Publications 2023

Asare Y, Stoppe C, Bernhagen J. Tracing the failing heart: dual genetic fate mapping for target identification. Signal Transduct Target Ther. 2023 Aug 4;8(1):287. PMID: 37537182

Bianchini M, Moller-Ramon Z, Weber C, Megens RTA, Duchene J (2023) Short-Term Western Diet Causes Rapid and Lasting Alterations of Bone Marrow Physiology. Thromb Haemost. PMID 37549687

Blanchet X, Weber C, von Hundelshausen P (2023) Chemokine Heteromers and Their Impact on Cellular Function-A Conceptual Framework. Int J Mol Sci; 24(13). PMID 37446102

Bonfiglio CA, Weber C, Atzler D, Lutgens E (2023) Immunotherapy and cardiovascular diseases: novel avenues for immunotherapeutic approaches. QJM; 116(4): 271-8. PMID 34293177

Bosmans LA, van Tiel CM, Aarts SABM, Willemsen L, Baardman J, van Os BW, Toom MD, Beckers L, Ahern DJ, Levels JHM, Jongejan A, Moerland PD, Verberk SGS, den Bossche JV, de Winther MMPJ, Weber C, Atzler D, Monaco C, Gerdes N, Shami A, Lutgens E. Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state. Cardiovasc Res. 2023 May 22;119(5):1146-1160. PMID: 35587037

Brandhofer M, Hoffmann A, Blanchet X, Siminkovitch E, Rohlfing AK, El Bounkari O, Nestele JA, Bild A, Kontos C, Hille K, Rohde V, Fröhlich A, Golemi J, Gokce O, Krammer C, Scheiermann P, Tsilimparis N, Sachs N, Kempf WE, Maegdefessel L, Otabil MK, Megens RTA, Ippel H, Koenen RR, Luo J, Engelmann B, Mayo KH, Gawaz M, Kapurniotu A, Weber C, von Hundelshausen P, Bernhagen J. Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Cell Mol Life Sci. 2022 Sep 12;79(10):512. PMID: 36094626

Breidung D, Megas IF, Freytag DL, Bernhagen J, Grieb G. The Role of Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (D-DT/MIF-2) in Infections: A Clinical Perspective. Biomedicines. 2023 Dec 19;12(1):2. PMID: 38275363

Cimen I, Natarelli L, Abedi Kichi Z, Henderson JM, Farina FM, Briem E, Aslani M, Megens RTA, Jansen Y, Mann-Fallenbuchel E, Gencer S, Duchêne J, Nazari-Jahantigh M, van der Vorst EPC, Enard W, Döring Y, Schober A, Santovito D, Weber C (2023) Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice. Sci Transl Med 15:eadf3357. PMID: 37910599

Ebert S, Zang L, Ismail N, Otabil M, Frohlich A, Egea V, Acs S, Hoeberg M, Berres ML, Weber C, Moreira JMA, Ries C, Bernhagen J, El Bounkari O (2023) Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation. Cells; 12(14). PMID 37508563

Egea V, Megens RTA, Santovito D, Wantha S, Brandl R, Siess W, Khani S, Soehnlein O, Bartelt A, Weber C, Ries C (2023) Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques. Cardiovasc Res; 119(1): 155-66. PMID 35238350

Farina FM, Weber C, Santovito D (2023) The emerging landscape of non-conventional RNA functions in atherosclerosis. Atherosclerosis; 374: 74-86. PMID 36725418

Ferraro B, Giustetto P, Schengel O, Weckbach LT, Maegdefessel L, Soehnlein O (2023) Longitudinal In Vivo Monitoring of Atheroprogression in Hypercholesterolemic Mice Using Photoacoustic Imaging. Thromb Haemost; 123(5): 545-54. PMID 36596447

Giroud M, Kotschi S, Kwon Y, Le Thuc O, Hoffmann A, Gil-Lozano M, Karbiener M, Higareda-Almaraz JC, Khani S, Tews D, Fischer-Posovszky P, Sun W, Dong H, Ghosh A, Wolfrum C, Wabitsch M, Virtanen KA, Blüher M, Nielsen S, Zeigerer A, García-Cáceres C, Scheideler M, Herzig S, Bartelt A. The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes. EMBO Rep. 2023 Oct 9;24(10):e57600. PMID: 37671834

