Publications 2019
Aarts S, Reiche M, den Toom M, Gijbels M, Beckers L, Gerdes N, Lutgens E (2019). Depletion of CD40 on CD11c(+) cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH. Sci Rep. 9:14702. PMID 31604965. [A5]
Aarts SA, Seijkens TT, Kusters PJ, van Tiel CM, Reiche ME, den Toom M, Beckers L, van Roomen CP, de Winther MP, Kooij G, Lutgens E (2019). Macrophage CD40-signaling drives experimental autoimmune encephalomyelitis. J Pathol. 247:471-480. PMID 30471110. [A5]
Adrover JM, Del Fresno C, Crainiciuc G, Cuartero MI, Casanova-Acebes M, Weiss LA, Huerga-Encabo H, Silvestre-Roig C, Rossaint J, Cossío I, Lechuga-Vieco AV, García-Prieto J, Gómez-Parrizas M, Quintana JA, Ballesteros I, Martin-Salamanca S, Aroca-Crevillen A, Chong SZ, Evrard M, Balabanian K, López J, Bidzhekov K, Bachelerie F, Abad-Santos F, Muñoz-Calleja C, Zarbock A, Soehnlein O, Weber C, Ng LG, Lopez-Rodriguez C, Sancho D, Moro MA, Ibáñez B, Hidalgo A (2019). A neutrophil timer coordinates immune defense and vascular protection. Immunity. 51:966-967. PMID 31747583. [A1, A6, A10, B5]
Ammar C, Gruber M, Csaba G, Zimmer R (2019b). MS-EmpiRe utilizes peptide-level noise distributions for ultrasensitive detection of differentially expressed proteins. Mol Cell Proteomics. 18:1880-92. PMID 31235637. [Z2]
Ammar C, Berchtold E, Csaba G, Schmidt A, Imhof A, Zimmer R (2019a). Multi-reference spectral library yiel almost complete coverage of heterogeneous LC-MS/MS data sets. J Proteome Res. 18:1553–66. PMID 30793903. [Z2]
Bartelt A, Leipsic J, Weber C (2019). The new age of radiomic risk profiling: perivascular fat at the heart of the matter. Eur Heart J. 40:3544-3546. PMID 31605139. [A1, A10, B10]
Bachmaier S, Santos YV, Kramer S, Githure GB, Klöckner T, Pepperl J, Baums C, Schenk R, Schwede F, Genieser HG, Dupuy JW, Forné I, Imhof A, Basquin J, Lorentzen E, Boshart M (2019). Nucleoside analogue activa-tors of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun. 10:1421. PMID 30926779. [Z2]
Beldman TJ, Malinova TS, Desclos E, Grootemaat AE, Misiak ALS, van der Velden S, van Roomen C, Beckers L, van Veen HA, Krawczyk PM, Hoebe RA, Sluimer JC, Neele AE, de Winther MPJ, van der Wel NN, Lutgens E, Mulder WJM, Huveneers S, Kluza E (2019). Nanoparticle-aided characterization of arterial endothelial architecture during atherosclerosis progression and metabolic therapy. ACS Nano. 13:13759-13774. PMID 31268670. [A5]
Berchtold E, Vetter M, Gündert M, Csaba G, Fathke C, Ulbrich SE, Thomssen C, Zimmer R, Kantelhardt EJ (2019). Comparison of six breast cancer classifiers using qPCR. Bioinformatics. 35:3412-3420. PMID 30759193. [Z2]
Bernhagen J (2019). Separating cytokine twins with a small molecule. J Biol Chem. 294:18532-18533. PMID 31811047. [A3]
Bianchini M*, Duchêne J*#, Santovito D, Schloss MJ, Evrard M, Winkels H, Aslani M, Mohanta SK, Horckmans M, Blanchet X, Lacy M, von Hundelshausen P, Atzler D, Habenicht A, Gerdes N, Pelisek J, Ng LG, Steffens S, Weber C#, Megens RTA (2019). PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function. Sci Immunol. 4:eaar3054. PMID 31227596. *shared first authors, #corresponding authors [A1, A2, A10, B9, C2, Z1]
