SFB 1123 Atherosclerosis-Mechanisms and Networks of Novel Therapeutic Targets
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Publications

2017
  • Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E. Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation. J Neuroinflam. 2017, 14:105-110. [A5, A1]
  • Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D,, Tilstam PJ, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, Winther MPJ, Noels H, Bernhagen J. Inhibition of Atherogenesis by the COP9 Signalosome Subunit 5 In Vivo. Proc Natl Acad Sci USA. Proc Natl Acad Sci U S A. 2017; 114:E2766-E2775. [A1, A3, B3]
  • Bonfert T, Friedel CC. Prediction of Poly(A) Sites by Poly(A) Read Mapping. PLOS ONE. 2017; 12:e0170914. [Z2]
  • Brænne I, Willenborg C, Tragante V, Kessler T, Zeng L, Reiz B, Kleinecke M, von Ameln S, Willer C, Laakso M, Wild P, Zeller T, Wallentin L, Franks P, Salomaa V, Dehghan A, Meitinger T, Samani N, Asselbergs F, Erdmann J, Schunkert H. A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors. Sci Rep. 2017; 7:10252. [B2]
  • Brænne I, Zeng L, Willenborg C, Tragante V, Kessler T, CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium, Willer CJ, Laakso M, Wallentin L, Franks PW, Salomaa V, Dehghan A, Meitinger T, Samani NJ, Asselbergs FW, Erdmann J, Schunkert H. Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk. PLoS One. 2017; 12:e0182999. [B2]
  • Clemmensen C, Müller TD, Woods SC, Berthoud HR, Seeley RJ, Tschöp MH. Gut-Brain Cross-Talk in Metabolic Control. Cell. 2017; 168:758-774. Review. [A4]
  • de Jong RJ, Leoni G, Drechsler M, Soehnlein O. The advantageous role of annexin A1 in cardiovascular disease. Cell Adh Migr. 2017; 11:261-274. Review. [A6, B5]
  • de Jong RJ, Paulin N, Lemnitzer P, Viola JR, Winter C, Ferraro B, Grommes J, Weber C, Reutelingsperger C, Drechsler M, Soehnlein O. Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report. Arterioscler Thromb Vasc Biol. 2017; 37:312-315. [A1, A6, B4, B5]
  • Dichgans M, Leys D. Vascular Cognitive Impairment. Circ Res. 2017; 120:573-591. Review. [B3]
  • Ding L, Deán-Ben XL, BurtonNC, Sobol RW, Ntziachristos V, Razansky D. Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography. IEEE Transactions on Medical Imaging. 2017; 36: 1676-1685. [Z1]
  • Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C. Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies. Circulation. 2017; 136:388-403. [A1, A5, A6, B1, B4, B5, Z1]
  • Döring Y, Soehnlein O, Weber C. Neutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis. Circ Res. 2017; 120:736-743. Review. [A1, A6, B4, B5]
  • Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K, Caamaño J, Rülicke T, Moss P, Megens RTA, von Andrian UH, Hidalgo A, Weber C*, Rot A*. Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. Nat Immunol. 2017; 18:753-761. [A1, Z1]
  • Ebrahim M, Jamasbi J, Adler K, Megens RT, M’Bengue Y, Blanchet X, Uhland K, Ungerer M, Brandl R, Weber C, Elia N, Lorenz R, Münch G, Siess W. Dimeric glycoprotein VI binds to collagen but not to fibrin: Thromb. Haemost. in press. [A1, B8, Z1]
  • Emdin CA, Khera AV, Klarin D, Natarajan P, Zekavat SM, Nomura A, Haas ME, Aragam K, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gormley P, Palotie A, Stitziel N, Gupta N, Danesh JN, Saleheen D, Gabriel SB, Kathiresan S. Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling. Circulation. in press. [B2]
  • Ferrari E, Lutgens E, Weber C, Gerdes N. Atherosclerosis: cell biology and lipoproteins focus on epigenetic modification and macrophage biology. Curr Opin Lipidol. 2017; 28:220-221. Review. [A5]
  • Fischer K, Ruiz HH, Jhun K, Finan B, Oberlin DJ, van der Heide V, Kalinovich AV, Petrovic N, Wolf Y, Clemmensen C, Shin AC, Divanovic S, Brombacher F, Glasmacher E, Keipert S, Jastroch M, Nagler J, Schramm KW, Medrikova D, Collden G, Woods SC, Herzig S, Homann D, Jung S, Nedergaard J, Cannon B, Tschöp MH, Müller TD, Buettner C. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nat Med. 2017. 23:623-630. [A4]
  • Gaertner F, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt M, Massberg S. Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria. Cell. 2017; 171:1368-1382.e23. [A7, B6]
  • Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, Buijs RM, Woods SC, Kalsbeek A, Seeley RJ, Nawroth PP, Bidlingmaier M, Tschöp MH, Yi CX. Dietary sugars, not lipids, drive hypothalamic inflammation. Mol Metab. 2017; 6:897-908. [A4]
  • Holdt LM, Kohlmaier A, Teupser D. Molecular roles and function of circular. RNAs in eukaryotic cells. Cell Mol Life Sci. in press. Review. [B1]
  • Horckmans M, Bianchini M, Santovito D, Megens RTA, Springael JY, Negri I, Vacca M, Eusanio M, Moschetta A, Weber C, Duchene J, Steffens S. Pericardial adipose tissue regulates granulopoiesis, fibrosis and cardiac fuunction after myocardial infarction. Circulation. In press. [A1, C1, Z1]
  • Horckmans M, Ring L, Duchene J, Santovito D, Schloss MJ, Drechsler M, Weber C, Soehnlein O, Steffens S. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype. Eur Heart J. 2017; 38:187-197. [A1, A6, B4, B5, C1]
  • Jall S, Sachs S, Clemmensen C, Finan B, Neff F, DiMarchi RD, Tschöp MH, Müller TD, Hofmann SM. Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice. Mol Metab. 2017; 6:440-446.[A4]
  • Jung C, Lichtenauer M, Strodthoff D, Winkels H, Wernly C, Bürger C, Kamchybekov U, Lutgens E, Figulla HR, Gerdes N. Alterations in systemic levels of Th1, Th2 and Th17 cytokines in overweight adolescents and obese mice. Pediatr Diabetes. 2017; 18:714-721. [A5]
  • Karlas A, Reber J, Diot G, Bozhko D, Anastasopoulou M, Ibrahim T, Schwaiger M, Hyafil F, Ntziachristos V. Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept. Biomed. Opt. Express 2017; 8:3395-3403. [Z1]
  • Kessler T*, Wobst J*, Wolf B, Eckhold J, Vilne B, von Ameln S, Dang TA, Sager HB, Rumpf PM, Aherrahrou R, Kastrati A, Bjoerkegren JLM, Erdmann J, Lusis AJ, Civelek M, Kaiser FJ, Schunkert H. Functional characterization of the GUCY1A3 coronary artery disease risk locus. Circulation. 2017; 136:476-489. [B2]
  • Keuper M, Sachs S, Walheim E, Berti L, Raedle B, Tews D, Fischer-Posovszky P, Wabitsch M, Hrabě de Angelis M, Kastenmüller G, Tschöp MH, Jastroch M, Staiger H, Hofmann SM. Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors. Mol Metab. 2017; 6:1226-1239. [A4]
  • Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S; Myocardial Infarction Genetics Consortium, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA. 2017; 317:937-946. [B2]
  • Kim BS, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R. D-dopachrome tautomerase in adipose tissue inflammation and wound repair. J Cell Mol Med. 2017; 21:35-45. [A3]
  • Kleinert M, Clemmensen C, Stemmer K, Müller TD, DiMarchi RD, Tschöp MH. Emerging Poly-Agonists for Obesity and Type 2 Diabetes. Obesity (Silver Spring). 2017; 25:1647-1649. [A4]