Guillamat-Prats R, Hering D, Derle A, Rami M, Härdtner C, Santovito D, Rinne P, Bindila L, Hristov M, Pagano S, Vuilleumier N, Schmid S, Janjic A, Enard W, Weber C, Maegdefessel L, Faussner A, Hilgendorf I, Steffens S (2022) GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation. Nat Cardiovasc Res 1:1056-1071. PMID: 36523570

Kocberber Z, Willemsen N, Bartelt A (2023) The role of proteasome activators PA28alphabeta and PA200 in brown adipocyte differentiation and function. Front Endocrinol (Lausanne); 14: 1176733. PMID 37201100

Krammer C, Yang B, Reichl S, Besson-Girard S, Ji H, Bolini V, Schulte C, Noels H, Schlepckow K, Jocher G, Werner G, Willem M, El Bounkari O, Kapurniotu A, Gokce O, Weber C, Mohanta S, Bernhagen J (2023) Pathways linking aging and atheroprotection in Mif-deficient atherosclerotic mice. FASEB J; 37(3): e22752. PMID 36794636

Maas SL, Megens RTA, van der Vorst EPC (2023) Ex Vivo Perfusion System to Analyze Chemokine-Driven Leukocyte Adhesion. Methods Mol Biol; 2597: 59-75. PMID 36374414

Mohanta SK, Yin C, Weber C, Godinho-Silva C, Veiga-Fernandes H, Xu QJ, Chang RB, Habenicht AJR (2023) Cardiovascular Brain Circuits. Circ Res; 132(11): 1546-65. PMID 37228235

Mohanta SK, Yin C, Weber C, Habenicht AJR (2023) Neuroimmune cardiovascular interfaces in atherosclerosis. Front Cell Dev Biol; 11: 1117368. PMID 36793445

Müller GA, Müller TD. Transfer of Proteins from Cultured Human Adipose to Blood Cells and Induction of Anabolic Phenotype Are Controlled by Serum, Insulin and Sulfonylurea Drugs. Int J Mol Sci. 2023 Mar 2;24(5):4825.  PMID: 36902257

Pan C, Herrero-Fernandez B, Borja Almarcha C, Gomez Bris R, Zorita V, Saez A, Maas SL, Perez-Olivares L, Herrero-Cervera A, Lemnitzer P, van Avondt K, Silvestre-Roig C, Gonzalez-Granado JM, Chevre R, Soehnlein O (2023) Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic Mice. Circulation; 147(9): 774-7. PMID 36848415

Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionisio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K (2023) Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity; 56(10): 2325-41 e15. PMID 37652021

Rega S, Farina F, Bouhuis S, de Donato S, Chiesa M, Poggio P, Cavallotti L, Bonalumi G, Giambuzzi I, Pompilio G, Perrucci GL (2023) Multi-omics in thoracic aortic aneurysm: the complex road to the simplification. Cell Biosci; 13(1): 131. PMID 37475058

Reiche ME, Poels K, Bosmans LA, Vos WG, Van Tiel CM, Gijbels MJJ, Aarts S, Den Toom M, Beckers L, Weber C, Atzler D, Rensen PCN, Kooijman S, Lutgens E (2023) Adipocytes control hematopoiesis and inflammation through CD40 signaling. Haematologica; 108(7): 1873-85. PMID 36475519

Sachs S, Gotz A, Finan B, Feuchtinger A, DiMarchi RD, Doring Y, Weber C, Tschop MH, Muller TD, Hofmann SM (2023) GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease. Cardiovasc Diabetol; 22(1): 217. PMID 37592302

Santovito D, Steffens S, Barachini S, Madonna R (2023) Autophagy, innate immunity, and cardiac disease. Front Cell Dev Biol; 11: 1149409. PMID 37234771