Bollenbach A, Cordts K, Hanff E, Atzler D, Choe CU, Schwedhelm E, Tsikas D (2019). Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans. Anal Biochem. 577:59-66. PMID 31028716. [A5]
Bongiovanni D, Santamaria G, Klug M, Santovito D, Felicetta A, Hristov M, von Scheidt M, Aslani M, Cibella J, Weber C, Moretti A, Laugwitz KL, Peano C, Bernlochner I (2019). Transcriptome analysis of reticulated platelets reveals a prothrombotic profile. Thromb Haemost. 119:1795-1806. PMID 31473989. [A1, A10]
Bosch L, de Haan J, Seijkens T, van Tiel C, Brans M, Pasterkamp G, Lutgens E, de Jager S (2019). Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure. Int J Cardiol. 279:141-144. PMID 30612848. [A5]
Busygina K, Denzinger V, Bernlochner I, Weber C, Lorenz R, Siess W (2019). Btk inhibitors as first oral atherothrombosis-selective antiplatelet drugs? Thromb Haemost. 119:1212-1221. PMID 31087308. [A1, A10]
Cai R, Pan C, Ghasemigharagoz A, Todorov MI, Förstera B, Zhao S, Bhatia HS, Parra-Damas A, Mrowka L, Theodorou D, Rempfler M, Xavier ALR, Kress BT, Benakis C, Steinke H, Liebscher S, Bechmann I, Liesz A, Menze B, Kerschensteiner M, Nedergaard M, Ertürk A (2019). Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections. Nat Neurosci. 22:317-327. doi: 10.1038/s41593-018-0301-3. PMID 30598527. [C1]
Cassatella MA, Ostberg NK, Tamassia N, Soehnlein O (2019). Biological roles of neutrophil-derived granule proteins and cytokines. Trends Immunol. 40:648-664. PMID 31155315. [A6, B5]
Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdefessel L, Malin SG (2019). Germinal center-derived antibodies promote atherosclerosis plaque size and stability. Circulation. 139:2466-2482. PMID 30894016. [A5, B5]
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellidaes G, Simons M (2019). Endothelial TGF-beta signalling drives vascular inflammation and atherosclerosis. Nt Metab. 1:912-926. PMID 31572976. [A5]
Cimen I, Yildirim Z, Dogan AE, Yildirim AD, Tufanli O, Onat UI, Nguyen U, Watkins SM, Weber C, Erbay E (2019). Double bond configuration of palmitoleate is critical for atheroprotection. Mol Metab. 28:58-72. PMID 31422082. [A1, A10]
Clemmensen C, Finan B, Müller TD, DiMarchi RD, Tschöp MH, Hofmann SM (2019). Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases. Nat Rev Endocrinol. 15:90-104. PMID 30446744. [A4]
Cordts K, Grzybowski R, Lezius S, Luneburg N, Atzler D, Neu A, Hornig S, Boger RH, Gerloff C, Magnus T, Thomalla G, Schwedhelm E, Grant PJ, Choe CU (2019). Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA2DS2-VASc score in three cross-sectional studies. J Neurol Sci. 397:156-161. PMID 30640152. [A5]
Cremer S, Michalik KM, Fischer A, Pfisterer L, Jaé N, Winter C, Boon RA, Muhly-Reinholz M, John D, Uchida S, Weber C, Poller W, Günther S, Braun T, Li DY, Maegdefessel L, Matic Perisic L, Hedin U, Soehnlein O, Zeiher A, Dimmeler S (2019). Hematopoietic deficiency of the long non-coding RNA MALAT1 promotes atherosclerosis and plaque inflammation. Circulation. 139:1320-1334. PMID 30586743. [A1, A6, A10, B5]
De Juan A, Ince LM, Pick R, Chen CS, Molica F, Zuchtriegel G, Wang C, Zhang D, Druzd D, Hessenauer MET, Pelli G, Kolbe I, Oster H, Prophete C, Hergenhan SM, Albrecht U, Ripperger J, Montanez E, Reichel CA, Soehnlein O, Kwak BR, Frenette PS, Scheiermann C (2019). Artery-associated sympathetic innervation drives rhythmic vascular inflammation of arteries and veins. Circulation. 140:1100-1114. PMID 31401849. [A6, B5]