  • Kusters P, Seijkens T, Bürger C, Legein B, Winkels H, Gijbels M, Barthels C, Bennett R, Beckers L, Atzler D, Biessen E, Brocker T, Weber C, Gerdes N, Lutgens E. Constititive CD40 signaling in dendritic cells limits atherosclerosis by provoking inflammatory bowel disease and ensuing cholesterol malabsorption. Am J Pathol. 2017; 187:2912-2919. [A5, A1]
  • Lubitz SA, Parsons OE, Anderson CD, Benjamin EJ, Malik R, Weng LC, Dichgans M, Sudlow CL, Rothwell PM, Rosand J, Ellinor PT, Markus HS, Traylor M; WTCCC2, International Stroke Genetics Consortium, and AFGen Consortia. Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms. Stroke. 2017; 48:1451-1456. [B3]
  • Malekzadeh-Najafabadi J, Prakash J, Ntziachristos V. Nonlinear optoacoustic readings from diffusive media at near-infrared wavelengths. J. Biophotonics. 2017; e201600310. [Z1]
  • Malik R, Dau T, Gonik M, Sivakumar A, Deredge DJ, Edeleva EV, Götzfried J, van der Laan SW, Pasterkamp G, Beaufort N, Seixas S, Bevan S, Lincz LF, Holliday EG, Burgess AI, Rannikmäe K, Minnerup J, Kriebel J, Waldenberger M, Müller-Nurasyid M, Lichtner P, Saleheen D; International Stroke Genetics Consortium, Rothwell PM, Levi C, Attia J, Sudlow CL, Braun D, Markus HS, Wintrode PL, Berger K, Jenne DE, Dichgans M. A common coding variant in SERPINA1 increases the risk for large artery stroke. Proc Natl Acad Sci U S A. 2017; 114:3613-3618. [B3]
  • Malik R, et al.,…et Debette S, Dichgans M. Multi-ancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genetics (provisionally accepted). [B3]
  • Mojica Muñoz AK, Jamasbi J, Uhland K, Degen H, Münch G, Ungerer M, Brandl R, Megens RT, Weber C, Lorenz R, Siess W. Recombinant GPVI-Fc added to single or dual antiplatelet therapy in vitro prevents plaque-induced platelet thrombus formation. Thromb Haemost. 2017; 117:1651-1659. [B8, Z1]
  • Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I, Lai FY, Hopewell JC, Giannakopoulou O, Jiang T, Hamby SE, Di Angelantonio E, Assimes TL, Bottinger EP, Chambers JC, Clarke R, Palmer CNA, Cubbon RM, Ellinor P, Ermel R, Evangelou E, Franks PW, Grace C, Gu D, Hingorani AD, Howson JMM, Ingelsson E, Kastrati A, Kessler T, Kyriakou T, Lehtimäki T, Lu X, Lu Y, März W, McPherson R, Metspalu A, Pujades-Rodriguez M, Ruusalepp A, Schadt EE, Schmidt AF, Sweeting MJ, Zalloua PA, AlGhalayini K, Keavney BD, Kooner JS, Loos RJF, Patel RS, Rutter MK, Tomaszewski M, Tzoulaki I, Zeggini E, Erdmann J, Dedoussis G, Björkegren JLM; EPIC-CVD Consortium; CARDIoGRAMplusC4D; UK Biobank CardioMetabolic Consortium CHD working group, Schunkert H*, Farrall M*, Danesh J*, Samani NJ*, Watkins H*, Deloukas P*. Association analyses based on false discovery rate implicate many new loci for coronary artery disease. Nat Genet. 2017; 49:1385-1391. [B2]
  • Nicolaou A, Northoff BH, Zhao Z, Kohlmaier A, Sass K, Rose-John S, Steffens S, Weber C, Teupser D, Holdt LM. The ADAM17 metalloproteinase maintains arterial elasticity . Thromb Haemost. In press. [A1, B1, C1]
  • Nicolaou A, Zhao Z, Northoff BH, Sass K, Herbst A, Kohlmaier A, Chalaris A, Wolfrum C, Weber C, Steffens S, Rose-John S, Teupser D, Holdt LM. Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice. Arterioscler Thromb Vasc Biol. 2017; 37:247-257 [A1, B1, C1]
  • Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini P, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JM, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri M, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh JN, Ardissino D, Gabriel SB, Willer CJ, Abecasis G, Saleheen D, Kubo M, Kato N, YI Chen, Dewey F, Kathiresan S. Protein Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res. 2017; 121:81-88. [B2]
  • Paulin N, Döring Y, Kooijman S, Blanchet X, Viola JR, de Jong R, Mandl M, Hendrikse J, Schiener M, von Hundelshausen P, Vogt A, Weber C, Bdeir K, Hofmann SM, Rensen PC, Drechsler M, Soehnlein O. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance. EBioMedicine. 2017; 16:204-211. [A1, A2, A4, A6, B4, B5]
  • Pfeiler S, Stark K, Massberg S, Engelmann B. Propagation of thrombosis by neutrophils and extracellular nucleosome networks. Haematologica. 2017; 102:206-213. [A7, B6]
  • Phuah CL, Dave T, Malik R, Raffeld MR, Ayres AM, Goldstein JN, Viswanathan A, Greenberg SM, Jagiella JM, Hansen BM, Norrving B, Jimenez-Conde J, Roquer J, Pichler A, Enzinger C, Montaner J, Fernandez-Cadenas I, Lindgren A, Slowik A, Schmidt R, Biffi A, Rost N, Langefeld CD, Markus HS, Mitchell BD, Worrall BB, Kittner SJ, Woo D, Dichgans M, Rosand J, Anderson CD; METASTROKE; NINDS-SiGN Consortium; International Stroke Genetics Consortium. Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke. Brain. 2017; 140:2663-2672. [B3]
  • Quarta C, Clemmensen C, Zhu Z, Joseph S, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Yang B, Vettorazzi S, Hofmann SM, Bakhti M, Ponce MB, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Tuckermann J, Hrabe de Angelis M, Cota D, Latz E, Sandoval D, Müller TD, Yang B, DiMarchi R, Finan F, Tschöp MH. Molecular Integration of Incretin and Glucocorticoid Reverses Metabolic Inflammation and Obesity. Cell Metab. 2017; 26:620-632.e6. [A4, B7]
  • Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM; Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC). COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. Neurology. In press. [B3]
  • Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat ML, Boilard E, Buzas EI, Caporali A, Dignat-George F, Evans PC, Lacroix R, Lutgens E, Ketelhuth DFJ, Nieuwland R, Toti F, Tunon J, Weber C, Hoefer IE. Microvesicles in vascular homeostasis and diseases. Position paper of the European society of cardiology (ESC) working group on atherosclerosis and vascular biology. Thromb. Haemost 2017, 117: 1296-1316. [A5, A1]
  • Rinne P, Rami M, Nuutinen S, Lyytikäinen L-P, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimäki T, Weber C, Steffens S. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. Circulation. 2017; 136:83-97. [A1, C1]
  • Roberts S, Seeger M, Jiang Y, Mishra A, Sigmund F, Stelzl A, Lauri A, Symvoulidis P, Rolbieski H, Preller M, Deán-Ben XL, Razansky D, Orschmann T, Desbordes SC, Vetschera P, Bach T, Ntziachristos V, Westmeyer GG. Calcium Sensor for Photoacoustic Imaging. JACS. In press. [Z1]
  • Saleheen D, Zhao W, Young R, Nelson CP, Ho W, Ferguson J, Rasheed A, Ou K, Nurnberg ST, Bauer RC, Goel A, Do R, Stewart AFR, Hartiala J, Zhang W, Thorleifsson G, Strawbridge RJ, Sinisalo J, Kanoni S, Sedaghat S, Marouli E, Kristiansson K, Hua J, Scott R, Gauguier D, Shah S, Smith AV, van Zuydam NR, Cox AJ, Willenborg C, Kessler T, Zeng L, Province MA, Ganna A, Lind L, Pedersen NL, White CC, Joensuu A, Kleber ME, Hall AS, März W, Salomaa V, O'Donnell C, Ingelsson E, Feitosa MF, Erdmann J, Bowden DW, Palmer CN, Gudnason V, De Faire U, Zalloua P, Wareham N, Thompson JR, Kuulasmaa K, Dedoussis G, Perola M, Dehghan A, Chambers JC, Kooner J, Allayee H, Deloukas P, McPherson R, Stefansson K, Schunkert H, Kathiresan S, Farrall M, EPIC-CVD, Frossard P, Rader DJ, Samani NJ, PROMIS, CARDIoGRAMplusC4D, Reilly MP. Loss of cardio-protective effects at the ADAMTS7 locus due to gene-smoking interactions. Circulation. 2017; 135:2336-2353. [B2]