Sharifi MA, Wierer M, Dang TA, Milic J, Moggio A, Sachs N, von Scheidt M, Hinterdobler J, Müller P, Werner J, Stiller B, Aherrahrou Z, Erdmann J, Zaliani A, Graettinger M, Reinshagen J, Gul S, Gribbon P, Maegdefessel L, Bernhagen J, Sager HB, Mann M, Schunkert H, Kessler T (2023) ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1. Circ Res 133:674-686. PMID: 37675562

Thavayogarajah T, Sinitski D, El Bounkari O, Torres-Garcia L, Lewinsky H, Harjung A, Chen HR, Panse J, Vankann L, Shachar I, Bernhagen J, Koschmieder S. CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia. Exp Hematol. 2022 Nov;115:30-43. PMID: 36096455

Tian Y, Milic J, Monasor LS, Chakraborty R, Wang S, Yuan Y, Asare Y, Behrends C, Tahirovic S, Bernhagen J. The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model. Cell Mol Life Sci. 2023 Aug 19;80(9):262. PMID: 37597109

van der Vorst EPC, Maas SL, Theodorou K, Peters LJF, Jin H, Rademakers T, Gijbels MJ, Rousch M, Jansen Y, Weber C, Lehrke M, Lebherz C, Yildiz D, Ludwig A, Bentzon JF, Biessen EAL, Donners M (2023) Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice. Front Cardiovasc Med; 10: 974918. PMID 36776254

van Os BW, Vos WG, Bosmans LA, van Tiel CM, Lith SC, den Toom MS, Beckers L, Levels JHM, van Wouw SAE, Zelcer N, Zaal EA, Berkers CR, van der Lest CHA, Helms JB, Weber C, Atzler D, de Winther MPJ, Baardman J, Lutgens E (2023) Hyperlipidaemia elicits an atypical, T helper 1-like CD4(+) T-cell response: a key role for very low-density lipoprotein. Eur Heart J Open; 3(2): oead013. PMID 36969380

Wagner JUG, Tombor LS, Malacarne PF, Kettenhausen LM, Panthel J, Kujundzic H, Manickam N, Schmitz K, Cipca M, Stilz KA, Fischer A, Muhly-Reinholz M, Abplanalp WT, John D, Mohanta SK, Weber C, Habenicht AJR, Buchmann GK, Angendohr S, Amin E, Scherschel K, Klocker N, Kelm M, Schuttler D, Clauss S, Gunther S, Boettger T, Braun T, Bar C, Pham MD, Krishnan J, Hille S, Muller OJ, Bozoglu T, Kupatt C, Nardini E, Osmanagic-Myers S, Meyer C, Zeiher AM, Brandes RP, Luxan G, Dimmeler S (2023) Aging impairs the neurovascular interface in the heart. Science; 381(6660): 897-906. PMID 37616346

Wang Z, Zhang X, Lu S, Zhang C, Ma Z, Su R, Li Y, Sun T, Li Y, Hong M, Deng X, Monjezi MR, Hristov M, Steffens S, Santovito D, Dornmair K, Ley K, Weber C, Mohanta SK, Habenicht AJR, Yin C (2023) Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis. Nat Cardiovasc Res; 2(3): 290-306. PMID 37621765

Weber C, Blanchet X, Lip GYH (2023) Thrombosis and Haemostasis 2022 Editors' Choice Papers. Thromb Haemost; 123(1): 123-30. PMID 36626900

Weber C, Habenicht AJR, von Hundelshausen P (2023) Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond. Eur Heart J; 44(29): 2672-81. PMID 37210082

Zhou Y, Schober A (2023) The Year of miR-223: How Platelets Can Kill Cardiomyocytes. Arterioscler Thromb Vasc Biol; 43(2): 231-3. PMID 36579642

Ziegler KA, Ahles A, Dueck A, Esfandyari D, Pichler P, Weber K, Kotschi S, Bartelt A, Sinicina I, Graw M, Leonhardt H, Weckbach LT, Massberg S, Schifferer M, Simons M, Hoeher L, Luo J, Erturk A, Schiattarella GG, Sassi Y, Misgeld T, Engelhardt S (2023) Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease. Science; 381(6655): 285-90. PMID 37471539