De Winther MPJ, Lutgens E (2019). The link between hematopoiesis and atherosclerosis. N Engl J Med. 380:1869-1871. PMID 31067380. [A5]
Denisov SS, Ippel JH, Heinzmann ACA, Koenen RR, Ortega-Gomez A, Soehnlein O, Hackeng TM, Dijkgraaf I (2019). Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2. J Biol Chem. 294:12370-12379. PMID 31235521. [A6, B5]
Dichgans M, Pulit SL, Rosand J (2019). Stroke genetics: discovery, biology, and clinical applications. Lancet Neu-rol. 18:587-599. PMID 30975520. [B3]
Döring Y, van der Vorst EPC, Duchene J, Jansen Y, Gencer S, Bidzhekov K, Atzler D, Santovito D, Rader DJ, Saleheen D, Weber C (2019). CXCL12 derived from endothelial cells promotes atherosclerosis to drive coronary artery disease. Circulation. 139:1338-1340. PMID 30865486. [A1, A5, A10, C2]
Eckardt V, Weber C, von Hundelshausen P (2019). Glycans and glycan-binding proteins in atherosclerosis. Thromb Haemost. 119:1265-1273. PMID 31266083. [A1, A2, A10]
Ferraro B, Leoni G, Hinkel R, Ormanns S, Paulin N, Ortega-Gomez A, Viola JR, de Jong R, Bongiovanni D, Bozoglu T, Maas SL, D'Amico M, Kessler T, Zeller T, Hristov M, Reutelingsperger C, Sager HB, Döring Y, Nahrendorf M, Kupatt C, Soehnlein O (2019). Pro-angiogenic macrophage phenotype to promote myocardial repair. J Am Coll Cardiol. 73:2990-3002. PMID 31196457. [A1, B2, B5, C1]
Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thoele J, Siuda D, Soehnlein O, Wittig I, Heidler J, Weigert A, Fleming I (2019). Myeloid-specific deletion of the AMPKalpha2 subunit alters monocyte protein expression and atherogenesis. Int J Mol Sci. 20. 20:3005. PMID 31248224. [A6, B5]
Gaertner F, Massberg S (2019). Patrolling the vascular borders: platelets in immunity to infection and cancer. Nat Rev Immunol. 19:747-760. PMID 31409920. [B6]
Gencer S, van der Vorst EPC, Aslani M, Weber C, Döring Y, Dûchene J (2019). Atypical chemokine receptors in cardiovascular disease. Thromb Haemost. 119:534-541. PMID 30716778. [A1, A10]
Georgakis MK, Malik R, Björkbacka H, Pana TA, Demissie S, Ayers C, Elhadad MA, Fornage M, Beiser AS, Benjamin EJ, Boekholdt SM, Engström G, Herder C, Hoogeveen RC, Koenig W, Melander O, Orho-Melander M, Schi-opu A, Söderholm M, Wareham N, Ballantyne CM, Peters A, Seshadri S, Myint PK, Nilsson J, de Lemos JA, Dichgans M (2019). Circulating monocyte chemoattractant protein-1 and risk of stroke: meta-analysis of population-based studies involving 17 180 individuals. Circ Res. 125:773-782. PMID 31476962. [B3]
Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CLM, Malik R, Dichgans M (2019). Genetically determined levels of circulating cytokines and risk of stroke. Circulation. 139:256-268. PMID 30586705. [A3, B3]
Gill D, Georgakis MK, Koskeridis F, Jiang L, Feng Q, Wei WQ, Theodoratou E, Elliott P, Denny JC, Malik R, Evan-gelou E, Dehghan A, Dichgans M#, Tzoulaki I# (2019). Use of genetic variants related to antihypertensive drugs to inform on efficacy and side effects. Circulation. 140:270-279. PMID 31234639. #shared corresponding authors [B3]
