sudlow CL, Braun D, Markus HS, Wintrode PL, Berger K, Jenne DE, Dichgans M (2017). A common coding variant in SERPINA1 increases the risk for large artery stroke. Proc Natl Acad Sci U S A. 114:3613-3618. PMID 28265093. [B3]

Mojica Muñoz AK, Jamasbi J, Uhland K, Degen H, Münch G, Ungerer M, Brandl R, Megens RTA, Weber C, Lorenz R, Siess W (2017). Recombinant GPVI-Fc added to single or dual antiplatelet therapy in vitro prevents plaque-induced platelet thrombus formation. Thromb Haemost. 117:1651-1659. PMID 28569920. [A1, A10, Z1]

Neele AE, Prange KH, Hoeksema MA, van der Velden S, Lucas T, Dimmeler S, Lutgens E, Van den Bossche J, de Winther MP (2017). Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells. Epigenomics. 9:383-391. PMID 28322580. [A5]

Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I, Lai FY, Hopewell JC, Gian-nakopoulou O, Jiang T, Hamby SE, Di Angelantonio E, Assimes TL, Bottinger EP, Chambers JC, Clarke R, Palmer CNA, Cubbon RM, Ellinor P, Ermel R, Evangelou E, Franks PW, Grace C, Gu D, Hingorani AD, Howson JMM, Ingelsson E, Kastrati A, Kessler T, Kyriakou T, Lehtimäki T, Lu X, Lu Y, März W, McPherson R, Metspalu A, Pujades-Rodriguez M, Ruusalepp A, Schadt EE, Schmidt AF, Sweeting MJ, Zalloua PA, AlGhalayini K, Keavney BD, Kooner JS, Loos RJF, Patel RS, Rutter MK, Tomaszewski M, Tzoulaki I, Zeggini E, Erdmann J, Dedoussis G, Björkegren JLM; EPIC-CVD Consortium; CARDIoGRAMplusC4D; UK Biobank CardioMetabolic Consortium CHD working group, Schunkert H, Farrall M, Danesh J, Samani NJ, Watkins H, Deloukas P (2017). Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nat Genet. 49:1385-1391. PMID 28714975. [B2]

Nicolaou A, Zhao Z, Northoff BH, Sass K, Herbst A, Kohlmaier A, Chalaris A, Wolfrum C, Weber C, Steffens S, Rose-John S, Teupser D, Holdt LM (2017). Adam17 deficiency promotes atherosclerosis by enhanced TNFR2 signaling in mice. Arterioscler Thromb Vasc Biol. 37:247-257. PMID 28062509. [A1, A10, B1, B9]

Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini P, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JM, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri M, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh JN, Ardissino D, Gabriel SB, Willer CJ, Abecasis G, Saleheen D, Kubo M, Kato N, YI Chen, Dewey F, Kathiresan S (2017). Protein truncating variants at the cholesteryl ester transfer protein gene and risk for coronary heart disease. Circ Res. 121:81-88. PMID 28506971. [B2]

Paulin N, Döring Y, Kooijman S, Blanchet X, Viola JR, de Jong R, Mandl M, Hendrikse J, Schiener M, von Hundelshausen P, Vogt A, Weber C, Bdeir K, Hofmann SM, Rensen PC, Drechsler M, Soehnlein O (2017). Human neutrophil peptide 1 limits hypercholesterolemia-induced atherosclerosis by increasing hepatic LDL clearance. EBioMedicine. 16:204-211. PMID 28111237. [A1, A2, A4, A6, A10, B5]

Pfeiler S, Stark K, Massberg S, Engelmann B (2017). Propagation of thrombosis by neutrophils and extracellular nucleosome networks. Haematologica. 102:206-213. PMID 27927771. [A7, B6]

Phuah CL, Dave T, Malik R, Raffeld MR, Ayres AM, Goldstein JN, Viswanathan A, Greenberg SM, Jagiella JM, Hansen BM, Norrving B, Jimenez-Conde J, Roquer J, Pichler A, Enzinger C, Montaner J, Fernandez-Cadenas I, Lindgren A, Slowik A, Schmidt R, Biffi A, Rost N, Langefeld CD, Markus HS, Mitchell BD, Worrall BB, Kittner SJ, Woo D, Dichgans M, Rosand J, Anderson CD; METASTROKE; NINDS-SiGN Consortium; International Stroke Genetics Consortium (2017). Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke. Brain. 140:2663-2672. PMID 28969386. [B3]