  • Schloss MJ, Hilby M, Nitz K, Guillamat Prats R, Ferraro B, Leoni G, Soehnlein O, Kessler T, He W, Luckow B, Horckmans M, Weber C, Duchene J, Steffens S. Ly6Chigh Monocytes Oscillate in the Heart During Homeostasis and After Myocardial Infarction-Brief Report. Arterioscler Thromb Vasc Biol. 2017; 37:1640-1645. [A1, A6, B4, B5, C1]
  • Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer, M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van ‘t Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E. TRAF-STOPping atherosclerosis: targeting of CD40-induced TRAF6 signaling in macrophages reduces de novo and established atherosclerosis. J Amer. Coll. Cardiol. 2017, in press. [A5, A1, A6, B5]
  • Shnaiderman R, Wissmeyer G, Seeger M, Soliman D, Estrada H, Razansky D, Rosenthal A, Ntziachristos V. Fiber interferometer for hybrid optical and optoacoustic intravital microscopy. Optica. In press. [Z1]
  • Soehnlein O, Steffens S, Hidalgo A, Weber C. Neutrophils as protagonists and targets in chronic inflammation. Nat Rev Immunol. 2017; 17:248-261. Review. [A1, A6, B4, B5, C1]
  • Stark K, Pekayvaz K, Massberg S. Role of pericytes in vascular immunosurveillance. Front Biosci (Landmark Ed). 2018; 23:767-781. [A7]
  • Steffens S, Winter C, Schloss MJ, Hidalgo A, Weber C, Soehnlein O. Circadian Control of Inflammatory Processes in Atherosclerosis and Its Complications. Arterioscler Thromb Vasc Biol. 2017; 37:1022-1028. Review. [A1, A6, B4, B5, C1]
  • Steven S, Dib M, Hausding M, Kashani F, Oelze M, Kröller-Schön S, Hanf A, Daub S, Roohani S, Gramlich Y, Lutgens E, Schulz E, Becker C, Lackner KJ, Kleinert H, Knosalla C, Niesler B, Wild PS, Münzel T, Daiber A. CD40L control obesity-associated vascular inflammation, oxidative stress and endothelial dysfunction in mice – translational aspects for man. Cardiovasc Res. in press. [A5]
  • Stremmel C, Schuchert C, Wagner F, Thaler R, Weinberger T, Pick R, Mass E, Ishikawa-Ankerhold HC, Margraf A, Hutter S, Vagnozzi R, Klapproth K, Frampton J, Yona S, Scheiermann C, Molkentin JD, Jeschke U, Moser M, Sperandio M, Massberg S, Geissmann F, Schulz C. Yolk sac macrophage progeni-tors traffic to the embryo during defined stages of development. Nat comm. in press. [A7, A8]
  • Tiedt S, Prestel M, Kautzky V, Duering M, Northoff B, Malik R, Klein M, Dorn F, Krohn K, Teupser D, Holdt LM, Dichgans M. RNA-seq identifies circulating miR-125a-5p, miR-125b-5p and miR-143-3p as potential biomarkers for acute ischemic stroke. Circ Res. 2017; 121:970-980. [B1, B3]
  • Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, Chauhan G, Debette S, Bis JC, Longstreth WT Jr, Ikram MA, Launer LJ, Seshadri S; METASTROKE, UK Young Lacunar DNA Study, NINDS Stroke Genetics Network, Neurology Working Group of the CHARGE Consortium, Hamilton-Bruce MA, Jimenez-Conde J, Cole JW, Schmidt R, Słowik A, Lemmens R, Lindgren A, Melander O, Grewal RP, Sacco RL, Rundek T, Rexrode K, Arnett DK, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Pulit SL, Wong Q, Rich SS, de Bakker PI, McArdle PF, Woo D, Anderson CD, Xu H, Heitsch L, Fornage M, Jern C, Stefansson K, Thorsteinsdottir U, Gretarsdottir S, Lewis CM, Sharma P, Sudlow CL, Rothwell PM, Boncoraglio GB, Thijs V, Levi C, Meschia JF, Rosand J, Kittner SJ, Mitchell BD, Dichgans M, Worrall BB, Markus HS, on behalf of the International Stroke Genetics Consortium. Genetic Variation at 16q24.2 is associated with small vessel stroke. Ann Neurol. 2017; 81:383-394. [B3]
  • Tzoumas S, Ntziachristos V. Spectral unmixing techniques for optoacoustic imaging of tissue pathophysiology. Phil.Trans.R.Soc.A 2017; 375:20170262. Review. [Z1]
  • van den Berg SM, van Dam AD, Rensen PCN, de Winther M, Lutgens E. Immune modulation of and by brown(ing) adipose tissue in obesity. Endocrine reviews 2017, 17: 46-68. Review. [A5]
  • Van der Vorst E, Zhao Z, Rami M, Holdt LM, Teupser D, Steffens S, Weber C. Contrasting effects of myeloid and endothelial ADAM17 on atherosclerosis development. Thromb Haemost. 2017. 28;117:644-646. [A1, B1, C1]
  • van der Vorst EPC, Maas SL, Ortega-Gomez A, Hameleers JMM, Bianchini M, Asare Y, Soehnlein O, Döring Y, Weber C, Megens RTA. Functional ex-vivo Imaging of Arterial Cellular Recruitment and Lipid Extravasation. Bio Protoc. 2017; 7, pii: 2344. [A1, A6, B4, B5, Z1]
  • Varela L, Suyama S, Huang Y, Shanabrough M, Tschöp MH, Gao XB, Giordano FJ, Horvath TL. Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons. Diabetes. 2017; 66:1511-1520. [A4]
  • Vilne B, Skogsberg J, Foroughi Asl H, Talukdar HA, Kessler T, Björkegren JLM, Schunkert H. Network Analysis Reveals a Causal Role of Mitochondrial Gene Activity in Atherosclerotic Lesion Formation. Atherosclerosis. 2017; 267:39-48. [B2]
  • von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, Döring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C. Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Sci Transl Med. 2017; 9, pii: eaah6650. [A1, A2, A5, A6, B4, B5, Z1]
  • Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, Franzén O, Schadt EE, Björkegren JL, Weeke PE, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kruppa J, Mahajan A, Scott RA, Willenborg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer C, El-Mokhtari NE, Franke A, Heilmann S, Hengstenberg C, Hoffmann P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Virtamo J, Nikpay M, Olivieri O, Provost S, AlQarawi A, Robertson NR, Akinsansya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Müller-Nurasyid M, Strauch K, Varga TV, Waldenberger M; Wellcome Trust Case Control Consortium, Zeng L, Chowdhury R, Salomaa V, Ford I, Jukema JW, Amouyel P, Kontto J; MORGAM Investigators, Nordestgaard BG, Ferrières J, Saleheen D, Sattar N, Surendran P, Wagner A, Young R, Howson JM, Butterworth AS, Danesh J, Ardissino D, Bottinger EP, Erbel R, Franks PW, Girelli D, Hall AS, Hovingh GK, Kastrati A, Lieb W, Meitinger T, Kraus WE, Shah SH, McPherson R, Orho-Melander M, Melander O, Metspalu A, Palmer CN, Peters A, Rader DJ, Reilly MP, Loos RJ, Reiner AP, Roden DM, Tardif JC, Thompson JR, Wareham NJ, Watkins H, Willer CJ, Samani NJ*, Schunkert H*, Deloukas P*, Kathiresan S*; Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators. Systematic evaluation of pleiotropy identifies six further loci associated with coronary artery disease. J Am Coll Cardiol. 2017; 69:823-836. [B2]
  • Weber C, von Hundelshausen P. CANTOS Trial Validates the Inflammatory Pathogenesis of Atherosclerosis: Setting the Stage for a New Chapter in Therapeutic Targeting. Circ Res. 2017;121:1119-1121. Commentary. [A1, A2]