Goldmann L, Duan R, Kragh T, Wittmann G, Weber C, Lorenz R, von Hundelshausen P, Spannagl M, Siess W (2019). Oral bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (FcgammaRIIA): a new option in HIT? Blood Adv. 3:4021-4033. PMID 31809536. [A1, A2, A10]
González-Ramos S, Paz-García M, Rius C, Del Monte-Monge A, Rodríguez C, Fernández-García V, Andrés V, Martínez-González J, Lasunción MA, Martín-Sanz P, Soehnlein O, Boscá L (2019). Endothelial NOD1 directs myeloid cell recruitment in atherosclerosis through VCAM-1. FASEB J. 33:3912-3921. PMID 30496704. [A6, B5]
Guillamat-Prats R, Ramo M, Ring L, Rinne P, Lauer E, Lenglet S, Thomas A, Pagano S, Vuilleumier N, Cravatt BF, Weber C, Faussner A, Steffens S (2019b). Deficiency of monoacylglycerol lipase enhances IgM plasma levels and limits atherogenesis in a CB2-dependent manner. Thromb Haemost. 119:348-351. PMID 30609444. [A1, A10, B9]
Guillamat-Prats R, Rami M, Herzig S, Steffens S (2019a). Endocannabinoid signaling in atherosclerosis and related metabolic complications. Thromb Haemost. 119:567-575. PMID 30769363. [B9]
Hackler E 3rd, Lew J, Gore MO, Ayers CR, Atzler D, Khera A, Rohatgi A, Lewis A, Neeland I, Omland T, de Lemos JA (2019). Racial differences in cardiovascular biomarkers in the general population. J Am Heart Assoc. 8:e012729. PMID 31514563. [A5]
Hall KT*, Kessler T*, Buring JE, Passow D, Sesso HD, Zee RYL, Ridker PM, Chasman DI, Schunkert H (2019). Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin. Eur Heart J. 40:3385-3392. * equal contribution. PMID 31228190. [B2]
Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ (2019). The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Nat Metab. 1:98-110. PMID 31410392. [B5, B1]
Hollander MR, Jansen MF, Hopman L, Dolk E, van de Ven PM, Knaapen P, Horrevoets AJ, Lutgens E, van Royen N (2019). Stimulation of collateral vessel growth by inhibition of galectin 2 in mice using a single-domain llama-derived antibody. J Am Heart Assoc. 8:e012806. PMID 31594443. [A5]
Hu D, Yin C, Luo S, Habenicht AJR and Mohanta SK (2019). Vascular smooth muscle cells contribute to atherosclerosis immunity. Front Immunol. 10:1101. PMID 31164888. [C2]
Joppich M, Weber C, Zimmer R (2019). Using context-sensitive text mining to identify miRNAs in different stages of atherosclerosis. Thromb Haemost. 119:1247-1264. PMID 31378854. [A1, A10, Z2]
Kapurniotu A, Gokce O, Bernhagen J (2019). The multitasking potential of alarmins and atypical chemokines. Front Med. 6:3. PMID 30729111. [A3]
Kessler T, Wolf B, Eriksson N, Kofink D, Mahmoodi BK, Rai H, Tragante V, Åkerblom A, Becker RC, Bernlochner I, Bopp R, James S, Katus HA, Mayer K, Munz M, Nordio F, O'Donoghue ML, Sager HB, Sibbing D, Solakov L, Storey RF, Wobst J, Asselbergs FW, Byrne RA, Erdmann J, Koenig W, Laugwitz KL, Ten Berg JM, Wallentin L, Kastrati A, Schunkert H (2019). Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention. Cardiovasc Res. 115:1512-1518. PMID 30768153. [B2, C1]
Ketelhuth DFJ, Lutgens E, Back M, Binder CJ, Van den Bossche J, Daniel C, Dumitriu IE, Hoefer I, Libby P, O'Neill L, Weber C, Evans P (2019). Immunometabolism and atherosclerosis: perspectives and clinical significance- A position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology. Cardiovasc Res. 115:1385-1392. PMID 31228191. [A1, A5, A10]