Pick R, Begandt D, Stocker TJ, Salvermoser M, Thome S, Böttcher RT, Montanez E, Harrison U, Forné I, Khandoga AG, Coletti R, Weckbach LT, Brechtefeld D, Haas R, Imhof A, Massberg S, Sperandio M, Walzog B (2017). Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity. Blood. 130:847-858. PMID 28615221. [B6, Z2]

Quarta C, Clemmensen C, Zhu Z, Joseph S, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Yang B, Vettorazzi S, Hofmann SM, Bakhti M, Ponce MB, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Tuckermann J, Hrabe de Angelis M, Cota D, Latz E, Sandoval D, Müller TD, Yang B, DiMarchi R, Finan F, Tschöp MH (2017). Molecular integration of incretin and glucocorticoid action reverses immunometabolic dysfunction and obesity. Cell Metab. 26:620-632.e6. PMID 28943448. [A4, B7]

Rademakers T, van der Vorst EPC, Daissormont IT, Otten JJ, Theodorou K, TheelenTL, Gijbels M, Anisimov A, Nurmi H, Lindeman JH, Schober A, Heeneman S, Alitalo K, Biessen EA (2017). Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis. Sci Rep. 7:45263. PMID 28349940. [B4, C2]

Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM; Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC) (2017). COL4A2 is associated with lacunar ischemic stroke and deep ICH: meta-analyses among 21,500 cases and 40,600 controls. Neurology. 89:1829-1839. PMID 28954878. [B3]

Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat ML, Boilard E, Buzas EI, Caporali A, Dignat-George F, Evans PC, Lacroix R, Lutgens E, Ketelhuth DFJ, Nieuwland R, Toti F, Tunon J, Weber C, Hoefer IE (2017). Microvesicles in vascular homeostasis and diseases. Position paper of the European society of cardiology (ESC) working group on atherosclerosis and vascular biology. Thromb. Haemost. 117: 1296-1316. PMID 28569921. [A5, A1, A10]

Rowinska Z, Koeppel TA, Sanati M, Schelzig H, Jankowski J, Weber C, Zernecke A, Liehn EA (2017). Role of the CX3C chemokine receptor CX3CR1 in the pathogenesis of atherosclerosis after aortic transplantation. PLoS One. e:0170644. PMID 28234900. [A1, A10]

Saleheen D, Zhao W, Young R, Nelson CP, Ho W, Ferguson J, Rasheed A, Ou K, Nurnberg ST, Bauer RC, Goel A, Do R, Stewart AFR, Hartiala J, Zhang W, Thorleifsson G, Strawbridge RJ, Sinisalo J, Kanoni S, Sedaghat S, Marouli E, Kristiansson K, Hua J, Scott R, Gauguier D, Shah S, Smith AV, van Zuydam NR, Cox AJ, Willenborg C, Kessler T, Zeng L, Province MA, Ganna A, Lind L, Pedersen NL, White CC, Joensuu A, Kleber ME, Hall AS, März W, Salomaa V, O'Donnell C, Ingelsson E, Feitosa MF, Erdmann J, Bowden DW, Palmer CN, Gudnason V, De Faire U, Zalloua P, Wareham N, Thompson JR, Kuulasmaa K, Dedoussis G, Perola M, Dehghan A, Chambers JC, Kooner J, Allayee H, Deloukas P, McPherson R, Stefansson K, Schunkert H, Kathiresan S, Farrall M, EPIC-CVD, Frossard P, Rader DJ, Samani NJ, PROMIS, CARDIoGRAMplusC4D, Reilly MP (2017). Loss of cardio-protective effects at the ADAMTS7 locus due to gene-smoking interactions. Circulation. 135:2336-2353. PMID 28461624. [B2]

Santovito D, Weber C (201). Atherosclerosis revisited from a clinical perspective: still an inflammatory disease? Thromb Haemost. 17:231-237. PMID 27975102. [A1, A10]

Schinner C, Vielmuth F, Rötzer V, Hiermaier M, Radeva MY, Co TK, Hartlieb E, Schmidt A, Imhof A, Messoudi A, Horn A, Schlipp A, Spindler V, Waschke J (2017). Adrenergic signaling strengthens cardiac myocyte cohesion. Circ Res. 120:1305-1317. PMID 28289018. [Z2]

Schloss MJ, Hilby M, Nitz K, Guillamat Prats R, Ferraro B, Leoni G, Soehnlein O, Kessler T, He W, Luckow B, Horckmans M, Weber C, Dûchene J, Steffens S (2017). Ly6Chigh monocytes oscillate in the heart during homeostasis and after myocardial infarction-brief report. Arterioscler Thromb Vasc Biol. 37:1640-1645. PMID 28663258. [A1, A6, A10, B2, B5]

