Publications 2024

Adam S, Maas SL, Huchzermeier R, Rakateli L, Abschlag K, Hohl M, Liao L, Bartneck M, Teunissen M, Wouters K, Santovito D, Jankowski J, Biessen EAL, van der Vorst EPC. The calcium-sensing-receptor (CaSR) in adipocytes contributes to sex-differences in the susceptibility to high fat diet induced obesity and atherosclerosis. EBioMedicine. 2024 Sep;107:105293. PMID: 39146692

Brunetta HS, Jung AS, Valdivieso-Rivera F, de Campos Zani SC, Guerra J, Furino VO, Francisco A, Berçot M, Moraes-Vieira PM, Keipert S, Jastroch M, Martinez LO, Sponton CH, Castilho RF, Mori MA, Bartelt A. IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat. EMBO J. 2024 Nov;43(21):4870-4891. PMID: 39284909

Cao J, Roth S, Zhang S, Kopczak A, Mami S, Asare Y, Georgakis MK, Messerer D, Horn A, Shemer R, Jacqmarcq C, Picot A, Green JP, Schlegl C, Li X, Tomas L, Dutsch A, Liman TG, Endres M, Wernsdorf SR, Fürle C, Carofiglio O, Zhu J, Brough D; DEMDAS Study Group; Hornung V, Dichgans M, Vivien D, Schulz C, Dor Y, Tiedt S, Sager HB, Grosse GM, Liesz A (2024) DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature 633:433-441. PMID: 39112714

Döring Y, Bender A, Soehnlein O. Lack of Formyl-peptide Receptor 1 Mitigates Atherosclerosis in Hyperlipidemic Mice. Thromb Haemost. 2024 Oct;124(10):986-989. PMID: 38782024

Döring Y, van der Vorst EPC, Weber C. Targeting immune cell recruitment in atherosclerosis. Nat Rev Cardiol. 2024 Nov;21(11):824-840. PMID: 38664575

Döring Y, van der Vorst EPC, Yan Y, Neideck C, Blanchet X, Jansen Y, Kemmerich M, Bayasgalan S, Peters LJF, Hristov M, Bidzhekov K, Yin C, Zhang X, Leberzammer J, Li Y, Park I, Kral M, Nitz K, Parma L, Gencer S, Habenicht A, Faussner A, Teupser D, Monaco C, Holdt L, Megens RTA, Atzler D, Santovito D, von Hundelshausen P, Weber C (2024) Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis. Nat Cardiovasc Res 3:221-242. PMID: 39044999

Frenz-Wiessner S, Fairley SD, Buser M, Goek I, Salewskij K, Jonsson G, Illig D, Zu Putlitz B, Petersheim D, Li Y, Chen PH, Kalauz M, Conca R, Sterr M, Geuder J, Mizoguchi Y, Megens RTA, Linder MI, Kotlarz D, Rudelius M, Penninger JM, Marr C, Klein C. Generation of complex bone marrow organoids from human induced pluripotent stem cells. Nat Methods. 2024 May;21(5):868-881. PMID: 38374263

Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, van den Heuvel D, Belz L, Sobirova G, Zhang Z, Titova A, Navarro AM, Pekayvaz K, Lorenz M, von Baumgarten L, Kranich J, Straub T, Popper B, Zheden V, Kaufmann WA, Guo C, Piontek G, von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Brocker T, Walzog B, Scheiermann C, Aird WC, Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt M, Hauschild R, Rudelius M, Oostendorp RAJ, Iannacone M, Heinig M, Massberg S (2024) Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. Nature 631:645-653. PMID: 38987596

Guerra J, Matta L, Bartelt A. Cardiac proteostasis in obesity and cardiovascular disease. Herz. 2024 Mar;49(2):118-123. PMID: 38329532

Hristov M, Weber C. Monocyte Subsets in Cardiovascular Disease: A Biomarker Perspective. Thromb Haemost. 2024 Jul 6. PMID: 38897222

Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Bartelt A, Jastroch M, Wachten D, Kornfeld JW. Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function. Nat Metab. 2024 Jun;6(6):1053-1075. PMID: 38684889