Khyzha N, Khor M, diStefano PV, Wang L, Matic L, Hedin U, Wilson MD, Maegdefessel L, Fish JE (2019). Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA. Proc Natl Acad Sci U S A. 116:16410-16419. PMID 31350345. [B5]
Kiouptsi K, Jackel S, Pontarollo G, Grill A, Kuijpers MJE, Wilms E, Weber C, Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C, Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P, Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der Vorst EPC, Döring Y, Reinhardt C (2019). The microbiota promotes arterial thrombosis in low-density lipoprotein receptor-deficient mice. MBio. 10:e02298-19. PMID 31641089. [A1, A10]
Kornhuber KTI, Seidel H, Pujol C, Meierhofer C, Röschenthaler F, Pressler A, Stöckl A, Nagdyman N, Neidenbach RC, von Hundelshausen P, Halle M, Holdenrieder S, Ewert P, Kaemmerer H, Hauser M (2019). Hemostatic abnormalities in adult patients with Marfan syndrome. Cardiovasc. Diagn Ther. 9:S209-S220. PMID 31737529. [A2]
Lacy M, Atzler D, Liu R, de Winther M, Weber C, Lutgens E (2019). Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis. Pharmacol Ther. 193:50–62. PMID 30149100. [A1, A5, A10]
Lauterbach MA, Hanke JE, Serefidou M, Mangan MSJ, Kolbe CC, Hess T, Rothe M, Kaiser R, Hoss F, Gehlen J, Engels G, Kreutzenbeck M, Schmidt SV, Christ A, Imhof A, Hiller K, Latz E (2019). Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase. Immunity. 51:997-1011. PMID 31851905. [B7, Z2]
Libby P, Sidlow R, Lin AE, Gupta D, Jones LW, Moslehi J, Zeiher A, Jaiswal S, Schulz C, Blankstein R, Bolton KL, Steensma D, Levine RL, Ebert BL (2019). Clonal hematopoiesis: crossroads of aging, cardiovascular disease, and cancer: JACC review topic of the week. J Am Coll Cardiol. 74:567-577. PMID 31345432. [A7]
Liesz A (2019). The vascular side of Alzheimer's disease. Science. 365:223-224. PMID 31320524. [C1]
Lip GYH, Weber C (2019). Thrombosis and haemostasis wishes you a happy new year ahead! Thromb Haemost. 119:1–2. PMID 30597493. [A1, A10]
Lutgens E, Atzler D, Döring Y, Dûchene J, Steffens S, Weber C (2019). Immunotherapy for cardiovascular disease. Eur Heart J. 40:3937-3946. PMID 31121017. [A1, A5, A10, B9]
Lutgens E (2019). Epigenetic quenching of VSMC inflammation in CVD: H3K9me2 in control. Arterioscler Thromb Vasc Biol. 39:2199-2200. PMID 31644350. [A5]
Marx C, Novotny J, Salbeck D, Zellner KR, Nicolai L, Pekayvaz K, Kilani B, Stockhausen S, Bürgener N, Kupka D, Stocker TJ, Weckbach LT, Pircher J, Moser M, Joner M, Desmer W, Adriaenssens T, Neumann FJ, Gerschlick AH, Berg JMT, Lorenz M, Stark K (2019). Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps. Blood. 134:1859-1872. PMID 31481482. [A7]
Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, Allen A, Sum M, Obier N, Cottard F, Ulferts S, Preca BT, Hermann B, Maurer J, Greschik H, Hornung V, Einsle O, Perner S, Imhof A, Jung M, Schüle R (2019). KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Nat Struct Mol Biol. 26:361-371. PMID 31061526. [Z2]
Mühlhofer M, Berchtold E, Stratil CG, Csaba G, Kunold E, Bach NC, Sieber SA, Haslbeck M, Zimmer R, Buchner J (2019). The heat shock response in yeast maintains protein homeostasis by chaperoning and replenishing proteins. Cell Rep. 29:4593-4607.e8. PMID 31875563. [Z2]