  • Wierer M, Prestel M, Schiller H, Yan G, Schaab C, Azghandi S, Werner J, Kessler T, Malik R, Murgia M, Aherrahrou Z, Schunkert H, Dichgans M, Mann M. Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression. Mol Cell Proteomics. In press. [B2, B3]
  • Winkels H, Meiler S, Smeets E, Lievens D, Engel D, Spitz C, Bürger C, Beckers L, Dandl A, Reim S, Hristov M, Megens RTA, Schmitt MM, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N. CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidemic mice. Eur Heart J. in press. [A5, A1, Z1]
  • Winkels H, Meiler S, Smeets E, Lievens D, Engel E, Spitz C, Bürger C, Rinne P, Beckers L, Dandl A, Reim S, Ahmadsei M, Van den Bossche J, Holdt LM, Megens RTA, Schmitt MM, de Winther M, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E*, Gerdes N*. CD70 limits atherosclerosis and promotes macrophage function. Thromb Haemost, 2017, 117:164-175. [A5, Z1, A1]
  • Wolf D, Bukosza N, Engel D, Poggi M, Jehle F, Anto Michel N, Chen YC, Colberg C, Hoppe N, Dufner B, Boon L, Blankenbach H, Hilgendorf I, von Zur Muhlen C, Reinöhl J, Sommer B, Marchini T, Febbraio MA, Weber C, Bode C, Peter K, Lutgens E*, Zirlik A*. Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO). Thromb Haemost. 2017, 117:325-338. [A5, A1]
  • Yi CX, Walter M, Gao Y, Pitra S, Legutko B, Kälin S, Layritz C, García-Cáceres C, Bielohuby M, Bidlingmaier M, Woods SC, Ghanem A, Conzelmann KK, Stern JE, Jastroch M, Tschöp MH. TNFα drives mitochondrial stress in POMC neurons in obesity. Nat Commun. 2017; 8:15143. [A4]
  • Zahedi F, Nazari-Jahantigh M, Zhou Z, Subramanian P, Wei Y, Grommes J, Offermanns S, Steffens S, Weber C, Schober A. Dicer generates a microRNA regulatory network in smooth muscle cells during vascular repair that limits neointima formation. Cell Mol Life Sci. 2017; 74:359-372.[ A1, B4, C1]
  • Zhao Z, Vajen T, Karshovska E, Dickhout A, Schmitt MM, Megens RT, von Hundelshausen P, Koeppel TA, Hackeng TM, Weber C, Koenen RR. Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice. J Cell Mol Med. 2017; 21:1523-1531. [A1, A2, Z1]
  • Zhu L, Yang J, Bromberger T, Holly A, Lu F, Liu H, Sun K, Klapproth S, Hirbawi J, Byzova TV, Plow EF, Moser M*, Qin J*. Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation. Nat Commun. 2017; 8:1744. [A8]
  • Zhu M, Wei Y, Geißler C, Abschlag K, Campos JC, Hristov M, Möllmann J, Lehrke M, Karshovska E, Schober A. Hyperlipidemia-Induced MicroRNA-155-5p Improves β-cell Function by Targeting Mafb. Diabetes. 2017; 66:3072-3084. [B4]
  • Submitted
  • Asare Y, Bokov Y*, Yu LL*, Megens RT, Azghandi S, Tiedt S, Prestel P, El Bounkari O, Liesz A, Schneider M, Haffner C, Bernhagen J, Dichgans M. Targeting HDAC9 Limits NF-κB Signaling and Attenuates Experimental Atherosclerosis: Prospects for Pharmacological Intervention. [A3, B3, Z1]
  • Bianchini M,* Duchêne J,* Santovito D, Evrard M, Winkels H, Aslani M, Mohanta SK, von Hundelshausen P, Steffens S, Gerdes N, Ng LG, Weber C,* Megens RT,*. CD274/PD-L1 marks patrolling Ly6Clow monocytes and reveals a site for monocyte conversion in the bone marrow. [A1, A2, A5, Z1, C1]
  • Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz C, Doppenberg-Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag T, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E. Western diet triggers NLRP3-dependent persistent functional reprograming of myeloid cells. [B7]
  • Damby DE, Horwell CJ, Baxter PJ, Kueppers U, Schnurr M, Dingwell DB, Duewell P. Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages. [B7]
  • Fischer K, Dyar KA, Kleinert M, Brielmeier M, Collins S, Clemmensen C, Fedl A, Finan B, Gessner A, Jastroch M, Keipert S, Klingenspor M, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Zorn J, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD. The scaffold protein p62 regulates adaptive thermogenesis via ATF2 translocation.[A4]
  • Gao Y, Lehti M, Donelan E, Al-Massadi O, Chandler R, Weber J, Yi YX, Woods SC, Tschöp MH, Hofmann SM. Circulating HDL levels control hypothalamic astrogliosis via ApoA-I. [A4]
  • González-Ramos S, Paz-García M, Rius S, del Monte-Monge A, Rodríguez C, Tawakol A, Rosales-Mendoza CE, Andrés V, Martínez-González J, Lasunción Ma, Martín-Sanz P, Fernandez-Velasco M, Soehnlein O*, Boscá L*. Endothelial NOD1 directs myeloid cell recruitment in atherosclerosis through VCAM-1. [A6, B5]
  • Hall KT*, Kessler T*, Buring JE, Passow D, Sesso H, Zee R, Ridker PM, Chasman DI*, Schunkert H*. Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin. [B2]
  • Horckmans M, Schloss, Weber C, Steffens S. 2-arachidonoylglycerol mobilizes myeloid cells via cannabinoid receptor CB2 and promotes their cardiac recruitment. [A1, C1]
  • Kellnberger S, Soliman D, Tserevelakis GJ, Seeger M, Yang H, Karlas A, Prade L, Ntziachristos V. Optoacoustic microscopy at multiple discrete frequencies. [Z1]
  • Lee S, Ng J, Hinkel R, Müller O, Megens RT, Nelson P, Laugwitz KL, Weber C, Sperandio M, Ogris M, Kupatt C. Nanoparticles optimize peptide-guided AAV-retargeting towards microvascular endothelium. [A1, Z1]
  • Mak'Anyengo M, Duewell P, Reichl C, Hörth C, Lehr HA, Fischer S, Clavel T, Denk G, Hohenester S, Kobold S, Endres S, Schnurr M, Bauer C. Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut. [B7]
  • Massner C, Sigmund F, Pettinger S, Seeger M, Hartmann C, NIvleva NP, Niessner R, Fuchs H, Hrabé de Angelis M, Stelzl A, Lal Koonakampully N, Rolbieski H, Wiedwald U, Wurst W, Ntziachristos V, Winklhofer M, Westmeyer GG. Genetically controlled lysosomal entrapment of superparamagnetic ferritin for multimodal and multiscale imaging and actuation with low tissue attenuation. [Z1]
  • Novotny J, Chandraratne S, Weinberger T, Philipp V, Stark K, Ehrlich A, Pircher J, Pelisek J, Massberg S, von Brühl ML, Schulz C. Histological comparison of arterial thrombi in mice and men. [A7, B6]
  • Paulin N, Viola JR, Maas S, Fernandes-Alnemri T, Chavakis T, Weber C, Drechsler M, Döring Y, Soehnlein O. Double-strand DNA sensing Aim2 inflammasome regulates atherosclerotic plaque destabilization. [A1, A6, B4, B5]
  • Pekayvaz K, Hoseinpour P, Coletti R, Titova R, Ishikawa-Ankerhold H, Kilani B, Lorenz M, Khandoga A, Fingerle-Rowson G, Bucala R, Schulz S, Massberg S, Stark K. Activation of canonical proinflammatory pathways in dedifferentiated NG2+ smooth muscle cells exerts atheroprotective effects. [A7]
  • Pfeiler S, Thakur M, Vrabcova P, Megens RT, Joshi U, Coletti R, Samara V, Müller-Stoy G, Bruns CJ, Weber C, Massberg S, Engelmann B. Cellular internalization of microvesicles: intracellular segregation and in vivo persistence of tumor microvesicles. [A1, B6, Z1]
  • Pircher J, Czermak T, Gaitzsch E, Margraf A, Grommes J, Weckbach L, Kraemer B, Sperandio M, Walzog B, Soehnlein O, Mannell H, Massberg S, Schulz C, Cathelicidins induce platelet activation and platelet-neutrophil-aggregation thereby enhancing the inflammatory response. [A7, A6, B5]