Sibbing D, Aradi D, Jacobshagen C, Gross L, Trenk D, Geisler T, Orban M, Hadamitzky M, Merkely B, Kiss RG, Komócsi A, Dézsi CA, Holdt LM, Felix SB, Parma R, Klopotowski M, Schwinger RHG, Rieber J, Huber K, Neumann FJ, Koltowski L, Mehilli J, Huczek Z, Massberg S; TROPICAL-ACS investigators (2017). Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial. Lancet. 390:1747-1757. PMID 28855078. [B6]

Soehnlein O, Silvestre-Roig C (2017) .Basic research: standardizing animal atherosclerosis studies to improve reproducibility. Nat Rev Cardiol. 14:574-575. PMID 28880022. [A6, B5]

Soehnlein O, Steffens S, Hidalgo A, Weber C (2017). Neutrophils as protagonists and targets in chronic inflammation. Nat Rev Immunol. 17:248-261. PMID 28287106. [A1, A6, A10, B5, B9]

Steffens S, Winter C, Schloss MJ, Hidalgo A, Weber C, Soehnlein O (2017). Circadian control of inflammatory processes in atherosclerosis and its complications. Arterioscler Thromb Vasc Biol. 37:1022-1028. PMID 28450299. [A1, A6, A10, B5, B9]

Stutz A, Kolbe CC, Stahl R, Horvath GL, Franklin BS, van Ray O, Brinkschulte R, Geyer M, Meissner F, Latz E (2017). NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. J Exp Med. 214:1725-1736. PMID 28465465. [B7]

Theodorou K, van der Vorst EPC, Gijbels MJ, Wolfs IMJ, Jeurissen M, Theelen TL, Sluimer JC, Wijnands E, Cleutjens JP, Li Y, Jansen Y, Weber C, Ludwig A, Bentzon JF, Bartsch JW, Biessen EAL, Donners MMPC (2017). Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression. Sci Rep. 7:11670. PMID 28916789. [A1, A10, C2]

Tiedt S, Prestel M, Kautzky V, Duering M, Northoff B, Malik R, Klein M, Dorn F, Krohn K, Teupser D, Holdt LM, Dichgans M (2017). RNA-seq identifies circulating miR-125a-5p, miR-125b-5p and miR-143-3p as potential biomarkers for acute ischemic stroke. Circ Res. 121:970-980. PMID 28724745. [B1, B3]

Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, Chauhan G, Debette S, Bis JC, Longstreth WT Jr, Ikram MA, Launer LJ, Seshadri S; METASTROKE, UK Young Lacunar DNA Study, NINDS Stroke Genetics Network, Neurology Working Group of the CHARGE Consortium, Hamilton-Bruce MA, Jimenez-Conde J, Cole JW, Schmidt R, Słowik A, Lemmens R, Lindgren A, Melander O, Grewal RP, Sacco RL, Rundek T, Rexrode K, Arnett DK, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Pulit SL, Wong Q, Rich SS, de Bakker PI, McArdle PF, Woo D, Anderson CD, Xu H, Heitsch L, Fornage M, Jern C, Stefansson K, Thorsteinsdottir U, Gretarsdottir S, Lewis CM, Sharma P, Sudlow CL, Rothwell PM, Boncoraglio GB, Thijs V, Levi C, Meschia JF, Rosand J, Kittner SJ, Mitchell BD, Dichgans M, Worrall BB, Markus HS, on behalf of the International Stroke Genetics Consortium (2017). Genetic variation at 16q24.2 is associated with small vessel stroke. Ann Neurol. 81:383-394. [B3]

Tufanli[GC1] O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Çimen I, Walter P, Weber C, Erbay E (2017). Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 114:E1395-E1404. PMID 28137856. [A1, A10]

Tzoumas S, Ntziachristos V (2017). Spectral unmixing techniques for optoacoustic imaging of tissue pathophysiology. Philos Trans A Math Phys Eng Sci. 375:20170262. PMID 29038385. [Z1]

Van den Berg SM, van Dam AD, Kusters PJ, Beckers L, den Toom M, van der Velden S, Van den Bossche J, van Die I, Boon MR, Rensen PCN, Lutgens E, de Winther MP (2017). Helminth antigens counteract a rapid high-fat diet induced decrease in adipose tissue eosinophils. J Mol Endocrinol. 59:245-255. PMID 28694301. [A5]