Nagy M, van Geffen JP, Stegner D, Adams DJ, Braun A, de Witt SM, Elvers M, Geer MJ, Kuijpers MJE, Kunzelmann K, Mori J, Oury C, Pircher J, Pleines I, Poole AW, Senis YA, Verdoold R, Weber C, Nieswandt B, Heemskerk JWM, Baaten C (2019). Comparative analysis of microfluidics thrombus formation in multiple genetically modified mice: link to thrombosis and hemostasis. Front Cardiovasc Med. 6:99. PMID 31417909. [A1, A10]
Natarelli L, Weber C (2019). Next-generation therapeutic concepts for atherosclerosis: focus on cell specificity and noncoding RNAs. Thromb Haemost. 119:1199-1201. PMID 31378853. [A1, A10]
Neidhart M, Pajak A, Laskari K, Riksen NP, Joosten LAB, Netea MG, Lutgens E, Stroes ESG, Ciurea A, Distler O, Grigorian M, Karouzakis E (2019). Oligomeric S100A4 is associated with monocyte innate immune memory and bypass of tolerance to subsequent stimulation with lipopolysaccharides. Front Immunol. 10:791. PMID 31037071. [A5]
Nicolai L, Gaertner F, Massberg S (2019). Platelets in host defense: experimental and clinical insights. Trends Immunol. 40:922-938. PMID 31601520. [B6]
Nitz K, Lacy M, Atzler D (2019). Amino acids and their metabolism in atherosclerosis. Arterioscler Tromb Vasc Biol. 39:319-330. PMID 30650999. [A5]
Noels H, Weber C, Koenen RR (2019). Chemokines as therapeutic targets in cardiovascular disease. Arterioscler Thromb Vasc Biol. 39:583-592. PMID 30760014. [A1, A10]
Norheim F, Hasin-Brumshtein Y, Vergnes L, Chella Krishnan K, Pan C, Seldin MM, Hui ST, Mehrabian M, Zhou Z, Gupta S, Parks BW, Walch A, Reue K, Hofmann SM, Arnold AP, Lusis AJ (2019). Gene-by-sex interactions in mito-chondrial functions and cardio-metabolic traits. Cell Metab. 29:932-949.e4 PMID 30639359. [A4]
Ntalla I, Kanoni S, Zeng L, Giannakopoulou O, Danesh J, Watkins H, Samani NJ, Deloukas P, Schunkert H (2019). UK biobank cardiometabolic consortium CHD working group. Genetic risk score for coronary disease identifies predispositions to cardiovascular and noncardiovascular diseases. J Am Coll Cardiol. 73:2932-42. PMID 31196449. [B2]
Paloschi V, Winter H, Viola J, Soehnlein O, Maegdefessel L (2019). Mechanistic links between non-coding RNAs and myeloid cell inflammation in atherosclerosis. Thromb Haemost. 119:1205-1211. PMID 31035303. [A6, B5]
Pfeiler S, Thakur M, Grünauer P, Megens RTA, Joshi U, Coletti R, Samara V, Müller-Stoy G, Ishikawa-Ankerhold H, Stark K, Klingl A, Fröhlich T, Arnold GJ, Wörmann S, Bruns CJ, Algül H, Weber C, Massberg S, Engelmann B (2019). CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis. FASEB J. 33:1860-1872. PMID 30207797. [A1, A7, A10, B6]
Prestel M, Schicker CP, Webb T, Malik R, Lindner B, Ziesch N, Rex-Haffner M, Röh S, Viturawong T, Lehm M, Mokry M, den Ruijter H, Haitjema S, Asare Y, Söllner F, Ghaderi Najafabadi M, Aherrahrou R, Civelek M, Samani NJ, Mann M, Haffner C, Dichgans M (2019). The atherosclerosis risk variant rs2107595 mediates allele-specific transcriptional regulation of HDAC9 via E2F3 and Rb1. Stroke. 50:2651-2660. PMID 31500558. [B3]
Puhl SL, Steffens S (2019). Neutrophils in post-myocardial infarction inflammation: damage vs. resolution? Front Cardiovasc Med. 6:25. PMID 30937305. [B9]