Klingelhuber F, Frendo-Cumbo S, Omar-Hmeadi M, Massier L, Kakimoto P, Taylor AJ, Couchet M, Ribicic S, Wabitsch M, Messias AC, Iuso A, Müller TD, Rydén M, Mejhert N, Krahmer N. A spatiotemporal proteomic map of human adipogenesis. Nat Metab. 2024 May;6(5):861-879. PMID: 38565923

Kral, M., Döring, Y. & Weber, C. Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control. Sig Transduct Target Ther 9, 313 (2024). doi: 10.1038/s41392-024-02032-7

Kral M, van der Vorst EPC, Weber C and Döring Y (2024) (Multi-) omics studies of ILC2s in inflammation and metabolic diseases. Front. Cell Dev. Biol. 12:1473616. doi: 10.3389/fcell.2024.1473616

Malik R, Beaufort N, Li J, Tanaka K, Georgakis MK, He Y, Koido M, Terao C, Japan B, Anderson CD, Kamatani Y, Zand R, Dichgans M (2024) Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease. Nat Cardiovasc Res 3:701-713. PMID: 39196222

Mohanta SK, Santovito D, Weber C. Cortico-limbic restructuring and atherosclerosis: a stressful liaison. Eur Heart J. 2024 May 21;45(19):1765-1767. PMID: 38770964

Möller-Ramon Z, Aslani M, Sobczak N, Hristov M, Weber C, Rot A, Duchêne J. The 129 strain-derived passenger mutations in ACKR1-deficient mice alter the expression of PYHIN and Fc-gamma receptor genes. J Leukoc Biol. 2024 Sep 25:qiae208. PMID: 39319406

Mueller TT, Pilartz M, Thakur M, LangHeinrich T, Luo J, Block R, Hoeflinger JKL, Meister S, Karaj F, Perez LG, Öllinger R, Engleitner T, Thoss J, Voelkl M, Tersteeg C, Koedel U, Kohlmaier AZ, Teupser D, Wygrecka M, Ye H, Preissner KT, Radbruch H, Elezkurtaj S, Mack M, Von Hundelshausen P, Weber C, Massberg S, Schulz C, Rad R, Huber S, Ishikawa-Ankerhold H, Engelmann B. Mutual regulation of CD4+ T cells and intravascular fibrin in infections. Haematologica. 2024 Aug 1;109(8):2487-2499. PMID: 38572559

Ofoghi A, Kotschi S, Lemmer IL, Haas DT, Willemsen N, Bayer B, Jung AS, Möller S, Haberecht-Müller S, Krüger E, Krahmer N, Bartelt A. Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis. Cell Death Differ. 2024 Oct 9. PMID: 39384955

Parma L, Duchene J, Weber C. Breaking Point: How Intraplaque Hemorrhage Propels Plaque Rupture. Circ Res. 2024 Jul 5;135(2):317-319. PMID: 38963871

Pajonczyk D, Sternschulte MF, Soehnlein O, Bermudez M, Raabe CA, Rescher U. Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles. Br J Pharmacol. 2024 Sep 18. PMID: 39294930.

Pekayvaz K, Losert C, Knottenberg V, Gold C, van Blokland I, Oelen R, Groot HE, Benjamins J, Brambs S, Kaiser R, Gottschlich A, Hoff-mann GV, Eivers L, Martinez-Navarro A, Bruns N, Stiller S, Akgöl S, Yue K, Polewka V, Escaig R, Joppich M, Janjic A, Popp O, Kobold S, Petzold T, Zimmer R, Enard W, Saar K, Mertins P, Huebner N, van der Harst P, Franke L, van der Wijst M, Massberg S, Heinig M, Nicolai L, Stark K (2024) Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes. Nat Med 30:1696-1710. PMID: 38773340

Prapiadou S, Živković L, Thorand B, George M, van der Laan S, Malik R, Herder C, Koenig W, Ueland T, Kleveland O, Aukrust P, Gullestad L, Bernhagen J, Pasterkamp G, Peters A, Hingorani AD, Rosand J, Dichgans M, Anderson CD, Georgakis MK (2024) Proteogeno-mic data integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis. Circulation 149:669-683. PMID: 38152968