Van den Berg SM, van Dam AD, Rensen PCN, de Winther M, Lutgens E (2017). Immune modulation of and by brown(ing) adipose tissue in obesity. Endocrine reviews. 17:46-68. PMID 27849358. [A5]

Van der Vorst EPC, Zhao Z, Rami M, Holdt LM, Teupser D, Steffens S, Weber C (2017). Contrasting effects of myeloid and endothelial ADAM17 on atherosclerosis development. Thromb Haemost. 117:644-646. PMID 28004058. [A1, A10, B1, B9, C2]

Van der Vorst EPC, Maas SL, Ortega-Gomez A, Hameleers JMM, Bianchini M, Asare Y, Soehnlein O, Döring Y, Weber C, Megens RTA (2017). Functional ex-vivo imaging of arterial cellular recruitment and lipid extravasation. Bio Protoc. 7:e2344. PMID 28890907. [A1, A6, A10, B3, B5, Z1]

Van der Vorst EPC, Theodorou K, Biessen EAL, Donners MMPC (2017). HDL and macrophages: explaining the clinical failures and advancing HDL-based therapeutics in cardiovascular diseases? Expert Rev Cardiovasc Ther. 15:343-344. PMID 28349717. [C2]

Van der Vorst EP, Theodorou K, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LF, Tas SW, Wolfs IM, Kuijpers MJ, Gijbels MJ, Schalkwijk CG, Koonen DP, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, de Winther MP, Biessen EA, Donners MM (2017). High-density lipoproteins exert pro-inflammatory effects on macrophages via passive cholesterol depletion and PKC-NF-κB/STAT1-IRF1 signaling. Cell Metab. 25:197-207. PMID 27866837. [C2]

Varasteh[GC1] Z, Hyafil F, Anizan N, Diallo D, Aid-Launais R, Mohanta S, Li Y, Braeuer M, Steiger K, Vigne J, Qin Z, Nekolla SG, Fabre JE, Döring Y, Le Guludec D, Habenicht A, Vera DR, Schwaiger M (2017). Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 111In-tilmanocept. EJNMMI Res. 7:40. PMID 28470406. [A1]

Varela L, Suyama S, Huang Y, Shanabrough M, Tschöp MH, Gao XB, Giordano FJ, Horvath TL (2017). Endothelial HIF-1α enables hypothalamic glucose uptake to drive POMC neurons. Diabetes. 66:1511-1520. PMID 28292966. [A4]

Vilne B, Skogsberg J, Foroughi Asl H, Talukdar HA, Kessler T, Björkegren JLM, Schunkert H (2017). Network analysis reveals a causal role of mitochondrial gene activity in atherosclerotic lesion formation. Atherosclerosis. 267:39-48. PMID 29100060. [B2]

Von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RTA, Naumann R, Dijkgraaf I, Nicolaes GA, Döring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C (2017). Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Sci Transl Med. 9:eaah6650. PMID 28381538. [A1, A2, A5, A6, A10, B5, Z1]

Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, Franzén O, Schadt EE, Björkegren JL, Weeke PE, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kruppa J, Mahajan A, Scott RA, Willenborg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer C, El-Mokhtari NE, Franke A, Heilmann S, Hengstenberg C, Hoffmann P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Virtamo J, Nikpay M, Olivieri O, Provost S, AlQarawi A, Robertson NR, Akinsansya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Müller-Nurasyid M, Strauch K, Varga TV, Waldenberger M; Wellcome Trust Case Control Consortium, Zeng L, Chowdhury R, Salomaa V, Ford I, Jukema JW, Amouyel P, Kontto J; MORGAM Investigators, Nordestgaard BG, Ferrières J, Saleheen D, Sattar N, Surendran P, Wagner A, Young R, Howson JM, Butterworth AS, Danesh J, Ardissino D, Bottinger EP, Erbel R, Franks PW, Girelli D, Hall AS, Hovingh GK, Kastrati A, Lieb W, Meitinger T, Kraus WE, Shah SH, McPherson R, Orho-Melander M, Melander O, Metspalu A, Palmer CN, Peters A, Rader DJ, Reilly MP, Loos RJ, Reiner AP, Roden DM, Tardif JC, Thompson JR, Wareham NJ, Watkins H, Willer CJ, Samani NJ*, Schunkert H*, Deloukas P*, Kathiresan S*; Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators (2017). Systematic evaluation of pleiotropy identifies six further loci associated with coronary artery disease. J Am Coll Cardiol. 69:823-836. PMID 28209224. [B2]