Rasmuson J, Kenne E, Wahlgren M, Soehnlein O, Lindbom L (2019). Heparinoid sevuparin inhibits Streptococcus-induced vascular leak through neutralizing neutrophil-derived proteins. FASEB J. f 33:10443-10452. PMID 31216421. [A6, B5]
Reiche ME, den Toom M, Willemsen L, van Os B, Gijbels MJJ, Gerdes N, Aarts S, Lutgens E (2019). Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction. BMJ Open Diabetes Res Care. 7:e000829. PMID 31908798. [A5]
Sager HB, Husser O, Steffens S, Laugwitz KL, Schunkert H, Kastrati A, Ndrepepa G, Kessler T (2019). Time-of-day at symptom onset was not associated with infarct size and long-term prognosis in patients with ST-segment elevation myocardial infarction. J Transl Med. 17:180. PMID 31142323. [B9]
Schloss MJ, Horckmans M, Guillamat-Prats R, Hering D, Lauer E, Lenglet S, Weber C, Thomas A, Steffens S (2019). 2-arachidonoylglycerol mobilizes myeloid cells and worsens heart function after acute myocardial infarction. Cardiovasc Res. 115:602-613. PMID 30295758. [A1, A10, B9]
Seijkens TTP, Poels K, Meiler S, van Tiel CM, Kusters PJH, Reiche M, Atzler D, Winkels H, Tjwa M, Poelmann H, Slütter B, Kuiper J, Gijbels M, Kuivenhoven JA, Matic LP, Paulsson-Berne G, Hedin U, Hansson GK, Nicolaes GAF, Daemen MJAP, Weber C, Gerdes N, de Winther MPJ, Lutgens E (2019). Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death. Eur Heart J. 40:372-382. PMID 30452556. [A1, A5, A10]
Seitz S, Kwon Y, Hartleben G, Jülg J, Sekar R, Krahmer N, Najafi B, Loft A, Gancheva S, Stemmer K, Feuchtinger A, Hrabe de Angelis M, Müller TD, Mann M, Blüher M, Roden M, Berriel Diaz M, Behrends C, Gilleron J, Herzig S, Zeigerer A (2019). Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. Nat Metab. 1:1009-1026. PMID 32694843. [B9]
Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O (2019). Externalized histone H4 orchestrates chronic inflam-mation by inducing lytic cell death. Nature. 569:236-240. PMID 31043745. [A1, A5, A6, A10, B5, Z1]
Silvestre-Roig C*, Fridlender ZG*, Glogauer M, Scapini P (2019). Neutrophil diversity in health and disease. Trends Immunol. 40:565-583. PMID 31160207. *shared first authors [A6]
Sinitski D, Kontos C, Krammer C, Asare Y, Kapurniotu A*, Bernhagen J* (2019). Macrophage migration inhibitory factor (MIF)-ba-sed therapeutic concepts in atherosclerosis and inflammation. Thromb Haemost. 119:553-566. PMID 30716779. [A3, B3]
Soehnlein O (2019). Neutrophil research, quo vadis? Trends Immunol. 40:561-564. PMID 31133465. [A6, B5]
Steffens S, Weber C (2019). Immunotherapy for atherosclerosis-novel concepts. Thromb Haemost. 119:515-516. PMID 30887489. [A1, A10, B9]
Stremmel C, Stark K, Schulz C (2019). Heterogeneity of macrophages in atherosclerosis. Thromb Haemost. 119:1237-1246. PMID 31242520. Review. [A7]
Thiem K, Hoeke G, van den Berg S, Hijmans A, Jacobs CWM, Zhou E, Mol IM, Mouktaroudi M, Bussink J, Kanneganti TD, Lutgens E, Stienstra R, Tack CJ, Netea MG, Rensen PCN, Berbee JFP, van Diepen JA (2019). Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice. Sci Rep. 9:4337. PMID 30867470. [A5]