  • Poh PS, Schmauss V, McGovern JA, Schmauss D, Theodoropoulos C, Chhaya MP, Foehr P, Seeger M, Ntziachristos V, Hutmacher DW, van Griensven M, Schantz JT, Balmayor ER. Non-linear optical microscopy and histological analysis of collagen, elastin and lysyl oxidase expression in breast capsular contracture. [Z1]
  • Rami M, Guillamat Prats, Rinne P, Ring L, Salvermoser M, Blanchet X, Megens R, Doering Y, Walzog B, Soehnlein O, Weber C, Faussner A, Steffens S. Chronic intake of the selective serotonin reuptake inhibitor fluoxetine enhances atherosclerosis in mice. [A1, A6, C1, Z1]
  • Rinne P, Kadiri JJ, Velasco-Delgado M, Nuutinen S, Viitala M, Hollmén M, Rami M, Savontaus E, Steffens S. Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E-/- Mice. [C1]
  • Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Erlandsson Harris H, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A. Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. [A3, B3]
  • Schmitz C, Noels H, Straußfeld E, El Bounkari O, Megens RT, Krammer C, Sternkopf M, Alampour-Rajabi S, Tilstam PV, Gerdes N, Bürger C, Kapurniotu A, Bucala R, Jankowski J, Weber C, Bernhagen J. An atheroprotective anti-oxidized LDL autoantibody profile in Mif-deficient mice reveals a novel link between MIF and B-cells in atherosclerosis. [A1, A3, A5, Z1]
  • Schmitz C, Straußfeld E, El Bounkari O, Tilstam PV, Gerdes N, Bürger C, Kapurniotu A, Bucala R, Jankowski J, Weber C, Noels H, Bernhagen J. An atheroprotective anti-oxidized LDL autoantibody profile in Mif-deficient mice reveals a novel link between MIF and B-cells in atherosclerosis. [A1, A3, A5]
  • Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Froese A, Adrover JM, Ortega-Gómez A, Marschner J, Paulin N, Lemnitzer N, Schumski A, Winter C, Schoufour T, Hartwig H, González Ramos S, Kamp F, Megens RTA, Weber C, Lutgens E, Daemen M, Anders HJ, Nikolaev VO, Hidalgo A, Pellequer JL, Wong GCL, Nicolaes G, Soehnlein O. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. [A1, A5, A5, B5, Z1]
  • Stark K, Schubert I, Joshi U, Vrabcova P, Pfeiler S, Schmidergall T, Stockhausen S, Bäumer M, Chandraratne S, von Brühl M-L, Lorenz M, Coletti R, Reese S, Laitinen I, Wörmann S, Algül H, Bruns CJ, Ware J, Mackman N, Engelmann B, Massberg S Distinct pathogenesis of cancer-associated venous thrombosis identifies new antithrombotic targets in vivo. [A7, B6]
  • Vajen, T, Werner, I, Projahn, D, Staudt, M, Curaj, A, Soenmez, TT, Simsekyilmaz, S, Hackeng, TM, Von Hundelshausen, P, Koenen, RR, Weber C, Liehn, EA. Blocking heteromerization of platelet chemokines ccl5 and cxcl4 reduces inflammation and preserves heart function after myocardial infarction. [A1, A2]
  • Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Schumski A, Winter J, Drechsler M, de Jong R, Immler R, Sperandio M, Hristov M, Zeller T, Weber C, Viola JR, Hidalgo A, Scheiermann C, Soehnlein O. Chrono-pharmacological targeting of the CCL2-CCR2 axis ameliorates atherosclerosis. [A1, A6, B4, B5]
  • Yin C, Ackermann S, Mohanta SK, Ma Z, Nietzsche S, Westermann M, Peng L, Bontha SV, Srikakulapu P, Beer M, Megens RT, Hildner M, Steffens S, Weber C, Zipfel PF, Skerka C, Habenicht AJ. Apolipoprotein E: A Master Regulator of Choroid Plexus Inflammation. [A1, Z1, C1]
  • Zhao, Z, Vajen, T, Karshovska, E, Dickhout, A, Schmitt, MM, Megens, RT, von Hundelshausen, P, Koeppel, TA, Hackeng, TM, Weber C, Koenen, RR . Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice. [A1, A2, Z1]


2016

  • LeBlanc M, Zuber V, Andreassen BK, Witoelar A, Zeng L, Bettella F, Wang Y, McEvoy LK, Thompson WK, Schork AJ, Reppe S, Barrett-Connor E, Ligthart S, Dehghan A, Gautvik KM, Nelson CP, Schunkert H, Samani NJ; CARDIoGRAM Consortium, Ridker PM, Chasman DI, Aukrust P, Djurovic S, Frigessi A, Desikan RS, Dale AM, Andreassen OA. Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors. Circ Res, 2016; 118:83-94. [ Project B2]
  • Müller M, Kessler T, Schunkert H, Erdmann J, Tennstedt S. Classification of ADAMTS binding sites: The first step toward selective ADAMTS7 inhibitors. Biochem Biophys Res Commun, 2016; 471:380-5. [Project B2]
  • Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kanoni S, Kruppa J, Mahajan A, Scott RA, Willenberg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer CM, El-Mokhtari NE, Franke A, Gottesman O, Heilmann S, Hengstenberg C, Hoffman P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alvar M, Moebus S, Morris AD, Müller-Nurasyid M, Nikpay M, Olivieri O, Lemieux Perreault LP, AlQarawi A, Robertson NR, Akinsanya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Strauch K, Varga TV, Waldenberger M, Zeng L, Kraja AT, Liu C, Ehret GB, Newton-Cheh C, Chasman DI, Chowdhury R, Ferrario M, Ford I, Jukema JW, Kee F, Kuulasmaa K, Nordestgaard BG, Perola M, Saleheen D, Sattar N, Surendran P, Tregouet D, Young R, Howson JM, Butterworth AS, Danesh J, Ardissino D, Bottinger EP, Erbel R, Franks PW, Girelli D, Hall AS, Hovingh GK, Kastrati A, Lieb W, Meitinger T, Kraus WE, Shah SH, McPherson R, Orho-Melander M, Melander O, Metspalu A, Palmer CN, Peters A, Rader D, Reilly MP, Loos RJ, Reiner AP, Roden DM, Tardif JC, Thompson JR, Wareham NJ, Watkins H, Willer CJ, Kathiresan S, Deloukas P, Samani NJ, Schunkert H. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med, 2016; 374:1134-44. [Project B2]
  • Kessler T, Erdmann J, Vilne B, Bruse P, Kurowski V, Diemert P, Schunkert H, Sager HB. Serum microRNA-1233 is a specific biomarker for diagnosing acute pulmonary embolism. J Transl Med, 2016; 14:120. [Project B2]
  • Wobst J, von Ameln S, Wolf B, Wierer M, Dang TA, Sager HB, Tennstedt S, Hengstenberg C, Koesling D, Friebe A, Braun SL, Erdmann J, Schunkert H, Kessler T. Stimulators of the soluble guanylyl cyclase: promising functional insights from rare coding atherosclerosis-related GUCY1A3 variants. Basic Res Cardiol 2016; 111:51. [Project B2]
  • Khera AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, Duga S, Bis JC, van Duijn CM, Cupples LA, Psaty B, Rader DJ, Danesh J, Schunkert H, McPherson R, Farrall M, Watkins H, Lander E, Wilson JG, Correa A, Boerwinkle E, Merlini PA, Ardissino D, Saleheen D, Gabriel S, Kathiresan S. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol, 2016; 67:2578-89. [Project B2]
  • Kessler T, Vilne B, Schunkert H. The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease. EMBO Mol Med, 2016; 8:688-701. Review. [Project B2]
  • Braster Q, Silvestre Roig C, Hartwig H, Beckers L, den Toom M, Döring Y, Daemen MJ, Lutgens E, Soehnlein O. Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice. PLoS One. 2016; 11:e0163922. [Project A5, A6, B5]