Weber C, von Hundelshausen P (2017). CANTOS trial validates the inflammatory pathogenesis of atheroscle-rosis: setting the stage for a new chapter in therapeutic targeting. Circ Res. 121:1119-21. PMID 29074528. [A1, A2, A10]

Weber C, Badimon L, Mach F, van der Vorst EPC. Therapeutic strategies for atherosclerosis and atherothrombosis: past, present and future. Thromb Haemost. 117:9. PMID 28594053. [A1, A10, C2]

Weber C, Lip GY (2017). Editors' Choice 2016 papers in Thrombosis and Haemostasis. Thromb Haemost. 117:204-206. PMID 28066852. [A1, A10]

Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS (2017). NRF1 is an ER membrane sensor that is central to cholesterol homeostasis. Cell. 171:1094-1109 e1015. PMID 29149604. [B10]

Winkels H, Meiler S, Lievens D, Engel D, Spitz C, Bürger C, Beckers L, Dandl A, Reim S, Ahmadsei M, Hartwig H, Holdt LM, Hristov M, Megens RTA, Schmitt MM, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E*, Gerdes N* (2017). CD27 co-stimulation increases the abundance of regulatory T-cells and reduces atherosclerosis in hyperlipidaemic mice. Eur Heart J. 38:3590-3599. PMID 29045618 *shared corresponding authors [A5, A1, A10, Z1]

Winkels H, Meiler S, Smeets E, Lievens D, Engel E, Spitz C, Bürger C, Rinne P, Beckers L, Dandl A, Reim S, Ahmadsei M, Van den Bossche J, Holdt LM, Megens RTA, Schmitt MM, de Winther M, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E*, Gerdes N* (2017). CD70 limits atherosclerosis and promotes macrophage function. Thromb Haemost. 117:164-175. PMID 27786334. [A1, A5, A10, B1, Z1]

Wolf D, Bukosza N, Engel D, Poggi M, Jehle F, Anto Michel N, Chen YC, Colberg C, Hoppe N, Dufner B, Boon L, Blankenbach H, Hilgendorf I, von Zur Muhlen C, Reinöhl J, Sommer B, Marchini T, Febbraio MA, Weber C, Bode C, Peter K, Lutgens E*, Zirlik A* (2017). Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO). Thromb Haemost. 117:325-338. PMID 27853810. [A5, A1]

Wu Z, Rademakers T, Kiessling F, Vogt M, Westein E, Weber C, Megens RTA, van Zandvoort M (2017). Multi-Photon microscopy in cardiovascular research. Methods. 130:79-89. PMID 28434997. [A1, A10, Z1]

Xu Y, Wang Y, Yan S, Zhou Y, Yang Q, Pan Y, Zeng X, An X, Liu Z, Wang L, Xu J, Cao Y, Fulton DJ, Weintraub NL, Bagi Z, Hoda MN, Wang X, Li Q, Hong M, Jiang X, Boison D, Weber C, Wu C, Huo Y (2017). Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis. EMBO Mol Med. 9:1263-1278. PMID 28751580. [A1, A10]

Yi CX, Walter M, Gao Y, Pitra S, Legutko B, Kälin S, Layritz C, García-Cáceres C, Bielohuby M, Bidlingmaier M, Woods SC, Ghanem A, Conzelmann KK, Stern JE, Jastroch M, Tschöp MH (2017). TNFα drives mitochondrial stress in POMC neurons in obesity. Nat Commun. 10:15143. PMID 28489068. [A4]

Yin C, Mohanta SK, Maffia P, Habenicht AJ (2017). Editorial: tertiary lymphoid organs (TLOs): powerhouses of disease immunity. Front Immunol. 8:228. PMID 28321222. [C2]

Zahedi F*, Nazari-Jahantigh M*, Zhou Z, Subramanian P, Wei Y, Grommes J, Offermanns S, Steffens S, Weber C, Schober A (2017). Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. Cell Mol Life Sci. 74:359-372. PMID 27622243 *equal contribution. [A1, A10, B4, B9]

Zhao Z, Vajen T, Karshovska E, Dickhout A, Schmitt MM, Megens RTA, von Hundelshausen P, Koeppel TA, Hackeng TM, Weber C, Koenen RR (2017). Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice. J Cell Mol Med. 21:1523-1531. PMID 28211187. [A1, A2, A10, Z1]

Zhu M, Wei Y, Geißler C, Abschlag K, Corbalán Campos J, Hristov M, Möllmann J, Lehrke M, Karshovska E, Schober A (2017). Hyperlipidemia-induced microrna-155-5p improves β-cell function by targeting mafb. Diabetes. 66:3072-3084. PMID 28970282. [B4]