Tunon J, Badimon L, Bochaton-Piallat ML, Cariou B, Daemen MJ, Egido J, Evans PC, Hoefer IE, Ketelhuth DFJ, Lutgens E, Matter CM, Monaco C, Steffens S, Stroes E, Vindis C, Weber C, Back M; ESC working group on atherosclerosis and vascular biology (2019). Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology. Cardiovasc Res. 115:10–9. PMID 30534957. [A1, A5, A10, B9]
Van Avondt K, Maegdefessel L, Soehnlein O (2019). Therapeutic targeting of neutrophil extracellular traps in atherogenic inflammation. Thromb Haemost. 119:542-552. PMID 30731493. [A6, B5]
van der Vorst EPC, Mandl M, Müller M, Neideck C, Jansen Y, Hristov M, Gencer S, Peters LJF, Meiler S, Feld M, Geiselhöringer AL, de Jong RJ, Ohnmacht C, Noels H, Soehnlein O, Drechsler M, Weber C, Döring Y (2019). Hematopoietic ChemR23 (Chemerin Receptor 23) fuels atherosclerosis by sustaining an M1 macrophage-pheno-type and guidance of plasmacytoid dendritic cells to murine lesions. Arterioscler Thromb Vasc Biol. 39:685-693. PMID 30786742. [A1, A10, B5, C2]
Van der Vorst EPC, Peters LJF, Müller M, Gencer S, Yan Y, Weber C, Döring Y (2019a). G-Protein coupled receptor targeting on myeloid cells in atherosclerosis. Front Pharmacol. 10:531. PMID 31191301. [A1, A10]
Varasteh Z, Mohanta SK, Robu S, Braeuer M, Li Y, Omidvari N, Topping G, Sun T, Nekolla SG, Richter A, Weber C, Habenicht A, Haberkorn UA, Weber WA (2019). Molecular imaging of fibroblast activity after myocardial infarction using a (68)Ga-labelled fibroblast activation protein inhibitor FAPI-04. J Nucl Med. 60:1743-1749. PMID 31405922. [A1, A10]
Vila-Caballer M, Gonzalez-Granado JM, Zorita V, Abu Nabah YN, Silvestre-Roig C, Del Monte-Monge A, Molina-Sanchez P, Ait-Oufella H, Andres-Manzano MJ, Sanz MJ, Weber C, Kremer L, Gutierrez J, Mallat Z, Andres V (2019). Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. J Mol Cell Cardiol. 132:154-163. PMID 31121182. [A1, A6, A10]
Weber C, Lip GYH (2019).Thrombosis and Haemostasis 2018 Editor's Choice Papers. Thromb Haemost. 119:183-186. PMID 30597513. [A1, A10]
Wichapong K, Poelman H, Ercig B, Hrdinova J, Liu X, Lutgens E, Nicolaes GA (2019). Rational modulator design by exploitation of protein-protein complex structures. Future Med Chem. 11:1015-1033. PMID 31141413. [A5]
Willemsen L, Neele AE, van der Velden S, Prange KHM, den Toom M, van Roomen C, Reiche ME, Griffith GR, Gijbels MJJ, Lutgens E, de Winther MPJ (2019). Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss. BMJ Open Diabetes Res Care. 7:e000751. PMID 31798899. [A5]
Winkler MJ, Müller P, Sharifi AM, Wobst J, Winter H, Mokry M, Ma L, van der Laan SW, Pang S, Miritsch B, Hinter-dobler J, Werner J, Stiller B, Güldener U, Webb TR, Asselbergs FW, Björkegren JLM, Maegdefessel L, Schunkert H, Sager HB, Kessler T (2019). Functional investigation of the coronary artery disease gene SVEP1. Basic Res Cardiol. 115:67. PMID 33185739. [B2, B5, C1]
Worthmann A, Schlein C, Berbée JFP, Rensen PCN, Heeren J, Bartelt A (2019). Effects of pharmacological ther-mogenic adipocyte activation on metabolism and atherosclerotic plaque regression. Nutrients. 11:463. PMID 30813320. [B10]
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li C, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Azrberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR (2019). ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med. 25:496-506. PMID 30692699. [A1, A10, B9, C2, Z1]