  • Ortega Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong R, Megens RT, Jamasbi J, Döring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O. Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment. Circulation. 2016 Sep 22. pii: CIRCULATIONAHA.116.024790. [Epub ahead of print] [Project A6, B5, B8, Z1]
  • Soehnlein O. Monocytes Chat With Atherosclerotic Lesions. Arterioscler Thromb Vasc Biol. 2016; 6:1720-1. [Poject A6, B5]
  • Viola J, Lemnitzer P, Jansen Y, Csaba G, Winter C, Neideck C, Silvestre-Roig C, Dittmar G, Döring Y, Drechsler M, Weber C, Zimmer R, Cenac N, Soehnlein O. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. Circ Res. 2016 Aug 16. pii: CIRCRESAHA.116.309492. [Epub ahead of print] [Project A6, B5, Z2]
  • Schloss MJ, Horckmans M, Nitz K, Duchene J, Drechsler M, Bidzhekov K, Scheiermann C, Weber C, Soehnlein O, Steffens S. The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment. EMBO Mol Med. 2016; 8:937-48. [Project A6, B5, A1, C1]
  • Silvestre-Roig C, Hidalgo A, Soehnlein O. Neutrophil heterogeneity: implications for homeostasis and pathogenesis. Blood. 2016; 127:2173-81. Review. [Project A6, B5]
  • Braster Q, Silvestre-Roig C, Hartwig H, Kusters P, Aarts S, den Toom M, Gallo RL, Weber C, Lutgens E, Soehnlein O. Cathelicidin regulates myeloid cell accumulation in adipose tissue and promotes insulin resistance during obesity. Thromb Haemost. 2016; 115:1237-9. [Project A5, A6, B5]
  • Wichapong K, Alard JE, Ortega-Gomez A, Weber C, Hackeng TM, Soehnlein O, Nicolaes GA. Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1). J Med Chem. 2016; 59:4289-301. [Project A6, B5]
  • Horckmans M, Ring L, Duchene J, Santovito D, Schloss MJ, Drechsler M, Weber C, Soehnlein O, Steffens S. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype. Eur Heart J. 2016 Feb 2. pii: ehw002. [Epub ahead of print] [Project A6, B5, A1, C1]
  • Gerdes N, Seijkens T, Lievens D, Kuijpers MJ, Winkels H, Projahn D, Hartwig H, Beckers L, Megens RT, Boon L, Noelle RJ, Soehnlein O, Heemskerk JW, Weber C, Lutgens E. Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes. Arterioscler Thromb Vasc Biol. 2016; 36:482-90. [Project A1, A5, A6, B5, Z1]
  • Hartmann P, Zhou Z, Natarelli L, Wei Y, Nazari-Jahantigh M, Zhu M, Grommes J, Steffens S, Weber C, Schober A. Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nature Communications 2016;7:10521. [Project A1, B4, C1]
  • Zahedi F, Nazari-Jahantigh M, Zhou Z, Subramanian P, Wei Y, Grommes J, Offermanns S, Steffens S, Weber C, Schober A. Dicer generates a microRNA regulatory network in smooth muscle cells during vascular repair that limits neointima formation. Cellular and Molecular Life Sciences, 2016, Sep 12. [Epub ahead of print] [Project A1, B4, C1]
  • Cabrera-Fuentes HA, Alba-Alba C, Aragones J, Bernhagen J, Boisvert WA, Bøtker HE, Cesarman-Maus G, Fleming I, Garcia-Dorado D, Lecour S, Liehn E, Marber MS, Marina N, Mayr M, Perez-Mendez O, Miura T, Ruiz-Meana M, Salinas-Estefanon EM, Ong SB, Schnittler HJ, Sanchez-Vega JT, Sumoza-Toledo A, Vogel CW, Yarullina D, Yellon DM, Preissner KT, Hausenloy DJ. Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside. Basic Res Cardiol. 2016; 111:7. [Project A3]
  • Pasqualon T, Lue H, Groening S, Pruessmeyer J, Jahr H, Denecke B, Bernhagen J, Ludwig A. Cell surface syndecan-1 contributes to binding and function of macro¬phage migration inhibitory factor (MIF) on epithelial tumor cells. Biochim Biophys Acta. 2016; 1863:717-726. [Project A3]
  • El Bounkari O, Bernhagen J. Discovery of a startling star: chemotaxis and chemotactic inhibition by starfish MIFs. Immunol Cell Biol. 2016; 94:313-314. [Project A3]
  • Roger T, Schneider A, Weier M, Sweep FC, Le Roy D, Bernhagen J, Calandra T, Giannoni E. High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates. Proc Natl Acad Sci U S A. 2016; 113:E997-1005. [Project A3]
  • Noels H, Bernhagen J. Editorial: The CXCR4 Ligand/Receptor Family and the DPP4 Protease in High-Risk Cardiovascular Patients. Front Immunol. 2016; 7:58. [Project A3]
  • Przybyl L, Haase N, Golic M, Rugor J, Solano ME, Arck PC, Gauster M, Huppertz B, Emontzpohl C, Stoppe C, Bernhagen J, Leng L, Bucala R, Schulz H, Heuser A, Weedon-Fekjær MS, Johnsen GM, Peetz D, Luft FC, Staff AC, Müller DN, Dechend R, Herse F. CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia. Circ Res. 2016; 119:55-68. [Project A3]
  • Rajasekaran D, Gröning S, Schmitz C, Zierow S, Drucker N, Bakou M, Kohl K, Mertens A, Lue H, Weber C, Xiao A, Luker G, Kapurniotu A, Lolis E, Bernhagen J. Macrophage migration inhibitory factor-CXCR4 receptor interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE. J Biol Chem. 2016; 291:15881-15895. [Project A1, A3]
  • Kim BS, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R. D-dopachrome tautomerase in adipose tissue inflammation and wound repair. J Cell Mol Med. 2016 Sep 7. [Project A3]
  • Cabrera-Fuentes HA, Aragones J, Bernhagen J, Boening A, Boisvert WA, Bøtker HE, Bulluck H, Cook S, Di Lisa F, Engel FB, Engelmann B, Ferrazzi F, Ferdinandy P, Fong A, Fleming I, Gnaiger E, Hernández-Reséndiz S, Kalkhoran SB, Kim MH, Lecour S, Liehn EA, Marber MS, Mayr M, Miura T, Ong SB, Peter K, Sedding D, Singh MK, Suleiman MS, Schnittler HJ, Schulz R, Shim W, Tello D, Vogel CW, Walker M, Li QO, Yellon DM, Hausenloy DJ, Preissner KT. From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research". Basic Res Cardiol. 2016; 111(6):69. [Project A3]
  • Koenen RR. The prowess of platelets in immunity and inflammation. Thromb Haemost 2016; 116: 605–12. [Project A2]
  • Bauer C, Kühnemuth B, Duewell P, Ormanns S, Gress T, Schnurr M. Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer. Cancer Lett. 2016; 381:259-68. Review. [B7]
  • Berchtold E, Csaba G, Zimmer R. Evaluating Transcription Factor Activity Changes by Scoring Unexplained Target Genes in Expression Data. PLoS One. 2016;11:e0164513. [Project Z2]
  • Pesch R, Zimmer R. Cross-species Conservation of context-specific networks. BMC Syst Biol. 2016;10:76. [Project Z2]
  • Schöppner P, Csaba G, Braun T, Daake M, Richter B, Lange OF, Zacharias M, Zimmer R, Haslbeck M. Regulatory Implications of Non-Trivial Splicing: Isoform 3 of Rab1A Shows Enhanced Basal Activity and Is Not Controlled by Accessory Proteins. J Mol Biol. 2016; 428:1544-57. [Project Z2]
  • Geistlinger L, Csaba G, Zimmer R. Bioconductor's EnrichmentBrowser: seamless navigation through combined results of set- & network-based enrichment analysis. BMC Bioinformatics. 2016;17:45. [Project Z2]
  • Srikakulapu P, Hu D, Yin C, Mohanta SK, Bontha SV, Peng L, Beer M, Weber C, McNamara CA, Grassia G, Maffia P, Manz RA, Habenicht AJ. Artery tertiary lymphoid organs control multilayered territorialized atherosclerosis b-cell responses in aged apoe-/- mice. Arterioscler Thromb Vasc Biol. 2016;36:1174-1185. [Project A1]
  • Weber C, Doring Y, Noels H. Potential cell-specific functions of cxcr4 in atherosclerosis. Hamostaseologie. 2016;36:97-102. [Project A1]