Santovito D, Henderson J, Bidzhekov K, Triantafyllidou V, Jansen Y, Chen Z, Farina F, Diagel A, Aslani M, Blanchet X, Schunkert H, Megens RTA, Döring Y, Sattler M, Weber C (2024) Mex3a protects against atherosclerosis: evidence from mice and humans. Circulation 150:1213-1216. PMID: 39374329

Schopohl B, Kohlhaas M, Nickel AG, Schiuma AF, Maas SL, van der Vorst EPC, Shia YX, Maack C, Steffens S, Puhl SL. Gpr55 deficiency crucially alters cardiomyocyte homeostasis and counteracts angiotensin II induced maladaption in female mice. Br J Pharmacol. 2024 Oct 20. PMID: 39428581

Steffens S, Schröder K, Krüger M, Maack C, Streckfuss-Bömeke K, Backs J, Backofen R, Baeßler B, Devaux Y, Gilsbach R, Heijman J, Knaus J, Kramann R, Linz D, Lister AL, Maatz H, Maegdefessel L, Mayr M, Meder B, Nussbeck SY, Rog-Zielinska EA, Schulz MH, Sickmann A, Yigit G, Kohl P. The challenges of research data management in cardiovascular science: a DGK and DZHK position paper-executive summary. Clin Res Cardiol. 2024 May;113(5):672-679. PMID: 37847314

Takaoka M, Zhao X, Lim H, Magnussen C, Ang O, Suffee N, Schrank P, Ong W, Tsiantoulas D, Sommer F, Mohanta SK, Harrison J, Meng Y, Laurans L, Wu F, Lu Y, Masters L, Newland S, Denti L, Hong M, Chajadine M, Juonala M, Koskinen J, Kähönen M, Pahkala K, Rovio S, Mykkänen J, Thomson R, Kaisho T, Habenicht A, Clement M, Tedgui A, Ait-Oufella H, Zhao T, Nus M, Ruhrberg C, Taleb S, Williams J, Rai-takari O, Angeli V, Mallat Z (2024) Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis. Nature 634:457-65. PMID: 39231480

Vos WG, van Os BW, den Toom M, Beckers L, van Roomen CPAA, van Tiel CM, Mohapatra BC, Band H, Nitz K, Weber C, Atzler D, de Winther MPJ, Bosmans LA, Lutgens E, Seijkens TTP. T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation. Front Immunol. 2024 Mar 4;15:1297893. PMID: 38504977

Wang Y, Li G, Chen B, Shakir G, Volz M, van der Vorst EPC, Maas SL, Geiger M, Jethwa C, Bartelt A, Li Z, Wettich J, Sachs N, Maegdefessel L, Nazari Jahantigh M, Hristov M, Lacy M, Lutz B, Weber C, Herzig S, Guillamat Prats R, Steffens S. Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner. Cardiovasc Res. 2024 Oct 14;120(12):1411-1426. PMID: 38838211

Windisch R, Soliman S, Hoffmann A, Chen-Wichmann L, Danese A, Vosberg S, Bravo J, Lutz S, Kellner C, Fischer A, Gebhard C, Redondo Monte E, Hartmann L, Schneider S, Beier F, Strobl CD, Weigert O, Peipp M, Schündeln M, Stricker SH, Rehli M, Bernhagen J, Humpe A, Klump H, Brendel C, Krause DS, Greif PA, Wichmann C. Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2312499121. PMID: 38857395

Zhang L, Woltering I, Holzner M, Brandhofer M, Schaefer CC, Bushati G, Ebert S, Yang B, Muenchhoff M, Hellmuth JC, Scherer C, Wichmann C, Effinger D, Hübner M, El Bounkari O, Scheiermann P, Bernhagen J, Hoffmann A. CD74 is a functional MIF receptor on activated CD4+ T cells. Cell Mol Life Sci. 2024 Jul 11;81(1):296. PMID: 38992165