  • Stark K, Philippi V, Stockhausen S, Busse J, Antonelli A, Miller M, Schubert I, Hoseinpour P, Chandraratne S, von Brühl ML, Gärtner F, Lorenz M, Agresti A, Coletti R, Antoine DJ, Heermann R, Jung K, Reese S, Laitinen I, Schwaiger M, Walch A, Sperandio M, Nawroth PP, Reinhardt C, Jäckel S, Bianchi ME, Massberg S. Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice. Blood. 2016 Aug 29. [Project A7]
  • Meiler S, Smeets E, Winkels H, Shami A, Pascutti MF, Nolte MA, Beckers L, Weber C, Gerdes N, Lutgens E. Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T cell responses. Arterioscler Thromb Vasc Biol. 2016, 36:1748-52. [Project A5]
  • Jung C, Lichtenauer M, Strodthoff D, Winkels H, Wernly C, Bürger C, Kamchybekov U, Lutgens E, Figulla HR, Gerdes N. Alterations in systemic levels of Th1, Th2 and Th17 cytokines in overweight adolescents and obese mice. Pediatr Diabetes. 2016 Sep 6. doi: 10.1111/pedi.12435. [Project A5]
  • Jansen M, Hollander M, van Royen, N, Horrevoets AJ, Lutgens E. CD40 in coronary artery disease: a matter of macrophages? Basic Res Cardiol 2016; 111: 38, [Project A5]
  • van den Berg S, Seijkens TTP, Kusters PJH, Beckers L, den Toom M, Smeets E, Levels J, de Winther M, Lutgens E. Diet induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow. FASEB. 2016; 30: 1779-1788. [Project A5]
  • Schaftenaar F, Frodermann V, Kuiper J, Lutgens E. Atherosclerosis: the interplay between lipids and immune cells. Curr Opin Lipidol. 2016; 27:209-15. [Project A5]
  • Seeger M, Karlas A, Soliman D, Pelisek J, Ntziachristos V. Multimodal optoacoustic and multiphoton microscopy of human carotid atheroma. Photoacoustics 2016; 4:102-111. [Project Z1]
  • Wissmeyer G, Soliman D, Shnaiderman R, Rosenthal A, Ntziachristos V. All-optical optoacoustic microscope based on wideband pulse interferometry. Optics letters 41.9 2016; 41:1953-6. [Project Z1]
  • Jamasbi J, Megens RT, Bianchini M, Uhland K, Münch G, Ungerer M, Sherman S, Faussner A, Brandl R, John C, Buchner J, Weber C, Lorenz R, Elia N, Siess W. Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation. JACC Basic Transl Sci. 2016 Apr 25;1(131):142-13. [Project Z1, B8]
  • García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, Fernandez AM, Luquet S, Woods SC, Torres-Alemán I, Kahn CR, Götz M, Horvath TL, Tschöp MH. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. 2016; 166:867-80. [Project A4]
  • Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hofmann SM, Yang B, Tschöp MH*, DiMarchi R, Müller TD. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell. 2016; 167:843-857.e14. [Project A4, A1]
  • Mahl C, Egea V, Megens RT, Pitsch T, Santovito D, Weber C, Ries C. RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/β-catenin signaling in human mesenchymal stem cells. Cell Mol Life Sci. 2016; 73:1489-501. [Project A1, Z1]
  • Winkels H, Meiler S, Smeets E, Lievens D, Engel E, Spitz C, Bürger C, Rinne P, Beckers L, Dandl A, Reim S, Ahmadsei M, Van den Bossche J, Holdt LM, Megens RTA, Schmitt MM, de Winther M, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N. CD70 limits atherosclerosis and promotes macrophage function. Thromb Haemost, in press. [Project A5, Z1, A1]
  • Pfeiler S, Khandagale AB, Magenau A, Nichols M, Heijnen HF, Rinninger F, Ziegler T, Seveau S, Schubert S, Zahler S, Verschoor A, Latz E, Massberg S, Gaus K, Engelmann B. Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI. Sci Rep. 2016; 6:34440. [Project B6, A7, B7]
  • Pfeiler S, Stark K, Massberg S, Engelmann B. Propagation of thrombosis by neutrophils and extracellular nucleosome networks. Haematologica (in press). [Project A7, B6]
  • Cabrera-Fuentes HA, Aragones J, Bernhagen J, Boening A, Boisvert WA, Bøtker HE, Bulluck H, Cook S, Di Lisa F, Engel FB, Engelmann B, Ferrazzi F, Ferdinandy P, Fong A, Fleming I, Gnaiger E, Hernández-Reséndiz S, Kalkhoran SB, Kim MH, Lecour S, Liehn EA, Marber MS, Mayr M, Miura T, Ong SB, Peter K, Sedding D, Singh MK, Suleiman MS, Schnittler HJ, Schulz R, Shim W, Tello D, Vogel CW, Walker M, Li QO, Yellon DM, Hausenloy DJ, Preissner KT. From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research". Basic Res Cardiol. 2016; 111: 69. [Project B6]
  • Schober A, Weber C. Mechanisms of MicroRNAs in Atherosclerosis. Annu Rev Pathol. 2016;11:583-616. [Project A1, B4, B8]
  • Wei Y, Schober A. MicroRNA regulation of macrophages in human pathologies. Cell Mol Life Sci. 2016;73:3473-95. [Project B4, B8]

 
2015

  •  Wobst J, Rumpf PM, Dang TA, Segura-Puimedon M, Erdmann J, Schunkert H. Molecular variants of soluble guanylyl cyclase affecting cardiovascular risk. Circ J, 2015; 79:463-9. [Project B2]
  • Alard JE, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RT, Leoni G, Ferraro B, Rossaint J, Paulin N, Ng J, Ippel H, Suylen D, Hinkel R, Blanchet X, Gaillard F, D'Amico M, von Hundelshausen P, Zarbock A, Scheiermann C, Hackeng TM, Steffens S, Kupatt C, Nicolaes GA, Weber C, Soehnlein O. Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. Sci Transl Med.;7:317ra196.[Project A1, A6, B5, Z1]
  • Hartwig H, Silvestre-Roig C, Hendrikse J, Beckers L, Paulin N, Van der Heiden K, Braster Q, Drechsler M, Daemen MJ, Lutgens E, Soehnlein O. Atherosclerotic Plaque Destabilization in Mice: A Comparative Study. PLoS One. 2015;10:e0141019. [Project A5, A6, B5]
  • Klapproth S, Sperandio M, Pinheiro EM, Prünster M, Soehnlein O, Gertler FB, Fässler R, Moser M. Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice. Blood. 2015;126:2704-12. [Project A6, A8, A9, B5]
  • Soehnlein O, Ortega-Gómez A, Döring Y, Weber C. Neutrophil-macrophage interplay in atherosclerosis: protease-mediated cytokine processing versus NET release. Thromb Haemost. 2015;114:866-7. [Project A6, B5]
  • Mandl M, Drechsler M, Jansen Y, Neideck C, Noels H, Faussner A, Soehnlein O, Weber C, Döring Y. Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation. PLoS One. 2015;10:e0134176. [Project A1, A6, B5]
  • Medina I, Cougoule C, Drechsler M, Bermudez B, Koenen RR, Sluimer J, Wolfs I, Döring Y, Herias V, Gijbels M, Bot I, de Jager SC, Weber C, Cleutjens J, van Berkel TJ, Sikkink KJ, Mócsai A, Maridonneau-Parini I, Soehnlein O, Biessen EA. Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility. Circulation. 2015;132:490-501. [Project A6, B5]
  • Viola J, Soehnlein O. Atherosclerosis - A matter of unresolved inflammation. Semin Immunol. 2015;27:184-93. Review. [Project A6, B5]
  • Drechsler M, Duchene J, Soehnlein O. Chemokines control mobilization, recruitment, and fate of monocytes in atherosclerosis. Arterioscler Thromb Vasc Biol. 201;35:1050-5. Review. [Project A6, B5]
  • Zarzycka B, Seijkens T, Nabuurs SB, Ritschel T, Grommes J, Soehnlein O, Schrijver R, van Tiel CM, Hackeng TM, Weber C, Giehler F, Kieser A, Lutgens E, Vriend G, Nicolaes GA. Discovery of small molecule CD40-TRAF6 inhibitors. J Chem Inf Model. 2015;55:294-307. [Project A1, A5, A6, B5]
  • Drechsler M, de Jong R, Rossaint J, Viola JR, Leoni G, Wang JM, Grommes J, Hinkel R, Kupatt C, Weber C, Döring Y, Zarbock A, Soehnlein O. Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment. Circ Res. 2015;116:827-35. [Project A6, B5]
  • Karshovska E, Zhao Z, Blanchet X, Schmitt MM, Bidzhekov K, Soehnlein O, von Hundelshausen P, Mattheij NJ, Cosemans JM, Megens RT, Koeppel TA, Schober A, Hackeng TM, Weber C, Koenen RR. Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice. Circ Res. 2015;116:587-99. [Project A1, A2, A5, B6, Z1]
  • Hartwig H, Silvestre Roig C, Daemen M, Lutgens E, Soehnlein O. Neutrophils in atherosclerosis. A brief overview. Hamostaseologie. 2015;35:121-7. Review. [Project A5, A6, B5]
  • Döring Y. Not growth but death: GM-CSF/IL-23 axis drives atherosclerotic plaque vulnerability by enhancing macrophage and DC apoptosis. Circ Res. 2015;116:222-4. [Project B5, A1]
  • Döring Y, Drechsler M, Soehnlein O, Weber C. Neutrophils in atherosclerosis: from mice to man. Arterioscler Thromb Vasc Biol. 2015;35:288-95. Review. [Project A1, A6, B5]
  • Pawig L, Klasen C, Weber C, Bernhagen J, Noels H. Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives Front Immunol. 2015;6:429. [Project A1, A3]
  • Panstruga R, Baumgarten K, Bernhagen J. Phylogeny and evolution of plant macrophage migration inhibitory factor/D-dopachrome tautomerase-like proteins. BMC Evol Biol. 2015;15:64. [Project A3]
  • Dickerhof N, Schindler L, Bernhagen J, Kettle AJ, Hampton MB. Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myelo¬peroxidase-derived oxidants but retains its immunomodulatory function. Free Radic Biol Med. 2015;89:498-511. [Project A3]
  • Stoppe C, Rex S, Goetzenich A, Kraemer S, Emontzpohl C, Soppert J, Averdunk L, Sun Y, Rossaint R, Lue H, Huang C, Song Y, Pantouris G, Lolis E, Leng L, Schulte W, Bucala R, Weber C, Bernhagen J. Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients. Antioxid Redox Signal. 2015; 23:865-879. [Project A1, A3]
  • Alampour-Rajabi S, El Bounkari O, Rot A, Müller-Newen G, Bachelerie F, Gawaz M, Weber C, Schober A, Bernhagen J. MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis. FASEB J. 2015;29:4497-4511. [Project A1, A3, B4, B8]
  • Vajen T, Mause SF, Koenen RR. Microvesicles from platelets: novel drivers of vascular inflammation. Thromb Haemost 2015; 114: 228–36. [Project A1, A3, B4]
  • Koenen RR. Neutrophil Extracellular Traps as Therapeutic Targets for Inflammatory Disease. American Journal of Pharmacology and Toxicology 2015; 1–3. [Project A2]
  • Erhard F, Zimmer R. Count ratio model reveals bias affecting NGS fold changes. Nucleic Acids Res. 2015;43:e136. [Project Z2]
  • Hu D, Mohanta SK, Yin C, Peng L, Ma Z, Srikakulapu P, Grassia G, MacRitchie N, Dever G, Gordon P, Burton FL, Ialenti A, Sabir SR, McInnes IB, Brewer JM, Garside P, Weber C, Lehmann T, Teupser D, Habenicht L, Beer M, Grabner R, Maffia P, Weih F, Habenicht AJ. Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin beta receptors. Immunity. 2015;42:1100-1115. [Project A1, B1]
  • von Hundelshausen P, Oexle K, Bidzhekov K, Schmitt MM, Hristov M, Blanchet X, Kaemmerer H, Matyas G, Meitinger T, Weber C. Recurrent spontaneous coronary dissections in a patient with a de novo fibrillin-1 mutation without marfan syndrome. Thromb Haemost. 2015;113:668-670. [Project A1, A2]
  • Hristov M, Weber C. Myocardial infarction and inflammation: Lost in the biomarker labyrinth. Circ Res. 2015;116:781-783. [Project A1]
  • Megens RT, Bianchini M, Schmitt MM, Weber C. Optical imaging innovations for atherosclerosis research: Multiphoton microscopy and optical nanoscopy. Arterioscler Thromb Vasc Biol. 2015;35:1339-1346. [Project A1, Z1]
  • Santovito D, Egea V, Weber C. Small but smart: Micrornas orchestrate atherosclerosis development and progression. Biochim Biophys Acta. 2015. [Project A1, B4]
  • van der Vorst EP, Doring Y, Weber C. Chemokines. Arterioscler Thromb Vasc Biol. 2015;35:e52-56. [Project A1]
  • van der Vorst EP, Doring Y, Weber C. Mif and cxcl12 in cardiovascular diseases: Functional differences and similarities. Front Immunol. 2015;6:373. [Project A1]
  • van der Vorst EP, Doring Y, Weber C. Chemokines and their receptors in atherosclerosis. J Mol Med (Berl). 2015;93:963-971.[Project A1]
  • Zirlik A, Lutgens E. An inflammatory link in atherosclerosis and obesity. Co-stimulatory molecules.Hamostaseologie. 2015;35:272-8. [Project A5]
  • Bäck M, Weber C, Lutgens E. Regulation of atherosclerotic plaque inflammation. J Intern Med. 2015 Nov;278(5):462-82. [Project A5]
  • van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond). 2015 39:782-90. [Project A5]
  • Azghandi S, Prell C, van der Laan S, Schneider M, Malik R, Berer K, Gerdes N, Pasterkamp G, Weber C, Haffner C, Dichgans M. Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1. Stroke. 2015, 46(1):197-202. [Project B3, A5]
  • Jamasbi J, Megens RT, Bianchini M, Münch G, Ungerer M, Faussner A, Sherman S, Walker A, Goyal P, Jung S, Brandl R, Weber C, Lorenz R, Farndale R, Elia N, Siess W. Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies. J Am Coll Cardiol. 2015; 65:2404-15. [Project Z1, B8]
  • Holdt LM, Teupser D. Long noncoding RNA-MicroRNA pathway controlling nuclear factor IA, a novel atherosclerosis modifier gene. Arterioscler Thromb Vasc Biol. 2015; 35:7-8. [Project B1]
  • Megens RTA, Soehnlein O. Intravital microscopy for atherosclerosis research: Methods in Mouse Atherosclerosis. Methods Mol Biol. 2015;1339:41-6. [Project A6, B5, Z1]
  • Schober A, Nazari-Jahantigh M, Weber C. MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis. Nat Rev Cardiol. 2015;12:361-374. [Project A1, B4, B8]
  • Akhtar S, Hartmann P, Karshovska E, Rinderknecht F-A, Subramanian P, Gremse F, Grommes J, Jacobs M, Kiessling F, Weber C, Steffens S, Schober A. Endothelial Hypoxia-Inducible Factor-1 alpha Promotes Atherosclerosis and Monocyte Recruitment by Upregulating MicroRNA-19a. Hypertension. 2015;66:1220-1226. [Project A1, B, B5, C1]

2014

  • Kapopara PR, von Felden J, Soehnlein O, Wang Y, Napp LC, Sonnenschein K, Wollert KC, Schieffer B, Gaestel M, Bauersachs J, Bavendiek U. Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodelling and promotes endothelial healing after arterial injury. Thromb Haemost. 2014;112:1264-76. [Project A6, B5]
  • Noels H, Zhou B, Tilstam PV, Theelen W, Li X, Pawig L, Schmitz C, Akhtar S, Simsekyilmaz S, Shagdarsuren E, Schober A, Adams RH, Bernhagen J, Liehn EA, Doring Y, Weber C. Deficiency of endothelial cxcr4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol. 2014;34:1209-1220. [Project A1]
  • Doring Y, Pawig L, Weber C, Noels H. The cxcl12/cxcr4 chemokine ligand/receptor axis in cardiovascular disease. Front Physiol. 2014;5:212. [Project A1, B5]